This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McCanlies, E. Articles by Dorman, J. S. Search for Related Content PubMed PubMed Citation Articles by McCanlies, E. Articles by Dorman, J. S.

Hashimoto’s Thyroiditis and Insulin-Dependent Diabetes Mellitus: Differences among Individuals with and without Abnormal Thyroid Function¹

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh (E.M., L.A.O., M.K.K., J.P.B., J.S.S., A.R.S., J.S.D.), Pittsburgh, Pennsylvania 15261; the Department of Pediatrics, University of Pittsburgh School of Medicine (T.P.F., M.T.), Pittsburgh, Pennsylvania 15261; the Faculty of Medical Sciences, National University of Rosario (A.L.), Rosario 2000, Argentina; and the Department of Epidemiology, University of Illinois School of Public Health (B.J.M.), Chicago, Illinois 60612

Address all correspondence and requests for reprints to: Janice S. Dorman, Ph.D., Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261. E-mail: jsd{at}vms.cis.pitt.edu

Insulin-dependent diabetes mellitus probands from the Familial Autoimmune and Diabetes Study were evaluated for autoimmune thyroid disease (n = 265). The prevalence of Hashimoto’s thyroiditis was 26.6%; 42.0% of these individuals were euthyroid, and 58.0% were hypothyroid. There was a female predominance among hypothyroid and euthyroid Hashimoto’s cases compared to those with no thyroid disease (75% vs. 72.4% vs. 41.6%; P < 0.001). Insulin-dependent diabetes mellitus patients with hypothyroid Hashimoto’s thyroiditis were more likely to report another autoimmune disease compared to euthyroid Hashimoto’s patients or individuals with no thyroid disease (30.8% vs. 17.2% vs. 13.9%; P < 0.01). Sex-specific analysis revealed that this difference was significant for men but not for women. Both euthyroid and hypothyroid Hashimoto’s cases were more likely to have a family history of the disease (66.7% vs. 69.2% vs. 47.7%; P < 0.05). No differences were observed in the prevalence of DQA1*0501-DQB1*0201 or DQA1*0301-DQB1*0302 across the three groups. Body mass index, lipid levels, glycemic control, and diabetes complications were also similar. However, euthyroid Hashimoto’s women were more likely to report spontaneous abortions than those with hypothyroid Hashimoto’s thyroiditis or no thyroid disease (23.8% vs. 61.5% vs. 29.1%; P < 0.05). These data suggest that gender-specific risk factors may be primary determinants of Hashimoto’s thyroiditis and other autoimmune diseases among women. However, disease-specific determinants may also increase susceptibility to other autoimmune diseases.

This article has been cited by other articles:

				Subsection Reports J. Clin. Endocrinol. Metab., August 1, 2007; 92(8_suppl): s8 - s47. [Full Text] [PDF]

				M. Abalovich, N. Amino, L. A. Barbour, R. H. Cobin, L. J. De Groot, D. Glinoer, S. J. Mandel, and A. Stagnaro-Green Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline J. Clin. Endocrinol. Metab., August 1, 2007; 92(8_suppl): s1 - s47. [Abstract] [Full Text] [PDF]

				S. J. Glastras, M. E. Craig, C. F. Verge, A. K. Chan, J. M. Cusumano, and K. C. Donaghue The Role of Autoimmunity at Diagnosis of Type 1 Diabetes in the Development of Thyroid and Celiac Disease and Microvascular Complications Diabetes Care, September 1, 2005; 28(9): 2170 - 2175. [Abstract] [Full Text] [PDF]

				J. P. Walsh, A. P. Bremner, M. K. Bulsara, P. O'Leary, P. J. Leedman, P. Feddema, and V. Michelangeli Parity and the Risk of Autoimmune Thyroid Disease: A Community-Based Study J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5309 - 5312. [Abstract] [Full Text] [PDF]

				B. Golden, L. Levin, Y. Ban, E. Concepcion, D. A. Greenberg, and Y. Tomer Genetic Analysis of Families with Autoimmune Diabetes and Thyroiditis: Evidence for Common and Unique Genes J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4904 - 4911. [Abstract] [Full Text] [PDF]

				O Kordonouri, R Hartmann, D Deiss, M Wilms, and A Gruters-Kieslich Natural course of autoimmune thyroiditis in type 1 diabetes: association with gender, age, diabetes duration, and puberty Arch. Dis. Child., April 1, 2005; 90(4): 411 - 414. [Abstract] [Full Text] [PDF]

				O. Dizdar, S. Kahraman, G. Genctoy, D. Ertoy, M. Arici, B. Altun, U. Yasavul, and C. Turgan Membranoproliferative glomerulonephritis associated with type 1 diabetes mellitus and Hashimoto's thyroiditis Nephrol. Dial. Transplant., April 1, 2004; 19(4): 988 - 989. [Full Text] [PDF]

				Y. Tomer and T. F. Davies Searching for the Autoimmune Thyroid Disease Susceptibility Genes: From Gene Mapping to Gene Function Endocr. Rev., October 1, 2003; 24(5): 694 - 717. [Abstract] [Full Text] [PDF]

				E. S. Strotmeyer, A. R. Steenkiste, T. P. Foley Jr, S. L. Berga, and J. S. Dorman Menstrual Cycle Differences Between Women With Type 1 Diabetes and Women Without Diabetes Diabetes Care, April 1, 2003; 26(4): 1016 - 1021. [Abstract] [Full Text] [PDF]

				A. Hanukoglu, A. Mizrachi, I. Dalal, O. Admoni, Y. Rakover, Z. Bistritzer, A. Levine, E. Somekh, D. Lehmann, M. Tuval, et al. Extrapancreatic Autoimmune Manifestations in Type 1 Diabetes Patients and Their First-Degree Relatives: A multicenter study Diabetes Care, April 1, 2003; 26(4): 1235 - 1240. [Abstract] [Full Text] [PDF]

				A. L. Lethagen, U.-B. Ericsson, B. Hallengren, L. Groop, and T. Tuomi Glutamic Acid Decarboxylase Antibody Positivity Is Associated with an Impaired Insulin Response to Glucose and Arginine in Nondiabetic Patients with Autoimmune Thyroiditis J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1177 - 1183. [Abstract] [Full Text] [PDF]

				J. S. Dorman, A. R. Steenkiste, T. P. Foley, E. S. Strotmeyer, J. P. Burke, L. H. Kuller, and C. K. Kwoh Menopause in Type 1 Diabetic Women: Is it Premature? Diabetes, August 1, 2001; 50(8): 1857 - 1862. [Abstract] [Full Text] [PDF]

				S. Winer, I. Astsaturov, R. K. Cheung, L. Gunaratnam, V. Kubiak, M. A. Cortez, M. Moscarello, P. W. O'Connor, C. McKerlie, D. J. Becker, et al. Type I Diabetes and Multiple Sclerosis Patients Target Islet Plus Central Nervous System Autoantigens; Nonimmunized Nonobese Diabetic Mice Can Develop Autoimmune Encephalitis J. Immunol., February 15, 2001; 166(4): 2831 - 2841. [Abstract] [Full Text] [PDF]