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Association Between Insulin-Like Growth Factor I and Bone Mineral Density in Older Women and Men: The Framingham Heart Study¹

Epidemiology, Demography, and Biometry Program (J.A.L., M.V., T.H.), National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892; St. Joseph Hospital (C.J.R.), Bangor, Maine 04401; Hebrew Rehabilitation Center for Aged (M.T.H., D.P.K.), Research and Training Institute, and Harvard Medical School Division on Aging, Boston, Massachusetts 02131; National Heart, Lung and Blood Institute’s Framingham Heart Study (P.W.F.W.), National Institutes of Health, Bethesda, Maryland 20892

Address all correspondence and requests for reprints to: Jean A. Langlois, Division of Acute Care, Rehabilitation Research, and Disability Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Highway, NE (MS F-41), Atlanta, Georgia 30341-3724. E-mail: JAL7{at}CDC.GOV

Few studies of the GH axis and bone have focused specifically on elderly people. The objective of this study was to determine the association between insulin-like growth factor I (IGF-I) and bone mineral density (BMD) in 425 women and 257 men aged 72–94 who participated in the Framingham Osteoporosis Study component of the Framingham Heart Study in 1992–1993. Serum IGF-I level was determined by RIA. BMD at three femoral sites and the lumbar spine was determined by dual x-ray absorptiometry, and at the radius by single-photon absorptiometry. IGF-I level was positively associated with BMD at all five sites (Ward’s area, femoral neck, trochanter, radius, and lumbar spine) in women after adjustment for weight loss and other factors (P 0.01) and protein intake in a subset of participants (0.006 < P < 0.07). A threshold effect of higher BMD was evident at each of the 3 femoral sites and the spine (P < 0.03) but not at the radius for women in the highest quintile of IGF-I (179 g/liter) vs. those in the lowest four quintiles. IGF-I was not significantly associated with BMD in men. These results indicate that higher IGF-I levels are associated with greater BMD in very old women, and suggest that future clinical trials employing GH may have a role in the development of treatments for older women with osteoporosis.

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