help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Papotti, M.
Right arrow Articles by Muccioli, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Papotti, M.
Right arrow Articles by Muccioli, G.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Compound via MeSH
*Substance via MeSH
The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 10 3803-3807
Copyright © 2000 by The Endocrine Society

Original Studies

Growth Hormone Secretagogue Binding Sites in Peripheral Human Tissues1

Mauro Papotti, Corrado Ghè, Paola Cassoni, Filomena Catapano, Romano Deghenghi, Ezio Ghigo and Giampiero Muccioli

Departments of Biomedical Sciences and Oncology (M.P., P.C.), Anatomy, Pharmacology and Forensic Medicine (C.G., F.C., G.M.) and Internal Medicine (E.G.), University of Turin, Turin, 10125 Italy; and Europeptides (R.D.), Argenteuil 95108, France

Address correspondence and requests for reprints to: G. Muccioli, Ph.D., Division of Pharmacology, Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Via P. Giuria 13, 10125 Turin, Italy. E-mail: muccioli{at}medfarm.unito.it

The family of GH secretagogues (GHS) includes peptidyl (hexarelin) and nonpeptidyl (MK 0677) molecules possessing specific receptors in the brain, pituitary, and thyroid. GHS receptor subtypes have also been identified in the heart; and a gastric-derived peptide, named ghrelin, has recently been proposed as a natural ligand. Our aim was to investigate the presence of GHS receptors in a wide range of human tissues, by radioreceptor assay with [125I]Tyr-Ala-hexarelin. GHS receptors were detected mainly in the myocardium, but they were also present (in order of decreasing binding activity) in adrenal, gonads, arteries, lung, liver, skeletal muscle, kidney, pituitary, thyroid, adipose tissue, veins, uterus, skin, and lymphnode. In contrast, negligible binding was found in parathyroid, pancreas, placenta, mammary gland, prostate, salivary gland, stomach, colon, and spleen. Hexarelin, MK 0677, and human ghrelin completely displaced the radioligand from binding sites of endocrine tissues, but MK 0677 and ghrelin were less potent than hexarelin. In nonendocrine tissues, both MK 0677 and ghrelin were inactive in displacement of [125I]Tyr-Ala-hexarelin, whereas hexarelin was as active as a displacing agent in endocrine tissues. This study provides the first detailed analysis of the tissue localization of GHS receptors and suggests that a still unknown receptor subtype, specific for peptidyl GHS, may exist in the heart and in other tissues.




This article has been cited by other articles:


Home page
 DiabetesHome page
E. T. Vestergaard, L. C. Gormsen, N. Jessen, S. Lund, T. K. Hansen, N. Moller, and J. O. L. Jorgensen
Ghrelin Infusion in Humans Induces Acute Insulin Resistance and Lipolysis Independent of Growth Hormone Signaling
Diabetes, December 1, 2008; 57(12): 3205 - 3210.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I. Johansson, S. Destefanis, N. D. Aberg, M. A. I. Aberg, K. Blomgren, C. Zhu, C. Ghe, R. Granata, E. Ghigo, G. Muccioli, et al.
Proliferative and Protective Effects of Growth Hormone Secretagogues on Adult Rat Hippocampal Progenitor Cells
Endocrinology, May 1, 2008; 149(5): 2191 - 2199.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. T. Vestergaard, C. B. Djurhuus, J. Gjedsted, S. Nielsen, N. Moller, J. J. Holst, J. O. L. Jorgensen, and O. Schmitz
Acute Effects of Ghrelin Administration on Glucose and Lipid Metabolism
J. Clin. Endocrinol. Metab., February 1, 2008; 93(2): 438 - 444.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Granado, A. I. Martin, M. Lopez-Menduina, A. Lopez-Calderon, and M. A. Villanua
GH-releasing peptide-2 administration prevents liver inflammatory response in endotoxemia
Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E131 - E141.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. Xu, J. Pang, H. Yin, M. Li, W. Hao, C. Chen, and J.-M. Cao
Hexarelin suppresses cardiac fibroblast proliferation and collagen synthesis in rat
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2952 - H2958.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. T. Vestergaard, N. H. Andersen, T. K. Hansen, L. M. Rasmussen, N. Moller, K. E. Sorensen, E. Sloth, and J. O. L. Jorgensen
Cardiovascular effects of intravenous ghrelin infusion in healthy young men
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3020 - H3026.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Wu, W. Dong, M. Zhou, F. Zhang, C. P. Marini, T. S. Ravikumar, and P. Wang
Ghrelin Attenuates Sepsis-induced Acute Lung Injury and Mortality in Rats
Am. J. Respir. Crit. Care Med., October 15, 2007; 176(8): 805 - 813.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Tropea, F. Tiberi, F. Minici, M. Orlando, M. F. Gangale, F. Romani, F. Miceli, S. Catino, S. Mancuso, M. Sanguinetti, et al.
