| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Reproductive Endocrinology |
Reproductive Endocrinology Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143-0556
Address all correspondence and requests for reprints to: Dr. Robert N. Taylor, Reproductive Endocrinology Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143-0556.
Retrograde menstruation is postulated as the initiating event in the
histogenesis of endometriosis; however, subsequent steps in the
pathogenesis of this common disorder remain poorly characterized. The
ip accumulation of activated leukocytes and the infiltration of
endometriosis lesions by macrophages and T cells are cytological
markers of the inflammatory nature of this syndrome. The apparent
recruitment of these leukocytes prompted us to search for chemokine
expression by endometriosis cells. We reported previously that pelvic
fluid RANTES (regulated upon activation, normal T cell expressed and
secreted) concentrations correlated with the stage of endometriosis. In
the current study, RANTES messenger ribonucleic acid (mRNA) was
identified in normal endometrium and endometriosis lesions, and
techniques were developed to localize RANTES protein within these
tissues. Using isolated endometrial and endometriosis cell cultures, we
demonstrated that RANTES mRNA and protein can be induced by the
proinflammatory cytokines tumor necrosis factor-
and interferon-
in endometrial stromal, but not in epithelial or adenocarcinoma cells.
Immunocytochemical studies confirmed the biochemical findings.
Metabolic labeling experiments verified that nascent RANTES secreted by
cytokine-stimulated endometriosis stromal cells was the mature, 8-kDa
protein predicted by the mRNA encoding this chemokine. The results
indicate that RANTES is a normal constituent of the eutopic
endometrium. We propose that secretion of RANTES by ectopic
endometriosis implants provides a mechanism for peritoneal leukocyte
recruitment.
This article has been cited by other articles:
 |
|
 |
|
  H. Zhang, M. Li, X. Zheng, Y. Sun, Z. Wen, and X. Zhao Endometriotic stromal cells lose the ability to regulate cell-survival signaling in endometrial epithelial cells in vitro Mol. Hum. Reprod., October 1, 2009; 15(10): 653 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Wieser, J. Yu, J. Park, A. Gaeddert, M. Cohen, J.-L. Vigne, and R. N. Taylor A Botanical Extract from Channel Flow Inhibits Cell Proliferation, Induces Apoptosis, and Suppresses CCL5 in Human Endometriotic Stromal Cells Biol Reprod, August 1, 2009; 81(2): 371 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ngo, C. Chereau, C. Nicco, B. Weill, C. Chapron, and F. Batteux Reactive Oxygen Species Controls Endometriosis Progression Am. J. Pathol., July 1, 2009; 175(1): 225 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Weiss, L. T. Goldsmith, R. N. Taylor, D. Bellet, and H. S. Taylor Inflammation in Reproductive Disorders Reproductive Sciences, February 1, 2009; 16(2): 216 - 229. [Abstract] [PDF]
|
|
|
|
 |
|
 S. E. Bulun Endometriosis N. Engl. J. Med., January 15, 2009; 360(3): 268 - 279. [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Lengi, R. A. Phillips, E. Karpuzoglu, and S. A. Ahmed Estrogen selectively regulates chemokines in murine splenocytes J. Leukoc. Biol., April 1, 2007; 81(4): 1065 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Thirkill, H. Vedagiri, and G. C. Douglas Macaque Trophoblast Migration toward RANTES Is Inhibited by Cigarette Smoke-Conditioned Medium Toxicol. Sci., June 1, 2006; 91(2): 557 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamaguchi, K. Kitaya, N. Daikoku, T. Yasuo, S. Fushiki, and H. Honjo Potential Selectin L Ligands Involved in Selective Recruitment of Peripheral Blood CD16(-) Natural Killer Cells into Human Endometrium Biol Reprod, January 1, 2006; 74(1): 35 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M Schaefer, J. A. Wright, P. A. Pioli, and C. R. Wira IL-1{beta}-Mediated Proinflammatory Responses Are Inhibited by Estradiol via Down-Regulation of IL-1 Receptor Type I in Uterine Epithelial Cells J. Immunol., November 15, 2005; 175(10): 6509 - 6516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Dimitriadis, C.A. White, R.L. Jones, and L.A. Salamonsen Cytokines, chemokines and growth factors in endometrium related to implantation Hum. Reprod. Update, November 1, 2005; 11(6): 613 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Jones, N. B. Morison, N. J. Hannan, H. O.D. Critchley, and L. A. Salamonsen Chemokine expression is dysregulated in the endometrium of women using progestin-only contraceptives and correlates to elevated recruitment of distinct leukocyte populations Hum. Reprod., October 1, 2005; 20(10): 2724 - 2735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wu, L.