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Follicle-Stimulating Hormone-Inhibin B Interactions during the Follicular Phase of the Primate Menstrual Cycle Revealed by Gonadotropin-Releasing Hormone Antagonist and Antiestrogen Treatment

Medical Research Council Reproductive Biology Unit (H.M.F., A.S.M.), Centre for Reproductive Biology, Edinburgh EH3 9EW; and School of Biological and Molecular Sciences, Oxford Brookes University (N.P.G.), Oxford OX3 OBP, United Kingdom

Address all correspondence and requests for reprints to: Dr. H. M. Fraser, Medical Research Council Reproductive Biology Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9EW, United Kingdom. E-mail: h.fraser{at}ed-rbu.mrc.ac.uk

The aim was to determine the pattern of inhibin A and inhibin B secretion during the ovulatory cycle of the macaque and to explore the effects of manipulating follicular phase FSH on inhibin B secretion by: 1) blocking the early follicular phase rise in FSH with GnRH antagonist treatment; 2) administering FSH in GnRH antagonist-treated animals; and 3) preventing the midfollicular phase decline in FSH by a specific antiestrogen.

Treatment with GnRH antagonist, starting on day 25 of the cycle, abolished the early follicular phase rise in FSH and the associated increase in inhibin B. The same treatment, followed by exogenous FSH, restored the secretion of inhibin B. Treatment with antiestrogen, commencing during the midfollicular phase, induced a supraphysiological rise in FSH, followed by a marked stimulation of inhibin B and estradiol secretion. Despite continued antiestrogen treatment, FSH secretion declined before peak values of inhibin B and estradiol were attained, implying a potential endocrine role for inhibin B, in addition to estradiol, in the negative feedback regulation of FSH. These results show that follicular phase FSH is the major stimulus for inhibin B secretion.

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