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Leptin Before and After Insulin Therapy in Children with New-Onset Type 1 Diabetes¹

Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Children’s Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213

Address all correspondence and requests for reprints to: Silva A. Arslanian, M.D., Division of Endocrinology, Children’s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213. E-mail: arslans{at}chplink.chp.edu

Serum leptin levels reflect the amount of body fat. However, several reports suggest that insulin may also regulate serum leptin levels. This study was aimed at testing whether leptin levels are low in newly diagnosed patients with type 1 diabetes and increase after institution of insulin therapy. Nineteen children with new-onset type 1 diabetes were studied. Serum leptin levels were measured at presentation before insulin therapy was initiated (day 0), 1 day after insulin therapy (day 1), 3–5 days after insulin therapy (day 3–5), and at 3 months of follow-up (3 months). The control group consisted of 19 healthy children matched for age and body mass index.

On day 0 leptin levels were lower in the patients compared with those in controls (3.3 ± 0.2 vs. 6.2 ± 0.9 ng/mL; P < 0.005). After insulin therapy, leptin levels increased significantly by day 1 without significant weight change and became comparable to control values by days 3–5. Before insulin therapy, leptin did not correlate with weight, body mass index, or hemoglobin A_1c. After insulin therapy, leptin levels on days 3–5 correlated with insulin dose (r = 0.43; P = 0.03). The results of this study demonstrate that children with new-onset type 1 diabetes have low leptin levels before insulin therapy. Leptin levels increase within 24 h of insulin therapy and become comparable to nondiabetic levels by 3–5 days. This rapid increase in leptin after 24 h of insulinization is independent of changes in body weight and is postulated to be due to a stimulatory effect of insulin on leptin production, nutritional replenishment, or both factors together.

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