help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hahn, T.
Right arrow Articles by Desoye, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hahn, T.
Right arrow Articles by Desoye, G.
The Journal of Clinical Endocrinology & Metabolism Vol. 84, No. 4 1445-1452
Copyright © 1999 by The Endocrine Society

Original Studies

Placental Glucose Transporter Expression Is Regulated by Glucocorticoids1

T. Hahn, S. Barth, R. Graf, M. Engelmann, D. Beslagic, J. M. H. M. Reul, F. Holsboer, G. Dohr and G. Desoye

Institute of Histology and Embryology (T.H., G.Do.) and the Institute of Hygiene (S.B.), University of Graz, A-8010 Graz, Austria; the Department of Obstetrics and Gynecology, University of Graz Medical School (T.H., G.De.), A-8036 Graz, Austria; the Institute of Anatomy, Free University of Berlin (R.G.), D-14195 Berlin, Germany; Max Planck Institute of Psychiatry (M.E., J.M.R., F.H.), D-80804 Munich, Germany; and the Department of Medicine, University of Queensland, Royal Brisbane Hospital (D.B.), Herston, Queensland 4029, Australia

Address all correspondence and requests for reprints to: Dr. Tom Hahn, Institute of Histology and Embryology, University of Graz, Harrachgasse 21, A-8010 Graz, Austria. E-mail: tom.hahn{at}kfunigraz.ac.at

Although glucocorticoids play important roles in development and fetal programming, they are widely used for treatment of a variety of diseases during pregnancy. In various tissues, glucocorticoids down-regulate glucose transport systems; however, their effects on glucose transporters in the placenta are unknown. In the present study, the glucose carrier proteins GLUT1 and GLUT3 were localized in the trophoblast and endothelium of the human, rat, and mouse placenta. Subsequently, it was investigated whether glucocorticoids affect messenger ribonucleic acid and protein expression of these molecules by Northern and Western blotting using 1) human term placental trophoblast cells cultured in the presence or absence of 0.5, 5, and 50 µmol/L triamcinolone; 2) placentas of rats that received a single ip dose of 0.38 mg/kg triamcinolone; and 3) placentas of transgenic mice bearing an antisense glucocorticoid receptor gene construct. In all of these systems, both glucose transporters were significantly down-regulated (P < 0.05), with the exception of increased GLUT3 messenger ribonucleic acid and protein levels in transgenic mice. The results demonstrate that triamcinolone is a potent regulator of placental GLUT1 and GLUT3 expression involving the glucocorticoid receptor. We speculate that impaired expression of placental glucose transporters after glucocorticoid administration might contribute to the adverse side-effects, the foremost of which is a growth-retarded fetus, of this treatment during pregnancy.




This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
A. E. Michael and A. T. Papageorghiou
Potential significance of physiological and pharmacological glucocorticoids in early pregnancy
Hum. Reprod. Update, September 1, 2008; 14(5): 497 - 517.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Umekawa, T. Sugiyama, T. Kihira, N. Murabayashi, L. Zhang, K. Nagao, Y. Kamimoto, N. Ma, J. Yodoi, and N. Sagawa
Overexpression of Thioredoxin-1 Reduces Oxidative Stress in the Placenta of Transgenic Mice and Promotes Fetal Growth via Glucose Metabolism
Endocrinology, August 1, 2008; 149(8): 3980 - 3988.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. U. Baumann, S. Zamudio, and N. P. Illsley
Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1
Am J Physiol Cell Physiol, July 1, 2007; 293(1): C477 - C485.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. Mairesse, J. Lesage, C. Breton, B. Breant, T. Hahn, M. Darnaudery, S. L. Dickson, J. Seckl, B. Blondeau, D. Vieau, et al.
Maternal stress alters endocrine function of the feto-placental unit in rats
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1526 - E1533.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M Mandl, N Ghaffari-Tabrizi, J Haas, G Nohammer, and G Desoye
Differential glucocorticoid effects on proliferation and invasion of human trophoblast cell lines
Reproduction, July 1, 2006; 132(1): 159 - 167.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. L. Fowden, J. W. Ward, F. P. B. Wooding, A. J. Forhead, and M. Constancia
Programming placental nutrient transport capacity
J. Physiol., April 1, 2006; 572(1): 5 - 15.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. Myatt
Placental adaptive responses and fetal programming
J. Physiol., April 1, 2006; 572(1): 25 - 30.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M.-J. Lee, Z. Wang, H. Yee, Y. Ma, N. Swenson, L. Yang, S. S. Kadner, R. N. Baergen, S. K. Logan, M. J. Garabedian, et al.
Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts
Endocrinology, November 1, 2005; 146(11): 4619 - 4626.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
A L Fowden and A J Forhead
Endocrine mechanisms of intrauterine programming
Reproduction, May 1, 2004; 127(5): 515 - 526.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
H. Li, Y. Gu, Y. Zhang, M. J. Lucas, and Y. Wang
High Glucose Levels Down-Regulate Glucose Transporter Expression That Correlates With Increased Oxidative Stress in Placental Trophoblast Cells IN Vitro
Reproductive Sciences, February 1, 2004; 11(2): 75 - 81.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
J. W. Ward, F. B. P. Wooding, and A. L. Fowden
Ovine feto-placental metabolism
J. Physiol., January 15, 2004; 554(2): 529 - 541.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. von Wolff, S. Ursel, U. Hahn, R. Steldinger, and T. Strowitzki
Glucose Transporter Proteins (GLUT) in Human Endometrium: Expression, Regulation, and Function throughout the Menstrual Cycle and in Early Pregnancy
J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3885 - 3892.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
C. Schlumbohm and J. Harmeyer
Hypocalcemia Reduces Endogenous Glucose Production in Hyperketonemic Sheep
J Dairy Sci, June 1, 2003; 86(6): 1953 - 1962.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
D. Hahn, A. Blaschitz, E.T. Korgun, I. Lang, G. Desoye, G. Skofitsch, and G. Dohr
From maternal glucose to fetal glycogen: expression of key regulators in the human placenta
Mol. Hum. Reprod., December 1, 2001; 7(12): 1173 - 1178.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
E. Turkay Korgun, R. Demir, A. Hammer, G. Dohr, G. Desoye, G. Skofitsch, and T. Hahn
Glucose Transporter Expression in Rat Embryo and Uterus During Decidualization, Implantation, and Early Postimplantation
Biol Reprod, November 1, 2001; 65(5): 1364 - 1370.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. D. Gluckman
Editorial: Nutrition, Glucocorticoids, Birth Size, and Adult Disease
Endocrinology, May 1, 2001; 142(5): 1689 - 1691.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1999 by The Endocrine Society