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The Journal of Clinical Endocrinology & Metabolism Vol. 82, No. 8 2396-2402
Copyright © 1997 by The Endocrine Society

Reproductive Endocrinology

Marked Decline in Serum Concentrations of Adrenal C19 Sex Steroid Precursors and Conjugated Androgen Metabolites During Aging

Fernand Labrie, Alain Bélanger, Lionel Cusan, José-Luis Gomez and Bernard Candas

Laboratory of Molecular Endocrinology, CHUL Research Center, Le Centre Hospitalier Universitaire de Québec, and Laval University, Québec, G1V 4G2, Canada

Address all correspondence and requests for reprints to: Fernand Labrie, Laboratory of Molecular Endocrinology, CHUL Research Center, 2705 Laurier Boulevard, Québec (Québec), G1V 4G2, Canada.

The present data show a dramatic decline in the circulating levels of dehydroepiandrosterone (DHEA), DHEA-sulfate (DHEA-S), androst-5-ene-3ß,17ß-diol (5-diol), 5-diol-sulfate, 5-diol-fatty acid esters, and androstenedione in both men and women between the ages of 20–80 yr. In the 50- to 60-yr-old group, serum DHEA decreased by 74% and 70% from its peak values in 20- to 30-yr-old men and women, respectively. The serum concentrations of the conjugated metabolites of dihydrotestosterone (DHT), namely androsterone (ADT)-G, androstane-3{alpha},17ß-diol (3{alpha}-diol-G), androstane-3ß,17ß-diol (3ß-diol-G), and ADT-sulfate are the most reliable parameters of the total androgen pool in both men and women, whereas serum testosterone and DHT can be used as markers of testicular secretion in men and interstitial ovarian secretion in women. The serum concentration of these various conjugated androgen metabolites decreased by 40.8% to 72.8% between the 20- to 30-yr-old and 70- to 80-yr-old age groups in men and women, respectively, thus suggesting a parallel decrease in the total androgen pool with age. As estimated by measurement of the circulating levels of these conjugated metabolites of DHT, it is noteworthy that women produce approximately 66% of the total androgens found in men. In women, most of these androgens originate from the transformation of DHEA and DHEA-S into testosterone and DHT in peripheral intracrine tissues, whereas in men the testes and DHEA and DHEA-S provide approximately equal amounts of androgens at the age of 50–60 yr. An additional potentially highly significant observation is that the majority of the marked decline in circulating adrenal C19 steroids and their resulting androgen metabolites takes place between the age groups of 20- to 30-yr olds and 50- to 60-yr-olds, with smaller changes are observed after the age of 60 yr.




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D. A. Sullivan, B. D. Sullivan, M. D. Ullman, E. M. Rocha, K. L. Krenzer, J. M. Cermak, I. Toda, M. G. Doane, J. E. Evans, and L. A. Wickham
Androgen Influence on the Meibomian Gland
Invest. Ophthalmol. Vis. Sci., November 1, 2000; 41(12): 3732 - 3742.
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G. A. Laughlin and E. Barrett-Connor
Sexual Dimorphism in the Influence of Advanced Aging on Adrenal Hormone Levels: The Rancho Bernardo Study
J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3561 - 3568.
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S. Legrain, C. Massien, N. Lahlou, M. Roger, B. Debuire, B. Diquet, G. Chatellier, M. Azizi, V. Faucounau, H. Porchet, et al.
Dehydroepiandrosterone Replacement Administration: Pharmacokinetic and Pharmacodynamic Studies in Healthy Elderly Subjects
J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3208 - 3217.
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E.-E. Baulieu, G. Thomas, S. Legrain, N. Lahlou, M. Roger, B. Debuire, V. Faucounau, L. Girard, M.-P. Hervy, F. Latour, et al.
Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: Contribution of the DHEAge Study to a sociobiomedical issue
PNAS, April 11, 2000; 97(8): 4279 - 4284.
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C. Couillard, J. Gagnon, J. Bergeron, A. S. Leon, D. C. Rao, J. S. Skinner, J. H. Wilmore, J.-P. Després, and C. Bouchard
Contribution of Body Fatness and Adipose Tissue Distribution to the Age Variation in Plasma Steroid Hormone Concentrations in Men: The HERITAGE Family Study
J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 1026 - 1031.
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G. A. Laughlin, E. Barrett-Connor, D. Kritz-Silverstein, and D. von Mühlen
Hysterectomy, Oophorectomy, and Endogenous Sex Hormone Levels in Older Women: The Rancho Bernardo Study
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 645 - 651.
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C. R. Parker Jr., S. M. Slayden, R. Azziz, S. L. Crabbe, G. A. Hines, L. R. Boots, and S. Bae
Effects of Aging on Adrenal Function in the Human: Responsiveness and Sensitivity of Adrenal Androgens and Cortisol to Adrenocorticotropin in Premenopausal and Postmenopausal Women
J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 48 - 54.
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E. M Rocha, L A. Wickham, L. A da Silveira, K. L Krenzer, F.-S. Yu, I. Toda, B. D Sullivan, and D. A Sullivan
Identification of androgen receptor protein and 5alpha -reductase mRNA in human ocular tissues
Br J Ophthalmol, January 1, 2000; 84(1): 76 - 84.
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G. W. Wolkersdörfer, T. Lohmann, C. Marx, S. Schröder, R. Pfeiffer, H.-D. Stahl, W. A. Scherbaum, G. P. Chrousos, and S. R. Bornstein
Lymphocytes Stimulate Dehydroepiandrosterone Production through Direct Cellular Contact with Adrenal Zona Reticularis Cells: A Novel Mechanism of Immune-Endocrine Interaction
J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 4220 - 4227.
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C. Albert, M. Vallée, G. Beaudry, A. Bélanger, and D. W. Hum
The Monkey and Human Uridine Diphosphate-Glucuronosyltransferase UGT1A9, Expressed in Steroid Target Tissues, Are Estrogen-Conjugating Enzymes
Endocrinology, July 1, 1999; 140(7): 3292 - 3302.
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M. Fossel
Telomerase and the Aging Cell: Implications for Human Health
JAMA, June 3, 1998; 279(21): 1732 - 1735.
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F. Labrie, P. Diamond, L. Cusan, J.-L. Gomez, A. Belanger, and B. Candas
Effect of 12-Month Dehydroepiandrosterone Replacement Therapy on Bone, Vagina, and Endometrium in Postmenopausal Women
J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3498 - 3505.
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