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Measurements of Insulin-Mediated Glucose Disposal Are Stable Over Time¹

Departments of Medicine (J.J., G.M.R.), Stanford University School of Medicine, Stanford, California 94305; San Francisco General Hospital and University of California San Francisco (F.F., M.H.H.), San Francisco, California 94110; and Shaman Pharmaceuticals (G.M.R.), Inc., South San Francisco, California 94080

Address all correspondence and requests for reprints to: G. M. Reaven, M.D., Shaman Pharmaceuticals, Inc., 213 East Grand Avenue, South San Francisco, California 94080-4812. E-mail: greaven{at}shaman.com

To evaluate the stability of insulin-mediated glucose disposal, over time, we measured the steady-state plasma insulin (SSPI) and steady-state plasma glucose (SSPG) concentrations in response to a continuous infusion of SRIF (5 µg/min), insulin (25 µU/m²·min), and dextrose (240 µg/m²·min). These measurements were made in 15 healthy volunteers, studied before and after a mean (±SEM) interval of 48 ± 2 months. The mean (±SEM) weight of the volunteers did not increase with time (75.4 ± 3.1 vs. 76.6 ± 3.2 kg), and there was no significant variation between the 2 mean (±SEM) values of either SSPI (324 ± 18 vs. 372 ± 24 pmol/L) or SSPG (8.4 ± 1.0 vs. 8.2 ± 1.0 mmol/L). Given the similarity of both SSPI and SSPG concentrations at baseline and follow-up, it can be concluded that insulin-mediated glucose disposal was stable in these 15 individuals over an interval of approximately 4 yr.

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