Ghrelin Affects the Release of Luteolytic and Luteotropic Factors in Human Luteal Cells
J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3239 - 3245.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. T. Vestergaard, T. K. Hansen, L. C. Gormsen, P. Jakobsen, N. Moller, J. S. Christiansen, and J. O. L. Jorgensen
Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1829 - E1836.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. Baessler, M. Fischer, B. Mayer, M. Koehler, S. Wiedmann, K. Stark, A. Doering, J. Erdmann, G. Riegger, H. Schunkert, et al.
Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease
Hum. Mol. Genet., April 15, 2007; 16(8): 887 - 899.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M. C Garcia, M. Lopez, C. V Alvarez, F. Casanueva, M. Tena-Sempere, and C. Dieguez
Role of ghrelin in reproduction
Reproduction, March 1, 2007; 133(3): 531 - 540.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
T. Ishikawa, H. Fujioka, T. Ishimura, A. Takenaka, and M. Fujisawa
Ghrelin Expression in Human Testis and Serum Testosterone Level
J Androl, March 1, 2007; 28(2): 320 - 324.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. Filigheddu, V. F. Gnocchi, M. Coscia, M. Cappelli, P. E. Porporato, R. Taulli, S. Traini, G. Baldanzi, F. Chianale, S. Cutrupi, et al.
Ghrelin and Des-Acyl Ghrelin Promote Differentiation and Fusion of C2C12 Skeletal Muscle Cells
Mol. Biol. Cell, March 1, 2007; 18(3): 986 - 994.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Baessler, A. E. Kwitek, M. Fischer, M. Koehler, W. Reinhard, J. Erdmann, G. Riegger, A. Doering, H. Schunkert, and C. Hengstenberg
Association of the Ghrelin Receptor Gene Region With Left Ventricular Hypertrophy in the General Population: Results of the MONICA/KORA Augsburg Echocardiographic Substudy
Hypertension, May 1, 2006; 47(5): 920 - 927.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
P J D Delhanty, B C J van der Eerden, M van der Velde, C Gauna, H A P Pols, H Jahr, H Chiba, A J van der Lely, and J P T M van Leeuwen
Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a
J. Endocrinol., January 1, 2006; 188(1): 37 - 47.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
P L Jeffery, R E Murray, A H Yeh, J F McNamara, R P Duncan, G D Francis, A C Herington, and L K Chopin
Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell lines
Endocr. Relat. Cancer, December 1, 2005; 12(4): 839 - 850.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. H. Yeh, P. L. Jeffery, R. P. Duncan, A. C. Herington, and L. K. Chopin
Ghrelin and a Novel Preproghrelin Isoform Are Highly Expressed in Prostate Cancer and Ghrelin Activates Mitogen-Activated Protein Kinase in Prostate Cancer
Clin. Cancer Res., December 1, 2005; 11(23): 8295 - 8303.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Granado, T. Priego, A. I. Martin, M{a} A. Villanua, and A. Lopez-Calderon
Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle
Am J Physiol Endocrinol Metab, December 1, 2005; 289(6): E1007 - E1014.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Wu, W. Dong, M. Zhou, X. Cui, H. Hank Simms, and P. Wang
Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1
Cardiovasc Res, November 1, 2005; 68(2): 318 - 326.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
R. Giordano, A. Picu, U. Pagotto, R. De Iasio, L. Bonelli, F. Prodam, F. Broglio, L. Marafetti, R. Pasquali, M. Maccario, et al.
