help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Suzuki, T.
Right arrow Articles by Krozowski, Z. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Suzuki, T.
Right arrow Articles by Krozowski, Z. S.
The Journal of Clinical Endocrinology & Metabolism Vol. 83, No. 11 4022-4025
Copyright © 1998 by The Endocrine Society

Original Studies

11ß-Hydroxysteroid Dehydrogenase Type 2 in Human Lung: Possible Regulator of Mineralocorticoid Action

Takashi Suzuki, Hironobu Sasano, Satoshi Suzuki, Gen Hirasawa, Junji Takeyama, Yasunari Muramatsu, Fumiko Date, Hiroshi Nagura and Zygmunt S. Krozowski

Department of Pathology, Tohoku University School of Medicine (T.S., H.S., G.H., J.T., Y.M., F.D., H.N.), and the Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University (S.S.), Sendai 980-8575, Japan; and the Laboratory of Molecular Hypertension, Baker Medical Research Institute (Z.S.K.), Melbourne, Australia

Address all correspondence and requests for reprints to: Takashi Suzuki M.D., Department of Pathology, Tohoku University School of Medicine, 2–1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan. E-mail: t-suzuki{at}patholo2.med.tohoku.ac.jp

11ß-Hydroxysteroid dehydrogenase type 2 (11ßHSD2) catalyzes the conversion of cortisol to biologically inactive cortisone and is thought to confer specificity on mineralocorticoid receptors (MR). Cortisol is a prerequisite for surfactant synthesis and fetal lung maturation. Recently, expression of 11ßHSD2 was demonstrated in human fetal lung, but its localization and possible biological roles remain unknown. Therefore, in this study, we examined immunohistochemical localization of 11ßHSD2, MR, and glucocorticoid receptor (GR) in nonpathological human lungs from fetus to adult (8 weeks gestation to 55 yr of age; n = 40) retrieved from pathology files. Both 11ßHSD2 and MR immunoreactivities were detected in airway epithelia, from bronchiole to trachea and in fetal and neonatal ciliated collecting duct cells of tracheal and bronchial glands, but were undetectable in alveoli. On the other hand, GR was detected in all cell types. These results indicate that 11ßHSD2 colocalizes with MR in human airway epithelia and suggest that 11ßHSD2 play an important role in pulmonary mineralocorticoid activity such as sodium and fluid transport.




This article has been cited by other articles:


Home page
 Eur J EndocrinolHome page
M. Schroth, C. Plank, M. Rauh, H.-G. Dorr, W. Rascher, and J. Dotsch
Pediatric renal allograft transplantation does not normalize the increased cortisol/cortisone ratios of chronic renal failure.
Eur. J. Endocrinol., April 1, 2006; 154(4): 555 - 561.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
M. Keller-Wood, C. E. Wood, Y. Hua, and D. Zhang
Mineralocorticoid Receptor Expression in Late-Gestation Ovine Fetal Lung
Reproductive Sciences, February 1, 2005; 12(2): 84 - 91.
[Abstract] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. J. Cole, N. M. Solomon, R. Van Driel, J. A. Monk, D. Bird, S. J. Richardson, R. J. Dilley, and S. B. Hooper
Altered Epithelial Cell Proportions in the Fetal Lung of Glucocorticoid Receptor Null Mice
Am. J. Respir. Cell Mol. Biol., May 1, 2004; 30(5): 613 - 619.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
M. A. Miller, S. J. Kottler, J. A. Ramos-Vara, P. J. Johnson, V. K. Ganjam, and T. J. Evans
3-Methylindole Induces Transient Olfactory Mucosal Injuryin Ponies
Vet. Pathol., July 1, 2003; 40(4): 363 - 370.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Suzuki, K. Koyama, A. Darnel, H. Ishibashi, S. Kobayashi, H. Kubo, T. Suzuki, H. Sasano, and Z. S. Krozowski
Dexamethasone Upregulates 11{beta}-Hydroxysteroid Dehydrogenase Type 2 in BEAS-2B Cells
Am. J. Respir. Crit. Care Med., May 1, 2003; 167(9): 1244 - 1249.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Mune, H. Morita, T. Suzuki, Y. Takahashi, Y. Isomura, T. Tanahashi, H. Daido, N. Yamakita, T. Deguchi, H. Sasano, et al.
Role of Local 11{beta}-Hydroxysteroid Dehydrogenase Type 2 Expression in Determining the Phenotype of Adrenal Adenomas
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 864 - 870.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. J. Pepe, P. L. Ballard, and E. D. Albrecht
Fetal Lung Maturation in Estrogen-Deprived Baboons
J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 471 - 477.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Diederich, E. Eigendorff, P. Burkhardt, M. Quinkler, C. Bumke-Vogt, M. Rochel, D. Seidelmann, P. Esperling, W. Oelkers, and V. Bahr
11{beta}-Hydroxysteroid Dehydrogenase Types 1 and 2: An Important Pharmacokinetic Determinant for the Activity of Synthetic Mineralo- and Glucocorticoids
J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5695 - 5701.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. A. Matthay, H. G. Folkesson, and C. Clerici
Lung Epithelial Fluid Transport and the Resolution of Pulmonary Edema
Physiol Rev, July 1, 2002; 82(3): 569 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. E. ORSIDA, Z. S. KROZOWSKI, and E. H. WALTERS
Clinical Relevance of Airway 11beta -Hydroxysteroid Dehydrogenase Type II Enzyme in Asthma
Am. J. Respir. Crit. Care Med., April 1, 2002; 165(7): 1010 - 1014.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Le Menuet, R. Isnard, M. Bichara, S. Viengchareun, M. Muffat-Joly, F. Walker, M.-C. Zennaro, and M. Lombes
Alteration of Cardiac and Renal Functions in Transgenic Mice Overexpressing Human Mineralocorticoid Receptor
J. Biol. Chem., October 12, 2001; 276(42): 38911 - 38920.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G.A.W. Rook, G. Seah, and A. Ustianowski
M. tuberculosis: immunology and vaccination
Eur. Respir. J., March 1, 2001; 17(3): 537 - 557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. W. BAKER, B. R. WALKER, R. J. SHAW, J. W. HONOUR, D. S. JESSOP, S. L. LIGHTMAN, A. ZUMLA, and G. A. W. ROOK
Increased Cortisol . Cortisone Ratio in Acute Pulmonary Tuberculosis
Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1641 - 1647.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Hirasawa, H. Sasano, T. Suzuki, J. Takeyama, Y. Muramatu, K. Fukushima, N. Hiwatashi, T. Toyota, H. Nagura, and Z. S. Krozowski
11{beta}-Hydroxysteroid Dehydrogenase Type 2 and Mineralocorticoid Receptor in Human Fetal Development
J. Clin. Endocrinol. Metab., April 1, 1999; 84(4): 1453 - 1458.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1998 by The Endocrine Society