help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sih, R.
Right arrow Articles by Ross, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sih, R.
Right arrow Articles by Ross, C.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*TESTOSTERONE
The Journal of Clinical Endocrinology & Metabolism Vol. 82, No. 6 1661-1667
Copyright © 1997 by The Endocrine Society

Reproductive Endocrinology

Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial

Rahmawati Sih, John E. Morley, Fran E. Kaiser, Horace M. Perry, III, Ping Patrick and Candie Ross

Division of Geriatric Medicine, St. Louis University Health Sciences Center (R.S., J.E.M., F.E.K., H.M.P., P.P., C.R.), St. Louis, Missouri 63104; and Geriatric Research and Education Clinical Center, St. Louis-Veterans Affairs Medical Center (R.S., J.E.M., H.M.P.), St. Louis, Missouri 63125

Address all correspondence and requests for reprints to: Rahmawati Sih, Division of Geriatric Medicine, St. Louis University Health Sciences Center, 1402 South Grand Boulevard, Room M238, St. Louis, Missouri 63104.

A decline in testicular function is recognized as a common occurrence in older men. However data are sparse regarding the effects of hypogonadism on age-associated physical and cognitive declines. This study was undertaken to examine the year-long effects of testosterone administration in this patient population.

Fifteen hypogonadal men (mean age 68 ± 6 yr) were randomly assigned to receive a placebo, and 17 hypogonadal men (mean age 65 ± 7 yr) were randomly assigned to receive testosterone. Hypogonadism was defined as a bioavailable testosterone <60 ng/dL. The men received injections of placebo or 200 mg testosterone cypionate biweekly for 12 months. The main outcomes measured included grip strength, hemoglobin, prostate-specific antigen, leptin, and memory.

Testosterone improved bilateral grip strength (P < 0.05 by ANOVA) and increased hemoglobin (P < 0.001 by ANOVA). The men assigned to testosterone had greater decreases in leptin than those assigned to the control group (mean ± SEM: -2.0 ± 0.9 ng/dL vs. 0.8 ± 0.7 ng/dL; P < 0.02). There were no significant changes in prostate-specific antigen or memory. Three subjects receiving placebo and seven subjects receiving testosterone withdrew from the study. Three of those seven withdrew because of an abnormal elevation in hematocrit.

Testosterone supplementation improved strength, increased hemoglobin, and lowered leptin levels in older hypogonadal men. Testosterone may have a role in the treatment of frailty in males with hypogonadism; however, older men receiving testosterone must be carefully monitored because of its potential risks.




This article has been cited by other articles:


Home page
 J PsychopharmacolHome page
M Ebinger, C Sievers, D Ivan, H. Schneider, and G. Stalla
Is there a neuroendocrinological rationale for testosterone as a therapeutic option in depression?
J Psychopharmacol, September 1, 2009; 23(7): 841 - 853.
[Abstract] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. R. Sattler, C. Castaneda-Sceppa, E. F. Binder, E. T. Schroeder, Y. Wang, S. Bhasin, M. Kawakubo, Y. Stewart, K. E. Yarasheski, J. Ulloor, et al.
Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men
J. Clin. Endocrinol. Metab., June 1, 2009; 94(6): 1991 - 2001.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
J.-J. Legros, E. J H Meuleman, J. M H Elbers, T B P. Geurts, M. J G H Kaspers, P. M G Bouloux, and for the Study 43203 Investigators
Oral testosterone replacement in symptomatic late-onset hypogonadism: effects on rating scales and general safety in a randomized, placebo-controlled study
Eur. J. Endocrinol., May 1, 2009; 160(5): 821 - 831.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Singh, S. Bhasin, M. Braga, J. N. Artaza, S. Pervin, W. E. Taylor, V. Krishnan, S. K. Sinha, T. B. Rajavashisth, and R. Jasuja
Regulation of Myogenic Differentiation by Androgens: Cross Talk between Androgen Receptor/ {beta}-Catenin and Follistatin/Transforming Growth Factor-{beta} Signaling Pathways
Endocrinology, March 1, 2009; 150(3): 1259 - 1268.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
L.-W. Chu, S. Tam, A. W. C. Kung, T.-P. Lam, A. Lee, R. L. C. Wong, S. Lo, S. Fan, C.-P. Chung, J. E. Morley, et al.
A Short Version of the ADAM Questionnaire for Androgen Deficiency in Chinese Men
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2008; 63(4): 426 - 431.
[Abstract] [Full Text] [PDF]

