This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McLaughlin, T. Articles by Reaven, G. Search for Related Content PubMed PubMed Citation Articles by McLaughlin, T. Articles by Reaven, G.

Differences in Insulin Resistance Do Not Predict Weight Loss in Response to Hypocaloric Diets in Healthy Obese Women¹

Department of Medicine, Stanford University School of Medicine, Stanford, California 94305; and Shaman Pharmaceuticals, Inc., South San Francisco, California 94080-4812

Address all correspondence and requests for reprints to: Gerald M. Reaven, M.D., Shaman Pharmaceuticals, Inc., 213 East Grand Avenue, South San Francisco, California 94080-4812. E-mail: greaven{at}shaman.com

The current study was initiated to determine whether insulin resistance and/or hyperinsulinemia affected the ability of obese individuals to lose weight in response to hypocaloric diets. Thirty-one obese, nondiabetic women, with values for body mass index ranging from 28.0–35.0 kg/m², volunteered for this program. Resistance to insulin-mediated glucose disposal was assessed by determining their steady state plasma insulin and glucose concentration during the last 30 min of a 180-min infusion of somatostatin, insulin, and glucose. The total integrated insulin response to breakfast and lunch was also determined. After the baseline measurements, volunteers were placed on a hypocaloric diet calculated to lead to a minimum weekly loss of 1% of ideal body weight. Individuals who met the criteria after 30 days of dieting were defined as weight loss successes (n = 20) and continued on the diet for another 30 days. Individuals not meeting the criteria were designated as weight loss failures (n = 12) and were discharged from the study. There was a mean (±SEM) weight loss at 60 days of 9.2 ± 0.4 kg in the 20 individuals defined as weight loss successes, but there was no correlation between weight loss and either steady state plasma glucose or the total integrated insulin response (r < 0.1; P > 0.83). Furthermore, using the same criteria to define insulin sensitivity and insulin resistance as those for therapeutic successes, the therapeutic failures comprised six insulin-sensitive and five insulin-resistant subjects. In summary, insulin-mediated glucose disposal varied widely in nondiabetic, obese women, and there was no relationship between baseline insulin resistance or total integrated insulin response and weight loss. It is concluded that the ability to lose weight on a calorie-restricted diet over a short time period does not vary in obese, healthy women as a function of insulin resistance or hyperinsulinemia.

This article has been cited by other articles:

				Z. T. Bloomgarden Gut Hormones, Obesity, Polycystic Ovarian Syndrome, Malignancy, and Lipodystrophy Syndromes Diabetes Care, July 1, 2007; 30(7): 1934 - 1939. [Full Text] [PDF]

				T. McLaughlin, F. Abbasi, C. Lamendola, and G. Reaven Heterogeneity in the Prevalence of Risk Factors for Cardiovascular Disease and Type 2 Diabetes Mellitus in Obese Individuals: Effect of Differences in Insulin Sensitivity Arch Intern Med, April 9, 2007; 167(7): 642 - 648. [Abstract] [Full Text] [PDF]

				R. S. Legro A 27-Year-Old Woman With a Diagnosis of Polycystic Ovary Syndrome JAMA, February 7, 2007; 297(5): 509 - 519. [Abstract] [Full Text] [PDF]

				P. K. Newby, C. Weismayer, A. Akesson, K. L. Tucker, and A. Wolk Longitudinal Changes in Food Patterns Predict Changes in Weight and Body Mass Index and the Effects Are Greatest in Obese Women J. Nutr., October 1, 2006; 136(10): 2580 - 2587. [Abstract] [Full Text] [PDF]

				Z. T. Bloomgarden Third Annual World Congress on the Insulin Resistance Syndrome: Mediators, antecedents, and measurement Diabetes Care, July 1, 2006; 29(7): 1700 - 1706. [Full Text] [PDF]

				A. G. Pittas, S. K. Das, C. L. Hajduk, J. Golden, E. Saltzman, P. C. Stark, A. S. Greenberg, and S. B. Roberts A Low-Glycemic Load Diet Facilitates Greater Weight Loss in Overweight Adults With High Insulin Secretion but Not in Overweight Adults With Low Insulin Secretion in the CALERIE Trial Diabetes Care, December 1, 2005; 28(12): 2939 - 2941. [Full Text] [PDF]

				M. Noakes, J. B Keogh, P. R Foster, and P. M Clifton Effect of an energy-restricted, high-protein, low-fat diet relative to a conventional high-carbohydrate, low-fat diet on weight loss, body composition, nutritional status, and markers of cardiovascular health in obese women Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1298 - 1306. [Abstract] [Full Text] [PDF]

				C. Lara-Castro and W. T. Garvey Diet, Insulin Resistance, and Obesity: Zoning in on Data for Atkins Dieters Living in South Beach J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4197 - 4205. [Abstract] [Full Text] [PDF]

				G. Reaven, F. Abbasi, and T. McLaughlin Obesity, Insulin Resistance, and Cardiovascular Disease Recent Prog. Horm. Res., January 1, 2004; 59(1): 207 - 223. [Abstract] [Full Text]

				T. McLaughlin, F. Abbasi, K. Cheal, J. Chu, C. Lamendola, and G. Reaven Use of Metabolic Markers To Identify Overweight Individuals Who Are Insulin Resistant Ann Intern Med, November 18, 2003; 139(10): 802 - 809. [Abstract] [Full Text] [PDF]

				C. Beebe Body Weight Issues in Preventing and Treating Type 2 Diabetes Diabetes Spectr, October 1, 2003; 16(4): 261 - 266. [Full Text] [PDF]

				E. J. Mayer-Davis, G. J. Kirkner, A. J. Karter, and D. J. Zaccaro Metabolic Predictors of 5-Year Change in Weight and Waist Circumference in a Triethnic Population: The Insulin Resistance Atherosclerosis Study Am. J. Epidemiol., April 1, 2003; 157(7): 592 - 601. [Abstract] [Full Text] [PDF]

				G. M. Reaven Importance of Identifying the Overweight Patient Who Will Benefit the Most by Losing Weight Ann Intern Med, March 4, 2003; 138(5): 420 - 423. [Abstract] [Full Text] [PDF]

				Z. T. Bloomgarden American Association of Clinical Endocrinologists (AACE) Consensus Conference on the Insulin Resistance Syndrome: 25-26 August 2002, Washington, DC Diabetes Care, March 1, 2003; 26(3): 933 - 939. [Full Text] [PDF]

				T. McLaughlin, F. Abbasi, C. Lamendola, L. Liang, G. Reaven, P. Schaaf, and P. Reaven Differentiation Between Obesity and Insulin Resistance in the Association With C-Reactive Protein Circulation, December 3, 2002; 106(23): 2908 - 2912. [Abstract] [Full Text] [PDF]

				F. Abbasi, B. W. Brown Jr, C. Lamendola, T. McLaughlin, and G. M. Reaven Relationship between obesity, insulin resistance, and coronary heart disease risk J. Am. Coll. Cardiol., September 4, 2002; 40(5): 937 - 943. [Abstract] [Full Text] [PDF]