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High Frequency of Rearrangement of the RET Protooncogene (RET/PTC) in Chinese Papillary Thyroid Carcinomas¹

Institute of Biomedical Sciences (G.-D.C., J.-Y.C.), Academia Sinica; Graduate Institute of Life Sciences (L.-S.H.), National Defense Medical Center; Departments of Surgery (C.-H.L.), Medical Research (C.-W.C.), and Pathology (A.-H.Y.), Veterans General Hospital-Taipei and National Yang-Ming University (C.-H.L., C.-W.C., A.-H.Y., J.-Y.C.), Taipei 11529, Taiwan, Republic of China

Address all correspondence and requests for reprints to: Dr. Jeou-Yuan Chen, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan. E-mail: bmchen{at}ibms.sinica.edu.tw

The activation of RET protooncogene, through chromosomal translocation, is unique to papillary thyroid carcinomas. Rearrangement of the RET kinase domain to 3 partner genes has been described, of which the RET/PTC1 is the most common. To investigate the frequency of RET rearrangement in Chinese papillary thyroid carcinomas, we have performed RT-PCR to amplify specific RET/PTC transcripts. Among the papillary thyroid carcinomas of 11 patients examined, we have identified 2 containing RET/PTC1, 3 containing RET/PTC2, and 1 containing RET/PTC3 oncogenes. Although the cause of the high frequency of RET/PTC oncogenes in Chinese papillary thyroid carcinomas is unknown, our study suggests that RET rearrangement is an important genetic lesion underlying the development of thyroid papillary carcinoma in Taiwan.

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