Home page
 AMERICAN JOURNAL OF LIFESTYLE MEDICINEHome page
M. Wald, M. Miner, and A. D. Seftel
State of the Art Reviews: Male Menopause: Fact or Fiction?
American Journal of Lifestyle Medicine, April 1, 2008; 2(2): 132 - 141.
[Abstract] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. D. Coviello, B. Kaplan, K. M. Lakshman, T. Chen, A. B. Singh, and S. Bhasin
Effects of Graded Doses of Testosterone on Erythropoiesis in Healthy Young and Older Men
J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 914 - 919.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. H. Emmelot-Vonk, H. J. J. Verhaar, H. R. Nakhai Pour, A. Aleman, T. M. T. W. Lock, J. L. H. R. Bosch, D. E. Grobbee, and Y. T. van der Schouw
Effect of Testosterone Supplementation on Functional Mobility, Cognition, and Other Parameters in Older Men: A Randomized Controlled Trial
JAMA, January 2, 2008; 299(1): 39 - 52.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
F. Giton, S. Urien, C. Born, J. Tichet, J. Guechot, J. Callebert, F. Bronsard, J. P. Raynaud, and J. Fiet
Determination of Bioavailable Testosterone [Non Sex Hormone Binding Globulin (SHBG)-Bound Testosterone] in a Population of Healthy French Men: Influence of Androstenediol on Testosterone Binding to SHBG
Clin. Chem., December 1, 2007; 53(12): 2160 - 2168.
[Abstract] [Full Text] [PDF]

Home page
 cfpHome page
A. Katz, A. Katz, and C. Burchill
Androgen therapy: Testing before prescribing and monitoring during therapy
Can Fam Physician, November 1, 2007; 53(11): 1936 - 1942.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. M. Maki, M. Ernst, E. D. London, K. L. Mordecai, P. Perschler, S. C. Durso, J. Brandt, A. Dobs, and S. M. Resnick
Intramuscular Testosterone Treatment in Elderly Men: Evidence of Memory Decline and Altered Brain Function
J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4107 - 4114.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
C. Vaughan, F. C. Goldstein, and J. L. Tenover
Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone
J Androl, November 1, 2007; 28(6): 875 - 882.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. E. Borst, C. F. Conover, C. S. Carter, C. M. Gregory, E. Marzetti, C. Leeuwenburgh, K. Vandenborne, and T. J. Wronski
Anabolic effects of testosterone are preserved during inhibition of 5{alpha}-reductase
Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E507 - E514.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
R. M. Haddad, C. C. Kennedy, S. M. Caples, M. J. Tracz, E. R. Bolona, K. Sideras, M. V. Uraga, P. J. Erwin, and V. M. Montori
Testosterone and Cardiovascular Risk in Men: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials
Mayo Clin. Proc., January 1, 2007; 82(1): 29 - 39.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
O. Beauchet
Testosterone and cognitive function: current clinical evidence of a relationship
Eur. J. Endocrinol., December 1, 2006; 155(6): 773 - 781.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Y. Liu, P. Y. Takahashi, P. D. Roebuck, and J. D. Veldhuis
Age or Factors Associated with Aging Attenuate Testosterone's Concentration-Dependent Enhancement of the Regularity of Luteinizing Hormone Secretion in Healthy Men
J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 4077 - 4084.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
M.-H. Gannage-Yared, S. Khalife, M. Semaan, F. Fares, S. Jambart, and G. Halaby
Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men.
Eur. J. Endocrinol., July 1, 2006; 155(1): 167 - 176.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J J Corrales, M Almeida, R Burgo, M T Mories, J M Miralles, and A Orfao
Androgen-replacement therapy depresses the ex vivo production of inflammatory cytokines by circulating antigen-presenting cells in aging type-2 diabetic men with partial androgen deficiency.
J. Endocrinol., June 1, 2006; 189(3): 595 - 604.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Bhasin, G. R. Cunningham, F. J. Hayes, A. M. Matsumoto, P. J. Snyder, R. S. Swerdloff, and V. M. Montori
Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline
J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 1995 - 2010.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. J. Tracz, K. Sideras, E. R. Bolona, R. M. Haddad, C. C. Kennedy, M. V. Uraga, S. M. Caples, P. J. Erwin, and V. M. Montori
Testosterone Use in Men and Its Effects on Bone Health. A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials
J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2011 - 2016.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
V. Di Francesco, M. Zamboni, E. Zoico, G. Mazzali, A. Dioli, F. Omizzolo, L. Bissoli, F. Fantin, P. Rizzotti, S. B Solerte, et al.
Unbalanced serum leptin and ghrelin dynamics prolong postprandial satiety and inhibit hunger in healthy elderly: another reason for the "anorexia of aging"
Am. J. Clinical Nutrition, May 1, 2006; 83(5): 1149 - 1152.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. E Morley, D. R Thomas, and M.-M. G Wilson
Cachexia: pathophysiology and clinical relevance.
Am. J. Clinical Nutrition, April 1, 2006; 83(4): 735 - 743.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
F. Giton, J. Fiet, J. Guechot, F. Ibrahim, F. Bronsard, D. Chopin, and J.-P. Raynaud
Serum Bioavailable Testosterone: Assayed or Calculated?
Clin. Chem., March 1, 2006; 52(3): 474 - 481.
[Abstract] [Full Text] [PDF]

