| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Original Studies |
Departments of Nuclear Medicine (L.L., L.D.P.F., D.L.G., T.D., C.G., A.A.), General and Gastrointestinal Surgery (F.M.), Pathology (C.H.), and Endocrinology (G.T.) and the Quantitative Medical Imaging Research Unit, INSERM U-494 (L.L., G.H., B.F., A.A.), Pitié Hospital, 75013 Paris; the Department of Pathology (B.F.), Ambroise Paré Hospital, 92100 Boulogne-Billancourt, France
Address all correspondence and requests for reprints to: Dr. L. Leenhardt, Service Central de Médecine Nucléaire, Groupe Hospitalier Pitié-Salpêtrière, 83 boulevard de l’Hôpital, 75013 Paris, France.
Although ultrasound (US)-guided fine needle aspiration biopsy (FNAB) is widely prescribed in nonpalpable thyroid nodules, the goal of this study was to define precisely the indications and limits of US-FNAB in a series of 450 nonpalpable nodules. Among 94 surgically controlled cases, 20 (8 infracentimetric and 12 centimetric or supracentimetric) carcinomas were diagnosed. The diagnosis of malignancy was successfully made by US-FNAB in 16 of 20 carcinomas, 3 were missed because of insufficient cytological material, and 1 was misdiagnosed. US-FNAB sensitivity and specificity were 94% and 63%, respectively. A logistic model indicated that nodule size (P < 0.6) was not associated with histological diagnosis, but that solid hypoechoic features were more likely to be malignant (P < 0.0003), with US sensitivity and specificity for malignancy of 80% and 70%, respectively. Logistic regression indicated that adequate cytological material significantly increased with nodule size (P < 0.0001). This result outlined the limits of US-FNAB in small nodules. Hence, indication of US-FNAB appears judicious in centimetric or supracentimetric nodules or in solid and hypoechoic ones. Such a management would allow the discovery of 15 of 20 carcinomas and would avoid 16% of unnecessary biopsies.
This article has been cited by other articles:
 |
|
 |
|
  B. Popowicz, M. Klencki, A. Lewinski, and D. Slowinska-Klencka The usefulness of sonographic features in selection of thyroid nodules for biopsy in relation to the nodule's size Eur. J. Endocrinol., July 1, 2009; 161(1): 103 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H M Mehanna, A Jain, R P Morton, J Watkinson, and A Shaha Investigating the thyroid nodule BMJ, March 13, 2009; 338(mar13_1): b733 - b733. [Full Text]
|
|
|
|
|
|
E. Roti, E. C degli Uberti, M. Bondanelli, and L. E Braverman Thyroid papillary microcarcinoma: a descriptive and meta-analysis study Eur. J. Endocrinol., December 1, 2008; 159(6): 659 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Slowinska-Klencka, B. Popowicz, A. Lewinski, S. Sporny, and M. Klencki The fine-needle aspiration biopsy efficacy of small thyroid nodules in the area of recently normalized iodine supply Eur. J. Endocrinol., December 1, 2008; 159(6): 747 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. E. Gulcelik, M. A. Gulcelik, and B. Kuru Risk of Malignancy in Patients With Follicular Neoplasm: Predictive Value of Clinical and Ultrasonographic Features Arch Otolaryngol Head Neck Surg, December 1, 2008; 134(12): 1312 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Erbil, U. Barbaros, A. Salmaslioglu, O. Mete, H. Issever, S. Ozarmagan, D. Yilmazbayhan, and S. Tezelman Effect of Thyroid Gland Volume in Preoperative Detection of Suspected Malignant Thyroid Nodules in a Multinodular Goiter Arch Surg, June 1, 2008; 143(6): 558 - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Yeung and J. W. Serpell Management of the Solitary Thyroid Nodule Oncologist, February 1, 2008; 13(2): 105 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Cappelli, I Pirola, M Castellano, E Gandossi, E De Martino, A Delbarba, B Agosti, A Tironi, and E A. Rosei Fine needle cytology of complex thyroid nodules Eur. J. Endocrinol., October 1, 2007; 157(4): 