-P. Jin, M.-M. Yuan, Y. Zhu, M.-Y. Wang, and D.-J. Li Human First-Trimester Trophoblast Cells Recruit CD56brightCD16- NK Cells into Decidua by Way of Expressing and Secreting of CXCL12/Stromal Cell-Derived Factor 1 J. Immunol., July 1, 2005; 175(1): 61 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Tanmahasamut and N. Sidell Up-Regulation of Gap Junctional Intercellular Communication and Connexin43 Expression by Retinoic Acid in Human Endometrial Stromal Cells J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4151 - 4156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Hannan, R. L. Jones, H. O. D. Critchley, G. J. Kovacs, P. A. W. Rogers, B. Affandi, and L. A. Salamonsen Coexpression of Fractalkine and Its Receptor in Normal Human Endometrium and in Endometrium from Users of Progestin-Only Contraception Supports a Role for Fractalkine in Leukocyte Recruitment and Endometrial Remodeling J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6119 - 6129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Jones, N. J. Hannan, T. J. Kaitu'u, J. Zhang, and L. A. Salamonsen Identification of Chemokines Important for Leukocyte Recruitment to the Human Endometrium at the Times of Embryo Implantation and Menstruation J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6155 - 6167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Curry Jr. and K. G. Osteen The Matrix Metalloproteinase System: Changes, Regulation, and Impact throughout the Ovarian and Uterine Reproductive Cycle Endocr. Rev., August 1, 2003; 24(4): 428 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Antinolo, R.M. Fernandez, J.A. Noval, J.C. Garcia-Lozano, S. Borrego, I. Marcos, and J.L. Molini Evaluation of germline sequence variants within the promoter region of RANTES gene in a cohort of women with endometriosis from Spain Mol. Hum. Reprod., August 1, 2003; 9(8): 491 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mulayim, S. F. Palter, U. A. Kayisli, L. Senturk, and A. Arici Chemokine Receptor Expression in Human Endometrium Biol Reprod, May 1, 2003; 68(5): 1491 - 1495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Akoum, A. Lemay, and R. Maheux Estradiol and Interleukin-1{beta} Exert a Synergistic Stimulatory Effect on the Expression of the Chemokine Regulated upon Activation, Normal T Cell Expressed, and Secreted in Endometriotic Cells J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5785 - 5792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Sun, K. Nasu, J. Fukuda, S. Mine, M. Nishida, and I. Miyakawa Expression of macrophage inflammatory protein-3{alpha} in an endometrial epithelial cell line, HHUA, and cultured human endometrial stromal cells Mol. Hum. Reprod., October 1, 2002; 8(10): 930 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhao, E. A. Pritts, V. A. Chao, J.-F. Savouret, and R. N. Taylor Dioxin stimulates RANTES expression in an in-vitro model of endometriosis Mol. Hum. Reprod., September 1, 2002; 8(9): 849 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhao, D. I. Lebovic, and R. N. Taylor Long-Term Progestin Treatment Inhibits RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) Gene Expression in Human Endometrial Stromal Cells J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2514 - 2519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Pritts, D. Zhao, E. Ricke, L. Waite, and R. N. Taylor PPAR-{gamma} Decreases Endometrial Stromal Cell Transcription and Translation of RANTES in Vitro J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1841 - 1844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Caballero-Campo, F. Dominguez, J. Coloma, M. Meseguer, J. Remohi, A. Pellicer, and C. Simon Hormonal and embryonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrium during the window of implantation Mol. Hum. Reprod., April 1, 2002; 8(4): 375 - 384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Red-Horse, P. M. Drake, M. D. Gunn, and S. J. Fisher Chemokine Ligand and Receptor Expression in the Pregnant Uterus : Reciprocal Patterns in Complementary Cell Subsets Suggest Functional Roles Am. J. Pathol., December 1, 2001; 159(6): 2199 - 2213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. I. Lebovic, V. A. Chao, J.