Home page
 Nutr Clin PractHome page
D. R. Thomas
Guidelines for the Use of Orexigenic Drugs in Long-Term Care
Nutr Clin Pract, February 1, 2006; 21(1): 82 - 87.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. B. O'Donnell, T. G. Travison, S. S. Harris, J. L. Tenover, and J. B. McKinlay
Testosterone, Dehydroepiandrosterone, and Physical Performance in Older Men: Results from the Massachusetts Male Aging Study
J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 425 - 431.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Y. Liu, S. M. Pincus, P. Y. Takahashi, P. D. Roebuck, A. Iranmanesh, D. M. Keenan, and J. D. Veldhuis
Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade
Am J Physiol Endocrinol Metab, January 1, 2006; 290(1): E34 - E41.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
E. T. Schroeder, A. F. Vallejo, L. Zheng, Y. Stewart, C. Flores, S. Nakao, C. Martinez, and F. R. Sattler
Six-Week Improvements in Muscle Mass and Strength During Androgen Therapy in Older Men
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2005; 60(12): 1586 - 1592.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. N. Lessov-Schlaggar, T. Reed, G. E. Swan, R. E. Krasnow, C. DeCarli, R. Marcus, L. Holloway, P. A. Wolf, and D. Carmelli
Association of sex steroid hormones with brain morphology and cognition in healthy elderly men
Neurology, November 22, 2005; 65(10): 1591 - 1596.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
O. M. Calof, A. B. Singh, M. L. Lee, A. M. Kenny, R. J. Urban, J. L. Tenover, and S. Bhasin
Adverse Events Associated With Testosterone Replacement in Middle-Aged and Older Men: A Meta-Analysis of Randomized, Placebo-Controlled Trials
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2005; 60(11): 1451 - 1457.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. M. Kaufman and A. Vermeulen
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Endocr. Rev., October 1, 2005; 26(6): 833 - 876.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. B. Gray, A. B. Singh, L. J. Woodhouse, T. W. Storer, R. Casaburi, J. Dzekov, C. Dzekov, I. Sinha-Hikim, and S. Bhasin
Dose-Dependent Effects of Testosterone on Sexual Function, Mood, and Visuospatial Cognition in Older Men
J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 3838 - 3846.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
J. Chen, J. Kim, and J. T. Dalton
Discovery and Therapeutic Promise of Selective Androgen Receptor Modulators
Mol. Interv., June 1, 2005; 5(3): 173 - 188.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
W. Fan, T. Yanase, M. Nomura, T. Okabe, K. Goto, T. Sato, H. Kawano, S. Kato, and H. Nawata
Androgen Receptor Null Male Mice Develop Late-Onset Obesity Caused by Decreased Energy Expenditure and Lipolytic Activity but Show Normal Insulin Sensitivity With High Adiponectin Secretion
Diabetes, April 1, 2005; 54(4): 1000 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
C. A. Orengo, L. Fullerton, and M. E. Kunik
Safety and Efficacy of Testosterone Gel 1% Augmentation in Depressed Men With Partial Response to Antidepressant Therapy
J Geriatr Psychiatry Neurol, March 1, 2005; 18(1): 20 - 24.
[Abstract] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
S. J. Fonda, R. Bertrand, A. O'Donnell, C. Longcope, and J. B. McKinlay
Age, Hormones, and Cognitive Functioning Among Middle-Aged and Elderly Men: Cross-Sectional Evidence From the Massachusetts Male Aging Study
J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2005; 60(3): 385 - 390.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. T. Page, J. K. Amory, F. D. Bowman, B. D. Anawalt, A. M. Matsumoto, W. J. Bremner, and J. L. Tenover
Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T
J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1502 - 1510.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Bhasin, L. Woodhouse, R. Casaburi, A. B. Singh, R. P. Mac, M. Lee, K. E. Yarasheski, I. Sinha-Hikim, C. Dzekov, J. Dzekov, et al.
Older Men Are as Responsive as Young Men to the Anabolic Effects of Graded Doses of Testosterone on the Skeletal Muscle
J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 678 - 688.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. M. Cherrier, A. M. Matsumoto, J. K. Amory, S. Ahmed, W. Bremner, E. R. Peskind, M. A. Raskind, M. Johnson, and S. Craft
The role of aromatization in testosterone supplementation: Effects on cognition in older men
Neurology, January 25, 2005; 64(2): 290 - 296.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. E. Borst, J. H. Lee, and C. F. Conover
Inhibition of 5{alpha}-reductase blocks prostate effects of testosterone without blocking anabolic effects
Am J Physiol Endocrinol Metab, January 1, 2005; 288(1): E222 - E227.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. N. Seidman and D. F. Klein
