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Loss of the Expression and Localization of Inhibin -Subunit in High Grade Prostate Cancer¹

Institute of Reproduction and Development (S.L.M., M.G.R., G.P.R.) and Prince Henry’s Institute of Medical Research (D.M.R.), Monash Medical Center, Clayton, Victoria 3168; and Melbourne Pathology (J.S.P.), Collingwood, Victoria 3066, Australia

Address all correspondence and requests for reprints to: Dr. G. P. Risbridger, Institute of Reproduction and Development, Monash University, Level 3, Block E, Monash Medical Center, 246 Clayton Road, Clayton, Victoria 3168, Australia. E-mail: gail.risbridger{at}med.monash.edu.au

Serum inhibin levels are elevated in postmenopausal women with granulosa and mucinous epithelial tumors of the ovary. In contrast, functional deletion of the inhibin gene in male and female mice results in the development of primary gonadal granulosa/Sertoli cell tumors. The aim of this study was to determine whether inhibin -subunit gene and protein expression are altered in prostate cancer. Messenger ribonucleic acid expression was studied by in situ hybridization, and protein localization was studied by immunohistochemistry. Inhibin -subunit messenger ribonucleic acid expression and protein localization were observed in the epithelium of tissues from men with benign prostatic hyperplasia, in regions of basal cell hyperplasia, and in nonmalignant regions of tissue from men with high grade prostate cancer. In the malignant regions of tissue from men with high grade prostate cancer, the expression of the inhibin -subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. These results demonstrate that in contrast to ovarian granulosa cell tumors, inhibin gene expression is down-regulated in poorly differentiated prostate cancer.

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