| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Original Studies |
Geneva, Switzerland
Address all correspondence and requests for reprints to: Ares-Serono Scientific and Medical Communications Department, 15 bis Chemin des Mines, CH-1202 Geneva, Switzerland.
The efficacy of recombinant human LH (rhLH) for supporting human
(rhFSH)-induced follicular development was investigated in
hypogonadotropic hypogonadal women (WHO group I anovulation). Patients
(n = 38) were randomized to receive rhLH (0, 25, 75, or 225
IU/day) in addition to a fixed dose of rhFSH (150 IU/day). rhLH was
found 1) to promote dose-related increases in estradiol
(E2) and androstenedione secretion by rhFSH-induced
follicles, i.e. serum concentrations on the last day of
FSH administration were 65 ± 4, 195 ± 94, 1392 ± 585,
and 2441 ± 904 pmol/L for E2 and 3.6 ± 0.9,
5.1 ± 1.3, 6.4 ± 1.3, and 6.7 ± 1.3 nmol/L for
androstenedione for patients treated with 0, 25, 75, and 225 IU rhLH,
respectively; 2) to increase ovarian sensitivity to FSH, as
demonstrated by the proportion of patients who developed follicles
after the administration of a fixed dose of FSH, i.e. 1
of 8, 3 of 7, 7 of 9, and 8 of 10 in patients treated with 0, 25, 75,
and 225 IU rhLH, respectively; and 3) to enhance the ability of these
follicles to luteinize when exposed to hCG. A daily dose of 75 IU rhLH
was effective in the majority of women in promoting optimal follicular
development (defined as 
1 follicle 17 mm; E2, 400
pmol/L; midluteal phase progesterone, 25 nmol/L) and maximal
endometrial growth. A minority of patients may require up to 225
IU/day. rhLH, given sc at a dose up to 225 IU/day, was not immunogenic
and was well tolerated.
This article has been cited by other articles:
 |
|
 |
|
  J. Balasch, F. Fabregues, F. Carmona, R. Casamitjana, and M. Tena-Sempere Ovarian Luteinizing Hormone Priming Preceding Follicle-Stimulating Hormone Stimulation: Clinical and Endocrine Effects in Women with Long-Term Hypogonadotropic Hypogonadism J. Clin. Endocrinol. Metab., July 1, 2009; 94(7): 2367 - 2373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. I. Durnerin, K. Erb, R. Fleming, H. Hillier, S.G. Hillier, C.M. Howles, J.-N. Hugues, A. Lass, H. Lyall, P. Rasmussen, et al. Effects of recombinant LH treatment on folliculogenesis and responsiveness to FSH stimulation Hum. Reprod., February 1, 2008; 23(2): 421 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Smitz, A.N. Andersen, P. Devroey, J.-C. Arce, and for the MERIT Group Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients Hum. Reprod., March 1, 2007; 22(3): 676 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lahoud, M.A. Jefout, J. Tyler, J. Ryan, and G. Driscoll A relative reduction in mid-follicular LH concentrations during GnRH agonist IVF/ICSI cycles leads to lower live birth rates Hum. Reprod., October 1, 2006; 21(10): 2645 - 2649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Macklon, R. L. Stouffer, L. C. Giudice, and B. C. J. M. Fauser The Science behind 25 Years of Ovarian Stimulation for in Vitro Fertilization Endocr. Rev., April 1, 2006; 27(2): 170 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.M. Kolibianakis, J. Collins, B. Tarlatzis, E. Papanikolaou, and P. Devroey Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review Hum. Reprod. Update, January 1, 2006; 12(1): 3 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Tarlatzis, E. Tavmergen, M. Szamatowicz, A. Barash, A. Amit, E. Levitas, and Z. Shoham The use of recombinant human LH (lutropin alfa) in the late stimulation phase of assisted reproduction cycles: a double-blind, randomized, prospective study Hum. Reprod., January 1, 2006; 21(1): 90 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. E. Messinis Ovulation induction: a mini review Hum. Reprod., October 1, 2005; 20(10): 2688 - 2697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Griesinger, A. Schultze-Mosgau, K. Dafopoulos, A. Schroeder, A. Schroer, S. von