This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nakanishi, K. Articles by Inoko, H. Search for Related Content PubMed PubMed Citation Articles by Nakanishi, K. Articles by Inoko, H.

Human Leukocyte Antigen-A24 and -DQA1¹0301 in Japanese Insulin-Dependent Diabetes Mellitus: Independent Contributions to Susceptibility to the Disease and Additive Contributions to Acceleration of ß-Cell Destruction^,1

Department of Endocrinology and Metabolism, Toranomon Hospital and Okinaka Memorial Institute for Medical Research (K.N., T.K., T.M.), Tokyo 105-8470, Japan; the Department of Molecular Life Science, Tokai University School of Medicine (T.N., H.I.), Isehara 259-1100; and the Hyogo Red Cross Blood Center (Y.N.), Kobe 651-0062, Japan

Address all correspondence and requests for reprints to: Koji Nakanishi, M.D, Department of Endocrinology and Metabolism, Toranomon Hospital, 2–2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan.

The aim of this study is to identify insulin-dependent diabetes mellitus (IDDM)-susceptible HLA antigens in IDDM patients who do not have established risk allele, HLA-DQA1*0301, and analyze relationship of these HLA antigens and the degree of ß-cell destruction.

In 139 Japanese IDDM patients and 158 normal controls, HLA-A, -C, -B, -DR and -DQ antigens were typed. Serum C-peptide immunoreactivity response (CPR) to a 100-g oral glucose load 0.033 nmol/l was regarded as complete ß-cell destruction.

All 14 patients without HLA-DQA1*0301 had HLA-A24, whereas only 35 of 58 (60.3%) normal controls without HLA-DQA1*0301 and only 72 of 125 (57.6%) IDDM patients with HLA-DQA1*0301 had this antigen (Pc = 0.0256 and Pc = 0.0080, respectively). CPR in IDDM patients with both HLA-DQA1*0301 and HLA-A24 (0.097 ± 0.163 nmol/L, mean ± SD, n = 65) were lower than in IDDM patients with HLA-DQA1*0301 only (0.219 ± 0.237 nmol/L, n = 45, P < 0.0001) and in IDDM patients with HLA-A24 only (0.187 ± 0.198 nmol/L, n = 14, P = 0.0395).

These results indicate that both HLA-DQA1*0301 and HLA-A24 contribute susceptibility to IDDM independently and accelerate ß-cell destruction in an additive manner.

This article has been cited by other articles:

				K. Nakanishi and H. Inoko Combination of HLA-A24, -DQA1*03, and -DR9 Contributes to Acute-Onset and Early Complete {beta}-Cell Destruction in Type 1 Diabetes: Longitudinal Study of Residual {beta}-Cell Function Diabetes, June 1, 2006; 55(6): 1862 - 1868. [Abstract] [Full Text] [PDF]

				T. Takaki, M. P. Marron, C. E. Mathews, S. T. Guttmann, R. Bottino, M. Trucco, T. P. DiLorenzo, and D. V. Serreze HLA-A*0201-Restricted T Cells from Humanized NOD Mice Recognize Autoantigens of Potential Clinical Relevance to Type 1 Diabetes. J. Immunol., March 1, 2006; 176(5): 3257 - 3265. [Abstract] [Full Text] [PDF]