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The Journal of Clinical Endocrinology & Metabolism Vol. 82, No. 8 2677-2680
Copyright © 1997 by The Endocrine Society

Experimental Studies

Influence of Circulating Epinephrine and Norepinephrine on Insulin-Like Growth Factor Binding Protein-1 in Humans

Eva Fernqvist-Forbes, Agneta Hilding, Karin Ekberg and Kerstin Brismar

Department of Surgical Sciences, Division of Clinical Physiology (E.F-F., K.E.); and Department of Molecular Medicine, Endocrine and Diabetes Unit (A.H., K.B.) Karolinska Hospital, Stockholm, Sweden

Address all correspondence and requests for reprints to: Eva Fernqvist-Forbes, Division of Clinical Physiology, Karolinska Hospital, S-171 76 Stockholm, Sweden.

The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations. Healthy men received 0.3 nmol·kg·min Epi iv (n = 6), 0.5 nmol·kg·min Norepi iv (n = 7), or saline (n = 5) during 30 min. Arterial blood samples were obtained before, during, and 120 min after infusion. During the catecholamine infusion arterial Epi and Norepi plasma concentrations reached 6.35 ± 0.53 and 15.65 ± 2.71 nmol/L, respectively, which resulted in significant increases in glucose concentrations. When Epi was infused, IGFBP-1 increased from 45 ± 6 µg/L to 76 ± 10 µg/L (P < 0.05) 60 min after the infusion. Epi was also followed by increases in insulin, C-peptide, and glucagon. Norepi resulted in a slight increase in circulating IGFBP-1 (43 ± 6 to 54 ± 8 nmol/L, NS). The findings suggest that Epi, at plasma concentrations similar to those reached during physical stress, stimulates the production of IGFBP-1 in humans.




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Copyright © 1997 by The Endocrine Society