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Expression of Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF) Related to Angiogenesis in Ovarian Endometriosis

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City 500-8705, Japan

Address all correspondence and requests for reprints to: Jiro Fujimoto, M.D., Ph.D., Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu City 500-8705, Japan.

Platelet-derived endothelial cell growth factor (PD-ECGF) is expressed in the lining epithelial cells of ovarian endometriomas, and in interstitial cells of the subepithelial area with angiogenesis. The expression of PD-ECGF persists in endometriotic endometrium during the menstrual cycle. This might suggest that PD-ECGF contributes to the growth of ovarian endometriomas via subepithelial angiogenesis independently of the sex steroidal milieu.

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