AA2500 Testosterone Gel Normalizes Androgen Levels in Aging Males with Improvements in Body Composition and Sexual Function
J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6358 - 6359.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Y. Liu, R. S. Swerdloff, and J. D. Veldhuis
The Rationale, Efficacy and Safety of Androgen Therapy in Older Men: Future Research and Current Practice Recommendations
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4789 - 4796.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. T. Schroeder, L. Zheng, M. D. Ong, C. Martinez, C. Flores, Y. Stewart, C. Azen, and F. R. Sattler
Effects of Androgen Therapy on Adipose Tissue and Metabolism in Older Men
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4863 - 4872.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. Vanderschueren, L. Vandenput, S. Boonen, M. K. Lindberg, R. Bouillon, and C. Ohlsson
Androgens and Bone
Endocr. Rev., June 1, 2004; 25(3): 389 - 425.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Meier, P. Y. Liu, L. P. Ly, J. de Winter-Modzelewski, M. Jimenez, D. J. Handelsman, and M. J. Seibel
Recombinant Human Chorionic Gonadotropin But Not Dihydrotestosterone Alone Stimulates Osteoblastic Collagen Synthesis in Older Men with Partial Age-Related Androgen Deficiency
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 3033 - 3041.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. E. Morley
Is the Hormonal Fountain of Youth Drying Up?
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2004; 59(5): M458 - M460.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. Z. Leder, J. L. Rohrer, S. D. Rubin, J. Gallo, and C. Longcope
Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testosterone Levels
J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1174 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
D. R. Thomas
Anemia and Quality of Life: Unrecognized and Undertreated
J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2004; 59(3): M238 - M241.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. T. Schroeder, L. Zheng, K. E. Yarasheski, D. Qian, Y. Stewart, C. Flores, C. Martinez, M. Terk, and F. R. Sattler
Treatment with oxandrolone and the durability of effects in older men
J Appl Physiol, March 1, 2004; 96(3): 1055 - 1062.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. G. Ryall, D. R. Plant, P. Gregorevic, M. N. Sillence, and G. S. Lynch
{beta}2-Agonist administration reverses muscle wasting and improves muscle function in aged rats
J. Physiol., February 15, 2004; 555(1): 175 - 188.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. J. Woodhouse, N. Gupta, M. Bhasin, A. B. Singh, R. Ross, J. Phillips, and S. Bhasin
Dose-Dependent Effects of Testosterone on Regional Adipose Tissue Distribution in Healthy Young Men
J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 718 - 726.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. E. Morley
The Metabolic Syndrome and Aging
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2004; 59(2): M139 - 142.
[Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
M. M. Shores, K. L. Sloan, A. M. Matsumoto, V. M. Moceri, B. Felker, and D. R. Kivlahan
Increased Incidence of Diagnosed Depressive Illness in Hypogonadal Older Men
Arch Gen Psychiatry, February 1, 2004; 61(2): 162 - 167.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
E. L. Rhoden and A. Morgentaler
Risks of Testosterone-Replacement Therapy and Recommendations for Monitoring
N. Engl. J. Med., January 29, 2004; 350(5): 482 - 492.
[Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. E. Morley
The Top 10 Hot Topics in Aging
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2004; 59(1): M24 - 33.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. von Eckardstein, G. Noe, V. Brache, E. Nieschlag, H. Croxatto, F. Alvarez, A. Moo-Young, I. Sivin, N. Kumar, M. Small, et al.
A Clinical Trial of 7{alpha}-Methyl-19-Nortestosterone Implants for Possible Use as a Long-Acting Contraceptive for Men
J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5232 - 5239.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Szulc, B. Claustrat, F. Marchand, and P. D. Delmas
Increased Risk of Falls and Increased Bone Resorption in Elderly Men with Partial Androgen Deficiency: The MINOS Study
J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5240 - 5247.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
S. Bhasin
Testosterone Supplementation for Aging-Associated Sarcopenia
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2003; 58(11): M1002 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Doherty
Invited Review: Aging and sarcopenia
J Appl Physiol, October 1, 2003; 95(4): 1717 - 1727.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M.-M. G. Wilson and J. E. Morley