529 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Hollenbeak, I. Lendel, K. S. Beus, J. M. Ruda, and B. C. Stack Jr The Cost of Screening for Synchronous Thyroid Disease in Patients Presenting With Primary Hyperparathyroidism Arch Otolaryngol Head Neck Surg, October 1, 2007; 133(10): 1013 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Jones, R Spendiff, S Fareedi, and P S Richards The role of ultrasound in the management of nodular thyroid disease Imaging, March 1, 2007; 19(1): 28 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cappelli, M. Castellano, I. Pirola, D. Cumetti, B. Agosti, E. Gandossi, and E. Agabiti Rosei The predictive value of ultrasound findings in the management of thyroid nodules QJM, January 1, 2007; 100(1): 29 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cappelli, M. Castellano, I. Pirola, E. Gandossi, E. De Martino, D. Cumetti, B. Agosti, and E. A. Rosei Thyroid nodule shape suggests malignancy. Eur. J. Endocrinol., July 1, 2006; 155(1): 27 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Niedziela Pathogenesis, diagnosis and management of thyroid nodules in children. Endocr. Relat. Cancer, June 1, 2006; 13(2): 427 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Steele, M. J. Martin, P. S. Mullenix, K. S. Azarow, and C. A. Andersen The Significance of Incidental Thyroid Abnormalities Identified During Carotid Duplex Ultrasonography Arch Surg, October 1, 2005; 140(10): 981 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lyshchik, V. Drozd, Y. Demidchik, and C. Reiners Diagnosis of Thyroid Cancer in Children: Value of Gray-Scale and Power Doppler US Radiology, May 1, 2005; 235(2): 604 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Wienke, W. K. Chong, J. R. Fielding, K. H. Zou, and C. A. Mittelstaedt Sonographic Features of Benign Thyroid Nodules: Interobserver Reliability and Overlap With Malignancy J. Ultrasound Med., October 1, 2003; 22(10): 1027 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Hegedus, S. J. Bonnema, and F. N. Bennedbaek Management of Simple Nodular Goiter: Current Status and Future Perspectives Endocr. Rev., February 1, 2003; 24(1): 102 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Alexander, J. P. Heering, C. B. Benson, M. C. Frates, P. M. Doubilet, E. S. Cibas, and E. Marqusee Assessment of Nondiagnostic Ultrasound-Guided Fine Needle Aspirations of Thyroid Nodules J. Clin. Endocrinol. Metab., November 1, 2002; 87(11): 4924 - 4927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Ross Nonpalpable Thyroid Nodules--Managing an Epidemic J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 1938 - 1940. [Full Text] [PDF]
|
|
|
|
|
|
E. Papini, R. Guglielmi, A. Bianchini, A. Crescenzi, S. Taccogna, F. Nardi, C. Panunzi, R. Rinaldi, V. Toscano, and C. M. Pacella Risk of Malignancy in Nonpalpable Thyroid Nodules: Predictive Value of Ultrasound and Color-Doppler Features J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 1941 - 1946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Corrias, S. Einaudi, E. Chiorboli, G. Weber, A. Crino, M. Andreo, G. Cesaretti, L. de Sanctis, M. F. Messina, M. Segni, et al. Accuracy of Fine Needle Aspiration Biopsy of Thyroid Nodules in Detecting Malignancy in Childhood: Comparison with Conventional Clinical, Laboratory, and Imaging Approaches J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4644 - 4648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Samuels Editorial: Evaluation and Treatment of Sporadic Nontoxic Goiter--Some Answers and More Questions J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 994 - 997. [Full Text]
|
|
|
|
 |
|
 E. Marqusee, C. B. Benson, M. C. Frates, P. M. Doubilet, P. R. Larsen, E. S. Cibas, and S. J. Mandel Usefulness of Ultrasonography in the Management of Nodular Thyroid Disease Ann Intern Med, November 7, 2000; 133(9): 696 - 700. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
