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Original Studies |
and ß in the Human Reproductive Organs
Oncology and Molecular Endocrinology Research Center, Laval University Hospital (CHUL), and Laval University, Québec, Canada G1V 4G2
Address all correspondence and requests for reprints to: Dr. Georges Pelletier, Oncology and Molecular Endocrinology Research Center, Laval University Hospital (CHUL), 2705 Laurier boulevard, Québec, Québec, Canada G1V 4G2. E-mail: georges.pelletier{at}crchul.ulaval.ca
To better define the role of estrogens in reproductive functions, we
have proceeded to the immunocytochemical localization of the estrogen
receptor (ER) subtypes, ER
and the recently discovered ERß, in
human reproductive tissues. In the ovary, ERß immunoreactivity was
found in nuclei of granulosa cells of growing follicles at all stages
from primary to mature follicles, interstitial gland, and germinal
epithelium cells. Nuclear staining for ER occurred in thecal,
interstitial gland, and germinal epithelium cells. In the uterus,
strong ER immunoreactivity was detected in nuclei of epithelial,
stromal, and muscle cells. Similar localization was obtained for ERß,
although the staining was much weaker. In the vagina, only ER could
be detected; a nuclear reaction was observed in deep layers of the
stratified epithelium as well as in stromal and muscle cells. In the
mammary gland, both ER subtypes were observed in epithelial and stromal
cells. In the testis, ERß was detected in nuclei of Sertoli and
Leydig cells, whereas ER immunoreactivity was only observed in
Leydig cells, with no tubular labeling. In the efferent ducts, only
ERß could be detected, whereas neither ERß nor ER could be found
in the epididymis. In the prostate, ERß nuclear immunolabeling was
observed in both basal and secretory cells in alveoli as well as in
stromal cells, whereas ER could not be detected. The present results
demonstrate that there is a cell-specific localization for each of the
ER subtypes in the majority of the reproductive organs studied.
Moreover, they contribute to establish the exact sites of action of
estrogens in male and female human reproductive systems.
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