Otte, D. Hornung, K. Diedrich, and R. Felberbaum Recombinant luteinizing hormone supplementation to recombinant follicle-stimulating hormone induced ovarian hyperstimulation in the GnRH-antagonist multiple-dose protocol Hum. Reprod., May 1, 2005; 20(5): 1200 - 1206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.N. Hugues, J. Soussis, I. Calderon, J. Balasch, R.A. Anderson, A. Romeu, and on behalf of the Recombinant LH Study Group Does the addition of recombinant LH in WHO group II anovulatory women over-responding to FSH treatment reduce the number of developing follicles? A dose-finding study Hum. Reprod., March 1, 2005; 20(3): 629 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A.F. Huirne, A. C.D. van Loenen, R. Schats, J. McDonnell, P. G.A. Hompes, J. Schoemaker, R. Homburg, and C. B. Lambalk Dose-finding study of daily GnRH antagonist for the prevention of premature LH surges in IVF/ICSI patients: optimal changes in LH and progesterone for clinical pregnancy Hum. Reprod., February 1, 2005; 20(2): 359 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Cedrin-Durnerin, D. Grange-Dujardin, A. Laffy, I. Parneix, N. Massin, J. Galey, L. Theron, J.P. Wolf, C. Conord, P. Clement, et al. Recombinant human LH supplementation during GnRH antagonist administration in IVF/ICSI cycles: a prospective randomized study Hum. Reprod., September 1, 2004; 19(9): 1979 - 1984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Kolibianakis, C. Albano, M. Camus, H. Tournaye, A. C. Van Steirteghem, and P. Devroey Initiation of Gonadotropin-Releasing Hormone Antagonist on Day 1 as Compared to Day 6 of Stimulation: Effect on Hormonal Levels and Follicular Development in in Vitro Fertilization Cycles J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5632 - 5637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Young, C. L. Chaffin, T. A. Molskness, and R. L. Stouffer Controlled ovulation of the dominant follicle: a critical role for LH in the late follicular phase of the menstrual cycle Hum. Reprod., November 1, 2003; 18(11): 2257 - 2263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Filicori, G. E. Cognigni, and W. Ciampaglia What clinical evidence for an LH ceiling? Hum. Reprod., July 1, 2003; 18(7): 1556 - 1557. [Full Text] [PDF]
|
|
|
|
|
|
Z. Kilani, A. Dakkak, S. Ghunaim, G.E. Cognigni, C. Tabarelli, L. Parmegiani, and M. Filicori A prospective, randomized, controlled trial comparing highly purified hMG with recombinant FSH in women undergoing ICSI: ovarian response and clinical outcomes Hum. Reprod., June 1, 2003; 18(6): 1194 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Filicori, G. E. Cognigni, and W. Ciampaglia Effects of LH on oocyte yield and developmental competence Hum. Reprod., June 1, 2003; 18(6): 1357 - 1358. [Full Text] [PDF]
|
|
|
|
|
|
A. P. Cheung, S. M. Pride, B. H. Yuen, and L. Sy In-vivo ovarian androgen responses to recombinant FSH with and without recombinant LH in polycystic ovarian syndrome Hum. Reprod., October 1, 2002; 17(10): 2540 - 2547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Humaidan, L. Bungum, M. Bungum, and C.Y. Andersen Ovarian response and pregnancy outcome related to mid-follicular LH levels in women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH stimulation Hum. Reprod., August 1, 2002; 17(8): 2016 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Filicori, G. E. Cognigni, C. Tabarelli, P. Pocognoli, S. Taraborrelli, D. Spettoli, and W. Ciampaglia Stimulation and Growth of Antral Ovarian Follicles by Selective LH Activity Administration in Women J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1156 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Balasch The potential value of mid-follicular phase LH Hum. Reprod., February 1, 2002; 17(2): 518 - 520. [Full Text] [PDF]
|
|
|
|
|
|