The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing's disease
Eur. J. Endocrinol., October 1, 2005; 153(4): 535 - 543.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X.-B. Xu, J.-J. Pang, J.-M. Cao, C. Ni, R.-K. Xu, X.-Z. Peng, X.-X. Yu, S. Guo, M.-C. Chen, and C. Chen
GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure
Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1643 - H1651.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
T Kitazawa, B De Smet, K Verbeke, I Depoortere, and T L Peeters
Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro
Gut, August 1, 2005; 54(8): 1078 - 1084.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Groschl, H. G. Topf, J. Bohlender, J. Zenk, S. Klussmann, J. Dotsch, W. Rascher, and M. Rauh
Identification of Ghrelin in Human Saliva: Production by the Salivary Glands and Potential Role in Proliferation of Oral Keratinocytes
Clin. Chem., June 1, 2005; 51(6): 997 - 1006.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. G. Smith
Development of Growth Hormone Secretagogues
Endocr. Rev., May 1, 2005; 26(3): 346 - 360.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. E. Caminos, O. Gualillo, F. Lago, M. Otero, M. Blanco, R. Gallego, T. Garcia-Caballero, M. B. Goldring, F. F. Casanueva, J. J. Gomez-Reino, et al.
The Endogenous Growth Hormone Secretagogue (Ghrelin) Is Synthesized and Secreted by Chondrocytes
Endocrinology, March 1, 2005; 146(3): 1285 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Gauna, P. J. D. Delhanty, L. J. Hofland, J. A. M. J. L. Janssen, F. Broglio, R. J. M. Ross, E. Ghigo, and A. J. van der Lely
Ghrelin Stimulates, Whereas Des-Octanoyl Ghrelin Inhibits, Glucose Output by Primary Hepatocytes
J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 1055 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Henriques-Coelho, J. Correia-Pinto, R. Roncon-Albuquerque Jr, M. J. Baptista, A. P. Lourenco, S. M. Oliveira, A. Brandao-Nogueira, A. Teles, J. M. Fortunato, and A. F. Leite-Moreira
Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension
Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2885 - H2890.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
W. Zhang, T. R. Lin, Y. Hu, Y. Fan, L. Zhao, E. L. Stuenkel, and M. W. Mulholland
Ghrelin stimulates neurogenesis in the dorsal motor nucleus of the vagus
J. Physiol., September 15, 2004; 559(3): 729 - 737.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. S. Kim, C. Y. Yoon, P. G. Jang, Y. J. Park, C. S. Shin, H. S. Park, J. W. Ryu, Y. K. Pak, J. Y. Park, K. U. Lee, et al.
The Mitogenic and Antiapoptotic Actions of Ghrelin in 3T3-L1 Adipocytes
Mol. Endocrinol., September 1, 2004; 18(9): 2291 - 2301.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Wu, M. Zhou, X. Cui, H. H. Simms, and P. Wang
Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis
Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1296 - H1302.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. J. van der Lely, M. Tschop, M. L. Heiman, and E. Ghigo
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
Endocr. Rev., June 1, 2004; 25(3): 426 - 457.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
W. G. Li, D. Gavrila, X. Liu, L. Wang, S. Gunnlaugsson, L. L. Stoll, M. L. McCormick, C. D. Sigmund, C. Tang, and N. L. Weintraub
Ghrelin Inhibits Proinflammatory Responses and Nuclear Factor-{kappa}B Activation in Human Endothelial Cells
Circulation, May 11, 2004; 109(18): 2221 - 2226.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Sun, P. Wang, H. Zheng, and R. G. Smith
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
PNAS, March 30, 2004; 101(13): 4679 - 4684.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. INUI, A. ASAKAWA, C. Y. BOWERS, G. MANTOVANI, A. LAVIANO, M. M. MEGUID, and M. FUJIMIYA
Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
FASEB J, March 1, 2004; 18(3): 439 - 456.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. P. Camina, M. C. Carreira, S. El Messari, C. Llorens-Cortes, R. G. Smith, and F. F. Casanueva
Desensitization and Endocytosis Mechanisms of Ghrelin-Activated Growth Hormone Secretagogue Receptor 1a
Endocrinology, February 1, 2004; 145(2): 930 - 940.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Gaytan, M. L. Barreiro, J. E. Caminos, L. K. Chopin, A. C. Herington, C. Morales, L. Pinilla, R. Paniagua, M. Nistal, F. F. Casanueva, et al.
