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Procollagen Propeptide and Pyridinium Cross-Links as Markers of Type I Collagen Turnover: Sex- and Age-Related Changes in Healthy Children¹

CNRS URA 583, Université Paris V, Hôpital St. Vincent de Paul (M.Z, M.G.), 75014 Paris; France Laboratoire d’Explorations Fonctionnelles, Hôpital Necker-Enfants Malades (J.C.S., C.K.), 75015 Paris; and Centre des Bilans de Santé de l’Enfant de Paris (C.R.), 75011 Paris, France

Address all correspondence and requests for reprints to: Dr. Michèle Garabédian, CNRS URA 583, Hôpital Saint Vincent de Paul, 82 avenue Denfert Rochereau, 75014 Paris, France.

The correlations among age, gender, body size parameters, and type I collagen metabolism were evaluated in 183 healthy infants, aged 8.5–27.5 months. Collagen formation was assessed by measuring serum type I collagen carboxy-terminal propeptide, and degradation was determined by urinary pyridinoline and deoxypyridinoline (measured by high performance liquid chromatography) and cross-linked N- and C-terminal telopeptides of type I collagen (measured by NTx and CrossLaps assays). A new RIA specific for deoxypyridinoline was also evaluated. The results provide reference values at 10 months and 2 yr of age, including cross-linked C-terminal telopeptides (1492 ± 685 and 1510 ± 446 in boys; 1705 ± 612 and 1849 ± 611 µg/mmol creatinine in girls; mean ± 1 SD). There was a good correlation between the high performance liquid chromatography and RIA data for deoxypyridinoline, showing that the RIA method is suitable for use in healthy children. Some correlations were found among peptide-bound cross-links, serum type I collagen carboxy-terminal propeptide, and the anthropometric parameters, suggesting that these peptides reflect bone resorption and also overall body type I collagen. Finally, there were age- and sex-related differences in the urinary excretion of the collagen degradation markers, suggesting that, unlike boys, girls maintain a high degree of collagen degradation up to the age of 24 months despite a decrease in their rate of collagen formation.

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