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The Journal of Clinical Endocrinology & Metabolism Vol. 82, No. 9 2966-2970
Copyright © 1997 by The Endocrine Society

Original Studies

Association between Vitamin D Receptor Gene Polymorphism and Sex-Dependent Growth during the First Two Years of Life1

Francoise Suarez, Fatiha Zeghoud, Claude Rossignol, Odile Walrant and Michèle Garabédian

CNRS Unité de Recherche Associée 583 (F.S., F.Z., O.W., M.G.) - Université Paris V, Hôpital Saint Vincent de Paul, 75014 Paris, France; and Centre des Bilans de Santé de l’Enfant (C.R.), CPAM de Paris, 75011 Paris, France

Address all correspondence and requests for reprints to: M. Garabédian, CNRS URA 583, Hôpital Saint Vincent de Paul, 82 Avenue Denfert Rochereau, 75014 Paris, France.

An association between vitamin D receptor (VDR) gene polymorphisms and bone mass variance has been observed in adult populations. To analyze possible association between VDR genotype and growth, we studied 589 healthy infants who were homogeneous for age, diet, and vitamin D status. The Bsm I, TaqI, and ApaI alleles’ frequencies and genotypes were similar to those reported for Caucasian populations. Variations in Bsm I polymorphism were not associated with calcium intakes nor with serum levels of calcium, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or alkaline phosphatase activity. But, they were associated with differences in body size. At 2 yr, homozygote BB (BsmI site absent) girls had higher length, weight and body surface area, and inversely, BB boys had lower weight, body mass index and body surface area, than their respective bb counterparts. As a result, gender-related differences were observed in Bb and bb, but not in BB populations. This VDR genotypic effect was observed also at birth and at 10 months in the longitudinal analysis of 145 selected full-term babies homozygous for the Bsm I polymorphism. These findings provide support for the hypothesis that VDR genotype influences intrauterine and early postnatal growth, directly or via interactions with gender-related growth regulators.




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