| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Original Studies |
INSERM U-449, Faculté de Médecine René T.H. Laennec (A.M., C.T., J.O., A.M.M.), 69372 Lyon; and Faculté de Pharmacie, Unité Mixte de Recherche 9921, (F.R.), 34060 Montpellier, France
Address all correspondence and requests for reprints to: Dr. A Mayer, INSERM U-449, Faculté de Médecine René T.H. Laennec, rue Guillaume Paradin, 69372 Lyon Cedex 08. France. E-mail: madec{at}laennec.univ-lyon1.fr
Antigenic proliferative responses of peripheral blood mononuclear cells
(PBMC) to insulin were studied in 44 type 1 new-onset diabetic
subjects. Of them, 14 (32%) had a stimulation index (
3) above the
mean + 3 SD of 39 healthy controls and of 7 of 15 (47%)
diabetic patients of long duration (P = 0.001).
Responses to insulin were not dictated by specific major
histocompatibility complex class II association and were not observed
in normal subjects with diabetes-associated human leukocyte
antigen-DR/DQ alleles. Whereas no relation of PBMC reactivity with
insulin autoantibodies was found, there was a positive correlation with
the presence of at least one of the four autoantibodies tested and with
IA-2 antibody. An interesting finding was that the proportion of
patients with subsequent low insulin requirement, up to 24 months, was
significantly higher in patients who showed PBMC reactivity to insulin
(8 of 8) than in those who did not (10 of 24, 42%;
P = 0.004). The former had a higher mean
stimulation index than the latter (3.3 ± 2.6 vs.
1.5 ± 0.6; P = 0.006). Furthermore,
interleukin-4 (IL-4) production was lower in type 1 diabetic patients
who proliferated to insulin than in those who did not (23 ± 15
vs. 64 ± 47 pg/mL; P = 0.04),
but interferon-
, IL-2, and IL-10 productions were similar. In
conclusion, these results suggest that proliferation to insulin may
reflect the presence of an higher residual ß-cell mass.
This article has been cited by other articles:
 |
|
 |
|
  S. E. Fineberg, T. T. Kawabata, D. Finco-Kent, R. J. Fountaine, G. L. Finch, and A. S. Krasner Immunological Responses to Exogenous Insulin Endocr. Rev., October 1, 2007; 28(6): 625 - 652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Mayer, N Fabien, M C Gutowski, V Dubois, L Gebuhrer, J Bienvenu, J Orgiazzi, and A M Madec Contrasting cellular and humoral autoimmunity associated with latent autoimmune diabetes in adults Eur. J. Endocrinol., July 1, 2007; 157(1): 53 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Skarsvik, J. Puranen, J. Honkanen, M. Roivainen, J. Ilonen, H. Holmberg, J. Ludvigsson, and O. Vaarala Decreased in vitro type 1 immune response against coxsackie virus b4 in children with type 1 diabetes. Diabetes, April 1, 2006; 55(4): 996 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lohmann, S. Laue, U. Nietzschmann, T.M. Kapellen, I. Lehmann, S. Schroeder, R. Paschke, and W. Kiess Reduced Expression of Th1-Associated Chemokine Receptors on Peripheral Blood Lymphocytes at Diagnosis of Type 1 Diabetes Diabetes, August 1, 2002; 51(8): 2474 - 2480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Borg, A. Gottsater, P. Fernlund, and G. Sundkvist A 12-Year Prospective Study of the Relationship Between Islet Antibodies and {beta}-Cell Function At and After the Diagnosis in Patients With Adult-Onset Diabetes Diabetes, June 1, 2002; 51(6): 1754 - 1762. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