Invited Review: Aging and energy balance
J Appl Physiol, October 1, 2003; 95(4): 1728 - 1736.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
C. A. Thompson, T. D. Shanafelt, and C. L. Loprinzi
Andropause: Symptom Management for Prostate Cancer Patients Treated With Hormonal Ablation
Oncologist, October 1, 2003; 8(5): 474 - 487.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Y. Liu, B. Yee, S. M. Wishart, M. Jimenez, D. G. Jung, R. R. Grunstein, and D. J. Handelsman
The Short-Term Effects of High-Dose Testosterone on Sleep, Breathing, and Function in Older Men
J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3605 - 3613.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
M. M. Cherrier, S. Craft, and A. H. Matsumoto
Cognitive Changes Associated With Supplementation of Testosterone or Dihydrotestosterone in Mildly Hypogonadal Men: A Preliminary Report
J Androl, July 1, 2003; 24(4): 568 - 576.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. E. Morley
The Need for a Men's Health Initiative
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): M614 - 617.
[Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
G. A. Wittert, I. M. Chapman, M. T. Haren, S. Mackintosh, P. Coates, and J. E. Morley
Oral Testosterone Supplementation Increases Muscle and Decreases Fat Mass in Healthy Elderly Males With Low-Normal Gonadal Status
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): M618 - 625.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M.-M. G. Wilson
"PREEMPTIVE STRIKE?": SARCOPENIA AND NUTRITIONAL INTERVENTION
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): M672 - 673.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
M. Fukui, Y. Kitagawa, N. Nakamura, M. Kadono, S. Mogami, C. Hirata, N. Ichio, K. Wada, G. Hasegawa, and T. Yoshikawa
Association Between Serum Testosterone Concentration and Carotid Atherosclerosis in Men With Type 2 Diabetes
Diabetes Care, June 1, 2003; 26(6): 1869 - 1873.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
S. Bhasin, A. B. Singh, R. P. Mac, B. Carter, M. I. Lee, and G. R. Cunningham
Managing the Risks of Prostate Disease During Testosterone Replacement Therapy in Older Men: Recommendations for a Standardized Monitoring Plan
J Androl, May 1, 2003; 24(3): 299 - 311.
[Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. E. Morley and H. M. Perry III
Androgens and Women at the Menopause and Beyond
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2003; 58(5): M409 - 416.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. J. Woodhouse, S. Reisz-Porszasz, M. Javanbakht, T. W. Storer, M. Lee, H. Zerounian, and S. Bhasin
Development of models to predict anabolic response to testosterone administration in healthy young men
Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E1009 - E1017.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
F. C. W. Wu and A. von Eckardstein
Androgens and Coronary Artery Disease
Endocr. Rev., April 1, 2003; 24(2): 183 - 217.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. W. Storer, L. Magliano, L. Woodhouse, M. L. Lee, C. Dzekov, J. Dzekov, R. Casaburi, and S. Bhasin
Testosterone Dose-Dependently Increases Maximal Voluntary Strength and Leg Power, but Does Not Affect Fatigability or Specific Tension
J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1478 - 1485.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
W. A. Banks and J. E. Morley
Memories Are Made of This: Recent Advances in Understanding Cognitive Impairments and Dementia
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2003; 58(4): M314 - 321.
[Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
S. H. Tariq MD
KNOWLEDGE ABOUT LOW TESTOSTERONE IN OLDER MEN
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2003; 58(4): M382 - 383.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. J. Lee, J. McClung, G. A. Hand, and J. A. Carson
Overload-induced androgen receptor expression in the aged rat hindlimb receiving nandrolone decanoate
J Appl Physiol, March 1, 2003; 94(3): 1153 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. L. Herbst, B. D. Anawalt, J. K. Amory, A. M. Matsumoto, and W. J. Bremner
The Male Contraceptive Regimen of Testosterone and Levonorgestrel Significantly Increases Lean Mass in Healthy Young Men in 4 Weeks, but Attenuates a Decrease in Fat Mass Induced by Testosterone Alone
J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1167 - 1173.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
H. T. Blumenthal
The Aging-Disease Dichotomy: True or False?
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2003; 58(2): M138 - 145.
[Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
C. P. Lambert, D. H. Sullivan, and W. J. Evans
