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Cedars-Sinai Research Institute, University of California School of Medicine (S.M.), Los Angeles, California 90048; Rhode Island Hospital/Brown University School of Medicine (I.J.), Providence, Rhode Island 02903; New York University Medical Center (D.K.), New York, New York 10016; and Neuroendocrine Clinical Center, Massachusetts General Hospital, Harvard Medical School (A.K.), Boston, Massachusetts 02114
Address all correspondence and requests for reprints to: Dr. Shlomo Melmed, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Room B-131, Los Angeles, California 90048-1865.
Acromegaly, an indolent disorder of growth hormone (GH) hypersecretion is most typically caused by a somatotroph cell adenoma and may be treated by several modalities. Transsphenoidal surgical resection of micro-adenomas by experienced neurosurgeons results in biochemical normalization (postglucose GH <2 ng/mL, assay-dependent, age- and sex-matched IGF-I levels) in 70% of patients. However, over 65% of GH-secreting adenomas are invasive or macroadenomas, and over 50% of these patients have persistent postoperative GH hypersecretion. Irradiation of adenomas results in attenuation of GH secretion to more than 5 ng/mL in 50% of subjects after 12 yr. However, the percent of parents who normalize IGF-I levels is less certain. Most of these patients develop associated pituitary failure and rarely develop other local adverse effects. About 60% of patients receiving somatostatin analogs achieve normalized IGF-I levels. Efficacy of medical management with somatostatin analogs may be improved by increasing injection frequency, changing delivery modes to depot preparations, and in the future, development of novel SRIF receptor subtype-specific analogs. An integrated approach to acromegaly management based upon relative risks and benefits of the currently available therapeutic modes is presented that allows for a national individualized strategy designed to achieve maximal biochemical control of GH hypersecretion and elevated IGF-I levels.
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S. Melmed Tight Control of Growth Hormone: An Attainable Outcome for Acromegaly Treatment J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3409 - 3410. [Full Text]
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