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The Journal of Clinical Endocrinology & Metabolism Vol. 83, No. 8 2993-2996
Copyright © 1998 by The Endocrine Society

Original Studies

Variations in the Vitamin D-Binding Protein (Gc Locus) Are Associated with Oral Glucose Tolerance in Nondiabetic Pima Indians

Leslie J. Baier, Angela M. Dobberfuhl, Richard E. Pratley, Robert L. Hanson and Clifton Bogardus

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016

Address all correspondence and requests for reprints to: Dr. Leslie Baier, Clinical Diabetes and Nutrition Section, National Institutes of Health, 4212 North 16th Street, Phoenix, Arizona 85016. E-mail: lbaier{at}phx.niddk.nih.gov

Electrophoretic variants of the vitamin D-binding protein (DBP) have been associated with type 2 diabetes as well as with metabolic characteristics that predispose to type 2 diabetes in several populations. The Gc gene that encodes DBP maps to chromosome 4q12, a region that has recently been found to be potentially linked to plasma glucose and insulin concentrations in Pima Indians. Therefore, the gene that encodes DBP was analyzed as a candidate gene for our linkage findings in the Pima Indians. Sequence analysis of the coding exons identified two previously described missense polymorphisms at codons 416 and 420, which are the genetic basis for the three common electrophoretic variants of DBP (Gc1f, Gc1s, and Gc2). These variants in DBP were associated with differences in oral glucose tolerance in nondiabetic Pima Indians.




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Copyright © 1998 by The Endocrine Society