Effects of Testosterone Replacement and/or Resistance Training on Interleukin-6, Tumor Necrosis Factor Alpha, and Leptin in Elderly Men Ingesting Megestrol Acetate: A Randomized Controlled Trial
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2003; 58(2): M165 - 170.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. T. Schroeder, A. Singh, S. Bhasin, T. W. Storer, C. Azen, T. Davidson, C. Martinez, I. Sinha-Hikim, S. V. Jaque, M. Terk, et al.
Effects of an oral androgen on muscle and metabolism in older, community-dwelling men
Am J Physiol Endocrinol Metab, January 1, 2003; 284(1): E120 - E128.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. T. Brill, A. L. Weltman, A. Gentili, J. T. Patrie, D. A. Fryburg, J. B. Hanks, R. J. Urban, and J. D. Veldhuis
Single and Combined Effects of Growth Hormone and Testosterone Administration on Measures of Body Composition, Physical Performance, Mood, Sexual Function, Bone Turnover, and Muscle Gene Expression in Healthy Older Men
J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5649 - 5657.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M. Iannuzzi-Sucich, K. M. Prestwood, and A. M. Kenny
Prevalence of Sarcopenia and Predictors of Skeletal Muscle Mass in Healthy, Older Men and Women
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2002; 57(12): M772 - 777.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. R. Blackman, J. D. Sorkin, T. Munzer, M. F. Bellantoni, J. Busby-Whitehead, T. E. Stevens, J. Jayme, K. G. O'Connor, C. Christmas, J. D. Tobin, et al.
Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men: A Randomized Controlled Trial
JAMA, November 13, 2002; 288(18): 2282 - 2292.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Kilciler, M. Ozata, C. Oktenli, S.Y. Sanisoglu, E. Bolu, N. Bingol, M. Kilciler, I. C. Ozdemir, and M. Kutlu
Diurnal Leptin Secretion Is Intact in Male Hypogonadotropic Hypogonadism and Is Not Influenced by Exogenous Gonadotropins
J. Clin. Endocrinol. Metab., November 1, 2002; 87(11): 5023 - 5029.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
R. E. Gerstenbluth, P. N. Maniam, E. W. Corty, and A. D. Seftel
Prostate-Specific Antigen Changes in Hypogonadal Men Treated With Testosterone Replacement
J Androl, November 1, 2002; 23(6): 922 - 926.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. E. Morley, H. M. Perry III, and D. K. Miller
Editorial: Something About Frailty
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2002; 57(11): M698 - 704.
[Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
A. Fisher and J. E. Morley
Editorial: Antiaging Medicine: The Good, the Bad, and the Ugly
J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2002; 57(10): M636 - 639.
[Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. E. Morley
Editorial: A Fall Is a Major Event in the Life of an Older Person
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2002; 57(8): M492 - 495.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. A. Roy, M. R. Blackman, S. M. Harman, J. D. Tobin, M. Schrager, and E. J. Metter
Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men
Am J Physiol Endocrinol Metab, August 1, 2002; 283(2): E284 - E294.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. M. Cherrier, B. D. Anawalt, K. L. Herbst, J. K. Amory, S. Craft, A. M. Matsumoto, and W. J. Bremner
Cognitive Effects of Short-Term Manipulation of Serum Sex Steroids in Healthy Young Men
J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3090 - 3096.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Y. Liu, S. M. Wishart, and D. J. Handelsman
A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Recombinant Human Chorionic Gonadotropin on Muscle Strength and Physical Function and Activity in Older Men with Partial Age-Related Androgen Deficiency
J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3125 - 3135.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
A. M. Kenny, K. M. Prestwood, C. A. Gruman, G. Fabregas, B. Biskup, and G. Mansoor
Effects of Transdermal Testosterone on Lipids and Vascular Reactivity in Older Men With Low Bioavailable Testosterone Levels
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2002; 57(7): M460 - 465.
[Abstract] [Full Text]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. E. Morley and J. H. Flaherty
Editorial It's Never Too Late: Health Promotion and Illness Prevention in Older Persons
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2002; 57(6): M338 - 342.
[Full Text]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
A. M. Kenny, S. Bellantonio, C. A. Gruman, R. D. Acosta, and K. M. Prestwood
Effects of Transdermal Testosterone on Cognitive Function and Health Perception in Older Men With Low Bioavailable Testosterone Levels
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2002; 57(5): M321 - 325.
[Abstract] [Full Text]

