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Original Studies |
1 Gene Polymorphism with Bone Density in Early Childhood1
Departments of Radiology (J.S., V.G.) and Pediatrics (J.M.V.T., F.K.), Childrens Hospital Los Angeles; Los Angeles, California 90027; Department of Biostatistics (J.S.), University of California Los Angeles School of Medicine, Los Angeles, California, 90024
Address correspondence and requests for reprints to: Vicente Gilsanz, M.D., Radiology Department, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, M.S.#81, Los Angeles, California 90027. E-mail: gilsanz{at}hsc.usc.edu
Osteoporosis is a disease characterized by the development of nontraumatic fractures, most commonly in the vertebrae of elderly women. Approximately 500,000 elderly women in the United States are newly diagnosed with vertebral fractures every year, as the compressive strength of the vertebra, mainly determined by the density of cancellous bone and its cross-sectional area, declines with age. A recent study in women suggested that a polymorphism in the Sp1 binding site of the collagen type I gene (COLIA1) was related to decreased vertebral bone mass and vertebral fractures. Determining the phenotypic trait(s) responsible for this relationship and whether this association is manifested in childhood would further define the structural basis for decreased bone mass and help identify children "at risk" for fractures later in life. We therefore studied the COLIA1 gene polymorphism and measurements of the size and the density of vertebral bone in 109 healthy, prepubertal girls. On average, 22 girls with the Ss genotype and one girl with the ss genotype had 6.7% and 49.4% lower cancellous bone density in the vertebrae than girls with the SS genotype. In contrast, there was no association between the size of the vertebrae and the COLIA1 genotypes.
This article has been cited by other articles:
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  V. Gilsanz and T. Wren Assessment of Bone Acquisition in Childhood and Adolescence Pediatrics, March 1, 2007; 119(Supplement_2): S145 - S149. [Abstract] [Full Text] [PDF]
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 J H Davies, B A J Evans, and J W Gregory Bone mass acquisition in healthy children Arch. Dis. Child., April 1, 2005; 90(4): 373 - 378. [Abstract] [Full Text] [PDF]
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 S M F Pluijm, H W van Essen, N Bravenboer, A G Uitterlinden, J H Smit, H A P Pols, and P Lips Collagen type I {alpha}1 Sp1 polymorphism, osteoporosis, and intervertebral disc degeneration in older men and women Ann Rheum Dis, January 1, 2004; 63(1): 71 - 77. [Abstract] [Full Text] [PDF]
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 M. Suuriniemi, A. Mahonen, V. Kovanen, M. Alen, and S. Cheng Relation of PvuII site polymorphism in the COL1A2 gene to the risk of fractures in prepubertal Finnish girls Physiol Genomics, August 15, 2003; 14(3): 217 - 224. [Abstract] [Full Text] [PDF]
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 L. A. Soyka, W. P. Fairfield, and A. Klibanski Hormonal Determinants and Disorders of Peak Bone Mass in Children J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 3951 - 3963. [Full Text]
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M. Luiza Loro, J. Sayre, T. F. Roe, M. I. Goran, F. R. Kaufman, and V. Gilsanz Early Identification of Children Predisposed to Low Peak Bone Mass and Osteoporosis Later in Life J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3908 - 3918. [Abstract] [Full Text]
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The Effects of Anorexia Nervosa on Bone Metabolism in Female Adolescents J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4489 - 4496. [Abstract] [Full Text]
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C. Tao, S. Garnett, V. Petrauskas, and C. T. Cowell No Association Was Found between Collagen {alpha}I Type 1 Gene and Bone Density in Prepubertal Children J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 4293a - 4294. [Full Text]
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