M. Filicori The potential value of mid-follicular phase LH Hum. Reprod., February 1, 2002; 17(2): 517 - 520. [Full Text] [PDF]
|
|
|
|
 |
|
 V. Garcia-Campayo and I. Boime Independent Activities of FSH and LH Structurally Confined in a Single Polypeptide: Selective Modification of the Relative Potencies of the Hormones Endocrinology, December 1, 2001; 142(12): 5203 - 5211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Burgues The effectiveness and safety of recombinant human LH to support follicular development induced by recombinant human FSH in WHO group I anovulation: evidence from a multicentre study in Spain Hum. Reprod., December 1, 2001; 16(12): 2525 - 2532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Bath, R. A. Anderson, H. O.D. Critchley, C. J.H. Kelnar, and W.H. B. Wallace Hypothalamic-pituitary-ovarian dysfunction after prepubertal chemotherapy and cranial irradiation for acute leukaemia Hum. Reprod., September 1, 2001; 16(9): 1838 - 1844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. De Placido, A. Mollo, C. Alviggi, I. Strina, M. T. Varricchio, A. Ranieri, N. Colacurci, A. Tolino, and M. Wilding Rescue of IVF cycles by HMG in pituitary down-regulated normogonadotrophic young women characterized by a poor initial response to recombinant FSH Hum. Reprod., September 1, 2001; 16(9): 1875 - 1879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Welt, Z. A. Smith, D. K. Pauler, and J. E. Hall Differential Regulation of Inhibin A and Inhibin B by Luteinizing Hormone, Follicle-Stimulating Hormone, and Stage of Follicle Development J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2531 - 2537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
The European Recombinant LH Study Group Human Recombinant Luteinizing Hormone Is as Effective as, But Safer Than, Urinary Human Chorionic Gonadotropin in Inducing Final Follicular Maturation and Ovulation in in Vitro Fertilization Procedures: Results of a Multicenter Double-Blind Study J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2607 - 2618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Filicori and G. E. Cognigni Roles and Novel Regimens of Luteinizing Hormone and Follicle-Stimulating Hormone in Ovulation Induction J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1437 - 1441. [Abstract] [Full Text]
|
|
|
|
|
|
M. Filicori, G. L. Schattman, D. Levy, and J. Navarro LH and ovulation induction Hum. Reprod., April 1, 2001; 16(4): 803 - 804. [Full Text] [PDF]
|
|
|
|
|
|
M. Filicori, G. E. Cognigni, S. Taraborrelli, D. Spettoli, W. Ciampaglia, C. Tabarelli de Fatis, P. Pocognoli, B. Cantelli, and S. Boschi Luteinzing Hormone Activity in Menotropins Optimizes Folliculogenesis and Treatment in Controlled Ovarian Stimulation J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 337 - 343. [Abstract] [Full Text]
|
|
|
|
|
|
D. P. Levy, J. M. Navarro, G. L. Schattman, O. K. Davis, and Z. Rosenwaks The role of LH in ovarian stimulation: Exogenous LH: let's design the future Hum. Reprod., November 1, 2000; 15(11): 2258 - 2265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Fleming, P. Rehka, N. Deshpande, M.E. Jamieson, R.W.S. Yates, and H. Lyall Suppression of LH during ovarian stimulation: effects differ in cycles stimulated with purified urinary FSH and recombinant FSH Hum. Reprod., July 1, 2000; 15(7): 1440 - 1445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Filicori, G. E. Cognigni, S. Taraborrelli, D. Spettoli, W. Ciampaglia, C. Tabarelli de Fatis, and P. Pocognoli Luteinizing Hormone Activity Supplementation Enhances Follicle-Stimulating Hormone Efficacy and Improves Ovulation Induction Outcome J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2659 - 2663. [Abstract] [Full Text]
|
|
|
|
|
|
A. H. Balen, C. J. Hayden, and A. J. Rutherford Clinical efficacy of recombinant gonadotrophins Hum. Reprod., June 1, 1999; 14(6): 1411 - 1417. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
