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The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 10 3840-3846
Copyright © 2000 by The Endocrine Society

Original Studies

Estrogen Receptor ß (ERß) Messenger Ribonucleic Acid (mRNA) Expression within the Human Forebrain: Distinct Distribution Pattern to ER{alpha} mRNA1

Marie K. Österlund, Jan-Åke Gustafsson, Eva Keller and Yasmin L. Hurd

Department of Clinical Neuroscience, Section of Psychiatry, Karolinska Institute, Karolinska Hospital (M.K.Ö., Y.L.H.), S-171 76 Stockholm, Sweden; Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute (J.-Å. G.), Novum, S-141 86 Huddinge, Sweden; and Department of Forensic Medicine, Semmelweis University of Medicine (E.K.), 1091 Budapest, Ulloi 93, Hungary

Address all correspondence and requests for reprints to: Dr. Yasmin L. Hurd, Department of Clinical Neuroscience, Section of psychiatry, Karolinska Institute, Karolinska Hospital, S-171 76 Stockholm, Sweden. E-mail: yasmin.hurd{at}neuro.ks.se

Estrogen has been shown to influence several brain functions as well as the expression of neuropsychiatric diseases. To date, two estrogen receptor (ER) subtypes have been identified, ER{alpha} and ERß. ER{alpha} messenger ribonucleic acid (mRNA) distribution in the human forebrain was recently characterized, and the highest expression was found in restricted areas of the amygdala and hypothalamus. However, no information exists with regard to ERß mRNA distribution in the human brain. To this end, the anatomical distribution pattern of ERß mRNA expression in the human forebrain was investigated in the present study. Overall, the ERß mRNA hybridization signal was relatively low, but the most abundant ERß mRNA areas were the hippocampal formation (primarily the subiculum), claustrum, and cerebral cortex; expression was also present in the subthalamic nucleus and thalamus (ventral lateral nucleus). In contrast to ER{alpha} (studied on adjacent brain sections), ERß mRNA expression was low in the hypothalamus and amygdala. Based on the revealed anatomical distribution of the human ERß gene expression, a putative role for ERß in the modulation of cognition, memory, and motor functions is suggested.




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