Expression of Ghrelin and Its Functional Receptor, the Type 1a Growth Hormone Secretagogue Receptor, in Normal Human Testis and Testicular Tumors
J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 400 - 409.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. M. Thompson, D. A. S. Gill, R. Davies, N. Loveridge, P. A. Houston, I. C. A. F. Robinson, and T. Wells
Ghrelin and Des-Octanoyl Ghrelin Promote Adipogenesis Directly in Vivo by a Mechanism Independent of the Type 1a Growth Hormone Secretagogue Receptor
Endocrinology, January 1, 2004; 145(1): 234 - 242.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Tassone, F. Broglio, S. Destefanis, S. Rovere, A. Benso, C. Gottero, F. Prodam, R. Rossetto, C. Gauna, A. J. van der Lely, et al.
Neuroendocrine and Metabolic Effects of Acute Ghrelin Administration in Human Obesity
J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5478 - 5483.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
X.-B. Xu, J.-M. Cao, J.-J. Pang, R.-K. Xu, C. Ni, W.-L. Zhu, K. Asotra, M.-C. Chen, and C. Chen
The Positive Inotropic and Calcium-Mobilizing Effects of Growth Hormone-Releasing Peptides on Rat Heart
Endocrinology, November 1, 2003; 144(11): 5050 - 5057.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
U. Pagotto, A. Gambineri, C. Pelusi, S. Genghini, M. Cacciari, B. Otto, T. Castaneda, M. Tschop, and R. Pasquali
Testosterone Replacement Therapy Restores Normal Ghrelin in Hypogonadal Men
J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4139 - 4143.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Broglio, C. Gottero, A. Benso, F. Prodam, S. Destefanis, C. Gauna, M. Maccario, R. Deghenghi, A. J. van der Lely, and E. Ghigo
Effects of Ghrelin on the Insulin and Glycemic Responses to Glucose, Arginine, or Free Fatty Acids Load in Humans
J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4268 - 4272.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
I.A. Harsch, P.C. Konturek, C. Koebnick, P.P. Kuehnlein, F.S. Fuchs, S. Pour Schahin, G.H. Wiest, E.G. Hahn, T. Lohmann, and J.H. Ficker
Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment
Eur. Respir. J., August 1, 2003; 22(2): 251 - 257.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
Y.-T. Shen, J. J. Lynch, R. J. Hargreaves, and R. J. Gould
A Growth Hormone Secretagogue Prevents Ischemic-Induced Mortality Independently of the Growth Hormone Pathway in Dogs with Chronic Dilated Cardiomyopathy
J. Pharmacol. Exp. Ther., August 1, 2003; 306(2): 815 - 820.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Kawamura, N. Sato, J. Fukuda, H. Kodama, J. Kumagai, H. Tanikawa, A. Nakamura, Y. Honda, T. Sato, and T. Tanaka
Ghrelin Inhibits the Development of Mouse Preimplantation Embryos in Vitro
Endocrinology, June 1, 2003; 144(6): 2623 - 2633.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Tanaka, H. Minoura, T. Isobe, H. Yonaha, H. Kawato, D. F. Wang, T. Yoshida, M. Kojima, K. Kangawa, and N. Toyoda
Ghrelin Is Involved in the Decidualization of Human Endometrial Stromal Cells
J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 2335 - 2340.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Torsello, E. Bresciani, G. Rossoni, R. Avallone, G. Tulipano, D. Cocchi, I. Bulgarelli, R. Deghenghi, F. Berti, and V. Locatelli
Ghrelin Plays a Minor Role in the Physiological Control of Cardiac Function in the Rat
Endocrinology, May 1, 2003; 144(5): 1787 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