Home page
 Arch NeurolHome page
M. S. Okun, W. M. McDonald, and M. R. DeLong
Refractory Nonmotor Symptoms in Male Patients With Parkinson Disease Due to Testosterone Deficiency: A Common Unrecognized Comorbidity
Arch Neurol, May 1, 2002; 59(5): 807 - 811.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Wang and R. S. Swerdloff
Should the Nonaromatizable Androgen Dihydrotestosterone Be Considered as an Alternative to Testosterone in the Treatment of the Andropause?
J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1462 - 1466.
[Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
A. M. Matsumoto
Andropause: Clinical Implications of the Decline in Serum Testosterone Levels With Aging in Men
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2002; 57(2): M76 - 99.
[Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. B. Singh, S. Hsia, P. Alaupovic, I. Sinha-Hikim, L. Woodhouse, T. A. Buchanan, R. Shen, R. Bross, N. Berman, and S. Bhasin
The Effects of Varying Doses of T on Insulin Sensitivity, Plasma Lipids, Apolipoproteins, and C-Reactive Protein in Healthy Young Men
J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 136 - 143.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. E. Morley
Editorial: Drugs, Aging, and the Future
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2002; 57(1): M2 - 6.
[Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
C. Christmas, K. G. O'Connor, S. M. Harman, J. D. Tobin, T. Munzer, M. F. Bellantoni, C. St. Clair, K. M. Pabst, J. D. Sorkin, and M. R. Blackman
Growth Hormone and Sex Steroid Effects on Bone Metabolism and Bone Mineral Density in Healthy Aged Women and Men
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2002; 57(1): M12 - 18.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
F. L. Malphurs and J. A. Striano
Gaze Into the Long-term Care Crystal Ball: The Veterans Health Administration and Aging
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2001; 56(11): M666 - 673.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1997 by The Endocrine Society