This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nishimura, M. Articles by Yoshimura, M. Search for Related Content PubMed PubMed Citation Articles by Nishimura, M. Articles by Yoshimura, M.

Increased Vitreous Concentrations of Human Hepatocyte Growth Factor in Proliferative Diabetic Retinopathy¹

Department of Clinical and Laboratory Medicine (M.N., M.U., A.N., M.Y.), Department of Ophthalmology (T.I., S.K.), Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan

Address all correspondence and requests for reprints to: Masato Nishimura, M.D., Department of Clinical and Laboratory Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto 602-0841, Japan. E-mail: nishim{at}labmed.kpu-m.ac.jp

Human hepatocyte GF (hHGF) has strong neoangiogenesis activity. The present study was designed to investigate the possible involvement of hHGF in neovascularization in proliferative diabetic retinopathy (PDR) by measuring vitreous hHGF concentrations. The mean vitreous hHGF concentration was higher in subjects with PDR (5.70 ± 0.68 ng/mL, n = 33) than in nondiabetic control subjects (1.50 ± 0.20 ng/mL, n = 18, P < 0.01), nondiabetic subjects with proliferative vitreoretinopathy (3.31 ± 0.57 ng//mL, n = 10, P < 0.05), or diabetic subjects without PDR (1.29 ± 0.28 ng/mL, n = 8, P < 0.01). PDR subjects with neovascularization of iris, which suggests advanced retinal ischemia, showed a higher mean vitreous hHGF concentration than those without iridal neovascularization [7.33 ± 1.16 ng/mL (n = 14) vs. 4.49 ± 0.72 ng/mL (n = 19), P < 0.05]. The mean vitreous hHGF concentration was higher in PDR subjects with retinal neovascularization at the optic disc than in those with neovascularization elsewhere [7.3 ± 1.1 ng/mL (n = 15) vs. 4.4 ± 0.7 ng/mL (n = 18), P < 0.05]. Our results indicate that vitreous hHGF may play a role in retinal neovascularization in PDR.

This article has been cited by other articles:

				A. C. Clermont, M. Cahill, H. Salti, S. L. Rook, C. Rask-Madsen, L. Goddard, J. S. Wong, D. Bursell, S. E. Bursell, and L. P. Aiello Hepatocyte Growth Factor Induces Retinal Vascular Permeability via MAP-Kinase and PI-3 Kinase without Altering Retinal Hemodynamics. Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2701 - 2708. [Abstract] [Full Text] [PDF]

				S. Machida, M. Tanaka, T. Ishii, K. Ohtaka, T. Takahashi, and Y. Tazawa Neuroprotective Effect of Hepatocyte Growth Factor against Photoreceptor Degeneration in Rats Invest. Ophthalmol. Vis. Sci., November 1, 2004; 45(11): 4174 - 4182. [Abstract] [Full Text] [PDF]

				R. Simo, A. Lecube, J. Garcia-Arumi, E. Carrasco, and C. Hernandez Hepatocyte Growth Factor in the Vitreous Fluid of Patients With Proliferative Diabetic Retinopathy: Its relationship with vascular endothelial growth factor and retinopathy activity Diabetes Care, January 1, 2004; 27(1): 287 - 288. [Full Text] [PDF]

				H. Shibuki, N. Katai, S. Kuroiwa, T. Kurokawa, J. Arai, K. Matsumoto, T. Nakamura, and N. Yoshimura Expression and Neuroprotective Effect of Hepatocyte Growth Factor in Retinal Ischemia-Reperfusion Injury Invest. Ophthalmol. Vis. Sci., February 1, 2002; 43(2): 528 - 536. [Abstract] [Full Text] [PDF]

				J. Troger, S. Neyer, C. Heufler, H. Huemer, E. Schmid, U. Griesser, M. Kralinger, B. Kremser, I. Baldissera, and G. Kieselbach Substance P and Vasoactive Intestinal Polypeptide in the Streptozotocin-Induced Diabetic Rat Retina Invest. Ophthalmol. Vis. Sci., April 1, 2001; 42(5): 1045 - 1050. [Abstract] [Full Text]

				M. C. Briggs, I. Grierson, P. Hiscott, and J. A. Hunt Active Scatter Factor (HGF/SF) in Proliferative Vitreoretinal Disease Invest. Ophthalmol. Vis. Sci., September 1, 2000; 41(10): 3085 - 3094. [Abstract] [Full Text]

				A. Cantón, R. Burgos, C. Hernández, C. Mateo, R. M Segura, J. Mesa, and R. Simó Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy Br. J. Ophthalmol., July 1, 2000; 84(7): 732 - 735. [Abstract] [Full Text]

				W. Cai, S. L. Rook, Z. Y. Jiang, N. Takahara, and L. P. Aiello Mechanisms of Hepatocyte Growth Factor-Induced Retinal Endothelial Cell Migration and Growth Invest. Ophthalmol. Vis. Sci., June 1, 2000; 41(7): 1885 - 1893. [Abstract] [Full Text]

				M. Nishimura, M. Ushiyama, K. Ohtsuka, M. Nishida, N. Inoue, A. Matsumuro, T. Mineo, and M. Yoshimura Serum Hepatocyte Growth Factor as a Possible Indicator of Vascular Lesions J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2475 - 2480. [Abstract] [Full Text]