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The Journal of Clinical Endocrinology & Metabolism Vol. 83, No. 7 2493-2496
Copyright © 1998 by The Endocrine Society

Original Studies

Iodide Symporter Gene Expression in Human Thyroid Tumors1

Franco Arturi, Diego Russo, Martin Schlumberger, Jean-Antoine du Villard, Bernard Caillou, Paolo Vigneri, René Wicker, Eusebio Chiefari, Horacio G. Suarez and Sebastiano Filetti

Cattedra di Endocrinologia, Dipartimento di Medicina Sperimentale e Clinica (F.A., E.C., S.F.), and Cattedra di Farmacologia, Facoltà di Farmacia (D.R.), Università di Catanzaro, 88100 Catanzaro; and Oncologia Sperimentale, Istituto Nazionale Tumori (P.V.), Milan, Italy; and Institut de Recherches Scientifiques sur le Cancer, Centre National de Recherches Scientifiques (J.-A.D., R.W., H.G.S.), 94802 Villejuif; and Institut Gustave Roussy (M.S., B.C.), 94805 Villejuif, France

Address all correspondence and requests for reprints to: Sebastiano Filetti, M.D., Cattedra di Endocrinologia, Dipartimento di Medicina Sperimentale e Clinica, Via T. Campanella, 88100 Catanzaro, Italy. E-mail: filetti{at}tin.it

Expression of the Na+/I- symporter (NIS) gene was investigated by RT-PCR in a selected series of 26 primary thyroid carcinomas (19 papillary, 5 follicular, and 2 anaplastic). Fifteen follicular adenomas (11 "cold " and 4 "hot" adenomas) were also studied. Five of 19 papillary thyroid cancer did not express NIS messenger ribonucleic acid (mRNA). In all but 1 follicular cancer, NIS transcript was fully detected. In anaplastic tissue, NIS mRNA was only barely detected in 1 case. All of the follicular thyroid adenomas except 1 expressed the NIS gene. In contrast, all tumors studied excluding the anaplastic histotype fully expressed thyroglobulin and thyroid peroxidase mRNA transcripts. In 2 patients, a lower expression (3- to 5-fold) of NIS mRNA was found in metastasis by dot blot analysis compared with those in both normal and primary neoplastic thyroid tissue. Four of 8 differentiated thyroid cancer patients selected for the presence of metastases with negative posttherapy 131I total body scan showed the lack of NIS gene expression in their primary cancer. This defect, at least in these cases, is a somatic and intrinsic lesion of the primary cancer cells and is not due to a dedifferentiation process in the metastatic tissue. The early detection of the loss of NIS gene expression in the primary cancer, therefore, may provide useful information for the management of differentiated thyroid cancer patients.




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