help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mauriège, P.
Right arrow Articles by Després, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mauriège, P.
Right arrow Articles by Després, J. P.
The Journal of Clinical Endocrinology & Metabolism Vol. 84, No. 2 736-742
Copyright © 1999 by The Endocrine Society

Original Studies

Is Visceral Adiposity a Significant Correlate of Subcutaneous Adipose Cell Lipolysis in Men?1

P. Mauriège, M. Brochu, D. Prud’homme, A. Tremblay, A. Nadeau, S. Lemieux and J. P. Després

Lipid Research Center, Laval University Medical Research Center (P.M., D.P., S.L., J.P.D.); Diabetes Research Unit, CHUL Medical Research Center (A.N.), and Physical Activity Sciences Laboratory (P.M., M.B., D.P., A.T.), Laval University, Ste-Foy, Quebec, Canada

Address all correspondence and requests for reprints to: Pascale Mauriège, Ph.D., Lipid Research Center, Laval University Medical Research Center, CHUL, 2705 boulevard Laurier, Ste-Foy, Quebec, Canada G1V 4G2.

The aim of the present study was to examine whether site differences in sc adipose tissue (AT) lipolysis may be considered a contributing factor to the altered metabolic risk profile of visceral compared to peripheral obese men once the concomitant variation in adipose cell size is taken into account. For this purpose, sc abdominal and femoral fat cell lipolytic responses were investigated in two groups of men (body mass index, 28 ± 2 kg/m2), aged 36 ± 3 yr, who were matched for both sc abdominal AT area (256 ± 64 cm2) and sc abdominal adipose cell weight (0.55 ± 0.08 µg lipid/cell) but were characterized by either a high (162 ± 29 cm2; n = 18) or a low (101 ± 21 cm2; n = 18) visceral AT deposition. The maximal lipolytic response to epinephrine or to isoproterenol (ß-adrenergic agonist) as well as the maximal antilipolytic effect of either epinephrine or clonidine ({alpha}2-adrenergic agonist) assessed in sc adipocytes were similar among men with low vs. high levels of visceral AT. However, the ß-adrenoceptor sensitivity was increased in sc abdominal adipose cells of individuals with a high visceral AT accumulation compared to those with a low intraabdominal fat deposition. Positive relationships were also found between the lipolytic sensitivity of sc abdominal adipocytes and plasma insulin concentrations measured in the fasting state and after an oral glucose load. These results suggest that variation in the degree of visceral adiposity in men does not seem to be associated with differences in regional adipose cell maximal lipolytic capacity once fat cell size is taken into account. However, the greater ß-adrenoceptor lipolytic sensitivity of sc abdominal adipocytes could be considered a significant correlate of the increased insulinemia observed among men characterized by high levels of visceral AT.




This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
V. Giusti, M. Suter, C. Verdumo, R. C. Gaillard, P. Burckhardt, and F. P. Pralong
Molecular Determinants of Human Adipose Tissue: Differences between Visceral and Subcutaneous Compartments in Obese Women
J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1379 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
D. J. Cuff, G. S. Meneilly, A. Martin, A. Ignaszewski, H. D. Tildesley, and J. J. Frohlich
Effective Exercise Modality to Reduce Insulin Resistance in Women With Type 2 Diabetes
Diabetes Care, November 1, 2003; 26(11): 2977 - 2982.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. D. Mittelman, G. W. Van Citters, E. L. Kirkman, and R. N. Bergman
Extreme Insulin Resistance of the Central Adipose Depot In Vivo
Diabetes, March 1, 2002; 51(3): 755 - 761.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. M. Sharma, T. Pischon, S. Hardt, I. Kunz, and F. C. Luft
Hypothesis: {beta}-Adrenergic Receptor Blockers and Weight Gain : A Systematic Analysis
Hypertension, February 1, 2001; 37(2): 250 - 254.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. A. Johnson, S. K. Fried, F. X. Pi-Sunyer, and J. B. Albu
Impaired insulin action in subcutaneous adipocytes from women with visceral obesity
Am J Physiol Endocrinol Metab, January 1, 2001; 280(1): E40 - E49.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1999 by The Endocrine Society