This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ueda, S. Articles by Connell, J. M. C. Search for Related Content PubMed PubMed Citation Articles by Ueda, S. Articles by Connell, J. M. C. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB GLUCOSE

The Vasodilating Effect of Insulin Is Dependent on Local Glucose Uptake: A Double Blind, Placebo-Controlled Study¹

University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland G11 6NT

Address all correspondence and requests for reprints to: Dr. Shinichiro Ueda, Second Department of Medicine, Yokohama City University School of Medicine, 3–9 Fuku-ura, Kanazawa-ku, Yokohama 236, Japan. E-mail: sueda{at}med.yokohama-cu.ac.jp

During systemic hyperinsulinemia in man, skeletal muscle vasodilation has consistently been demonstrated. However, most studies that have examined the vascular effect of local hyperinsulinemia have reported either no effect or only weak vasodilation, and all of these have been open in design. The present studies were designed in a double blind, placebo-controlled manner to evaluate the direct (local) vascular effect of insulin alone and in association with physiological concentrations of D-glucose. Forearm blood flow was measured in 17 healthy male volunteers by bilateral venous occlusion forearm plethysmography. Brachial artery infusions of 1 mU/min insulin, 5 mU/min insulin, or vehicle were administered for 90 min on 3 separate study days in random order. The higher dose of insulin was associated with weak (20%) vasodilation compared with placebo (F = 5.75 and P < 0.01, by ANOVA). When this protocol was repeated with intraarterial coinfusion of D-glucose, significant augmentation of the vascular effect was demonstrated (47% vasodilation). No augmentation of insulin-mediated vasodilation was observed with coinfusion of L-glucose, the metabolically inactive stereoisomer. These data suggest that local uptake of D-glucose by insulin-sensitive tissues is an important determinant of insulin-mediated vasodilation.

This article has been cited by other articles:

				R. Muniyappa, M. Montagnani, K. K. Koh, and M. J. Quon Cardiovascular Actions of Insulin Endocr. Rev., August 1, 2007; 28(5): 463 - 491. [Abstract] [Full Text] [PDF]

				T. S. Perlstein, M. Gerhard-Herman, N. K. Hollenberg, G. H. Williams, and A. Thomas Insulin Induces Renal Vasodilation, Increases Plasma Renin Activity, and Sensitizes the Renal Vasculature to Angiotensin Receptor Blockade in Healthy Subjects J. Am. Soc. Nephrol., March 1, 2007; 18(3): 944 - 951. [Abstract] [Full Text] [PDF]

				M. Sjostrand, S. Gudbjornsdottir, L. Strindberg, and P. Lonnroth Delayed Transcapillary Delivery of Insulin to Muscle Interstitial Fluid After Oral Glucose Load in Obese Subjects Diabetes, January 1, 2005; 54(1): 152 - 157. [Abstract] [Full Text] [PDF]

				S Jadhav, J Petrie, W Ferrell, S Cobbe, and N Sattar Insulin resistance as a contributor to myocardial ischaemia independent of obstructive coronary atheroma: a role for insulin sensitisation? Heart, December 1, 2004; 90(12): 1379 - 1383. [Abstract] [Full Text] [PDF]

				V. Randriamboavonjy, J. Schrader, R. Busse, and I. Fleming Insulin Induces the Release of Vasodilator Compounds From Platelets by a Nitric Oxide-G Kinase-VAMP-3-dependent Pathway J. Exp. Med., February 2, 2004; 199(3): 347 - 356. [Abstract] [Full Text] [PDF]

				M. G. Clark, M. G. Wallis, E. J. Barrett, M. A. Vincent, S. M. Richards, L. H. Clerk, and S. Rattigan Blood flow and muscle metabolism: a focus on insulin action Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E241 - E258. [Abstract] [Full Text] [PDF]

				C. Rask-Madsen, N. Ihlemann, T. Krarup, E. Christiansen, L. Kober, C. Nervil Kistorp, and C. Torp-Pedersen Insulin Therapy Improves Insulin-Stimulated Endothelial Function in Patients With Type 2 Diabetes and Ischemic Heart Disease Diabetes, November 1, 2001; 50(11): 2611 - 2618. [Abstract] [Full Text] [PDF]

				K. Mather, M. Laakso, S. Edelman, G. Hook, and A. Baron Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1264 - E1270. [Abstract] [Full Text] [PDF]

				S. J. Cleland, J. R. Petrie, M. Small, H. L. Elliott, and J. M. C. Connell Insulin Action Is Associated With Endothelial Function in Hypertension and Type 2 Diabetes Hypertension, January 1, 2000; 35(1): 507 - 511. [Abstract] [Full Text] [PDF]

				S. Ueda, J. R. Petrie, S. J. Cleland, H. L. Elliott, J. M.C. Connell, C. Cardillo, and J. A. Panza Vasodilator Response to Local Hyperinsulinemia • Response Hypertension, December 1, 1999; 34 (6): e12 - e13. [Full Text] [PDF]

				N. J. Brown, J. V. Gainer, C. M. Stein, and D. E. Vaughan Bradykinin Stimulates Tissue Plasminogen Activator Release in Human Vasculature Hypertension, June 1, 1999; 33(6): 1431 - 1435. [Abstract] [Full Text] [PDF]

				K. Zierler Whole body glucose metabolism Am J Physiol Endocrinol Metab, March 1, 1999; 276(3): E409 - E426. [Abstract] [Full Text] [PDF]

				S. J. Cleland, J. R. Petrie, S. Ueda, H. L. Elliott, and J. M. C. Connell Insulin-Mediated Vasodilation and Glucose Uptake Are Functionally Linked in Humans Hypertension, January 1, 1999; 33(1): 554 - 558. [Abstract] [Full Text] [PDF]