I. Depoortere, T. Thijs, L. Thielemans, P. Robberecht, and T. L. Peeters
Interaction of the Growth Hormone-Releasing Peptides Ghrelin and Growth Hormone-Releasing Peptide-6 with the Motilin Receptor in the Rabbit Gastric Antrum
J. Pharmacol. Exp. Ther., May 1, 2003; 305(2): 660 - 667.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M.L. Barreiro, J.S. Suominen, F. Gaytan, L. Pinilla, L.K. Chopin, F.F. Casanueva, C. Dieguez, E. Aguilar, J. Toppari, and M. Tena-Sempere
Developmental, Stage-Specific, and Hormonally Regulated Expression of Growth Hormone Secretagogue Receptor Messenger RNA in Rat Testis
Biol Reprod, May 1, 2003; 68(5): 1631 - 1640.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Arosio, C. L. Ronchi, C. Gebbia, V. Cappiello, P. Beck-Peccoz, and M. Peracchi
Stimulatory Effects of Ghrelin on Circulating Somatostatin and Pancreatic Polypeptide Levels
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 701 - 704.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Gaytan, M. L. Barreiro, L. K. Chopin, A. C. Herington, C. Morales, L. Pinilla, F. F. Casanueva, E. Aguilar, C. Dieguez, and M. Tena-Sempere
Immunolocalization of Ghrelin and Its Functional Receptor, the Type 1a Growth Hormone Secretagogue Receptor, in the Cyclic Human Ovary
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 879 - 887.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. M. Seoane, M. Lopez, S. Tovar, F. F. Casanueva, R. Senaris, and C. Dieguez
Agouti-Related Peptide, Neuropeptide Y, and Somatostatin-Producing Neurons Are Targets for Ghrelin Actions in the Rat Hypothalamus
Endocrinology, February 1, 2003; 144(2): 544 - 551.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Volante, E. Allia, E. Fulcheri, P. Cassoni, E. Ghigo, G. Muccioli, and M. Papotti
Ghrelin in Fetal Thyroid and Follicular Tumors and Cell Lines: Expression and Effects on Tumor Growth
Am. J. Pathol., February 1, 2003; 162(2): 645 - 654.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. Sibilia, G. Rindi, F. Pagani, D. Rapetti, V. Locatelli, A. Torsello, N. Campanini, R. Deghenghi, and C. Netti
Ghrelin Protects Against Ethanol-Induced Gastric Ulcers in Rats: Studies on the Mechanisms of Action
Endocrinology, January 1, 2003; 144(1): 353 - 359.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
G. Baldanzi, N. Filigheddu, S. Cutrupi, F. Catapano, S. Bonissoni, A. Fubini, D. Malan, G. Baj, R. Granata, F. Broglio, et al.
Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
J. Cell Biol., December 23, 2002; 159(6): 1029 - 1037.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
U. Pagotto, A. Gambineri, V. Vicennati, M. L. Heiman, M. Tschop, and R. Pasquali
Plasma Ghrelin, Obesity, and the Polycystic Ovary Syndrome: Correlation with Insulin Resistance and Androgen Levels
J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5625 - 5629.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M.L. Barreiro, F. Gaytan, J.E. Caminos, L. Pinilla, F.F. Casanueva, E. Aguilar, C. Dieguez, and M. Tena-Sempere
Cellular Location and Hormonal Regulation of Ghrelin Expression in Rat Testis
Biol Reprod, December 1, 2002; 67(6): 1768 - 1776.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Tamura, J. Kamegai, T. Shimizu, S. Ishii, H. Sugihara, and S. Oikawa
Ghrelin Stimulates GH But Not Food Intake in Arcuate Nucleus Ablated Rats
Endocrinology, September 1, 2002; 143(9): 3268 - 3275.
[Abstract] [Full Text] [PDF]