-F. Martini, and R. N. Taylor IL-1{beta} Induction of RANTES (Regulated upon Activation, Normal T Cell Expressed and Secreted) Chemokine Gene Expression in Endometriotic Stromal Cells Depends on a Nuclear Factor-{kappa}B Site in the Proximal Promoter J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4759 - 4764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Akoum, C. Lawson, S. McColl, and M. Villeneuve Ectopic endometrial cells express high concentrations of interleukin (IL)-8 in vivo regardless of the menstrual cycle phase and respond to oestradiol by up-regulating IL-1-induced IL-8 expression in vitro Mol. Hum. Reprod., September 1, 2001; 7(9): 859 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hornung, L. L. Waite, E. A. Ricke, F. Bentzien, D. Wallwiener, and R. N. Taylor Nuclear Peroxisome Proliferator-Activated Receptors {{alpha}} and {{gamma}} Have Opposing Effects on Monocyte Chemotaxis in Endometriosis J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3108 - 3114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hornung, K. Klingel, K. Dohrn, R. Kandolf, D. Wallwiener, and R. N. Taylor Regulated on Activation, Normal T-Cell-Expressed and -Secreted mRNA Expression in Normal Endometrium and Endometriotic Implants : Assessment of Autocrine/Paracrine Regulation by in Situ Hybridization Am. J. Pathol., June 1, 2001; 158(6): 1949 - 1954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Drake, M. D. Gunn, I. F. Charo, C.-L. Tsou, Y. Zhou, L. Huang, and S. J. Fisher Human Placental Cytotrophoblasts Attract Monocytes and Cd56bright Natural Killer Cells via the Actions of Monocyte Inflammatory Protein 1{alpha} J. Exp. Med., May 21, 2001; 193(10): 1199 - 1212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sugano, H. Narahara, K. Nasu, K. Arima, K. Fujisawa, and I. Miyakawa Effects of platelet-activating factor on cytokine production by human uterine cervical fibroblasts Mol. Hum. Reprod., May 1, 2001; 7(5): 475 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hornung, F. Bentzien, D. Wallwiener, L. Kiesel, and R.N. Taylor Chemokine bioactivity of RANTES in endometriotic and normal endometrial stromal cells and peritoneal fluid Mol. Hum. Reprod., February 1, 2001; 7(2): 163 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hornung, K. Dohrn, K. Sotlar, R. R. Greb, D. Wallwiener, L. Kiesel, and R. N. Taylor Localization in Tissues and Secretion of Eotaxin by Cells from Normal Endometrium and Endometriosis J. Clin. Endocrinol. Metab., July 1, 2000; 85(7): 2604 - 2608. [Abstract] [Full Text]
|
|
|
|
|
|
A. Boucher, W. Mourad, J. Mailloux, A. Lemay, and A. Akoum Ovarian hormones modulate monocyte chemotactic protein-1 expression in endometrial cells of women with endometriosis Mol. Hum. Reprod., July 1, 2000; 6(7): 618 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Blumenthal, M. Samoszuk, A. P. Taylor, G. Brown, R. Alisauskas, and D. M. Goldenberg Degranulating Eosinophils in Human Endometriosis Am. J. Pathol., May 1, 2000; 156(5): 1581 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Arima, K. Nasu, H. Narahara, K. Fujisawa, N. Matsui, and I. Miyakawa Effects of lipopolysaccharide and cytokines on production of RANTES by cultured human endometrial stromal cells Mol. Hum. Reprod., March 1, 2000; 6(3): 246 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. I. Lebovic, F. Bentzien, V. A. Chao, E. N. Garrett, Y.G. Meng, and R. N. Taylor Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1{beta} Mol. Hum. Reprod., March 1, 2000; 6(3): 269 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Akoum, C. Jolicoeur, and A. Boucher Estradiol Amplifies Interleukin-1-Induced Monocyte Chemotactic Protein-1 Expression by Ectopic Endometrial Cells of Women with Endometriosis J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 896 - 904. [Abstract] [Full Text]
|
|
|
|
|
|
J. Zhang, L. J. Lathbury, and L. A. Salamonsen Expression of the Chemokine Eotaxin and Its Receptor, CCR3, in Human Endometrium Biol Reprod, February 1, 2000; 62(2): 404 - 411. [Abstract] [Full Text]
|
|
|
|
|
|
A. Arici, L. M. Senturk, E. Seli, M. O. Bahtiyar, and G. Kim Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone Biol Reprod, July 1, 1999; 61(1): 85 - 90. [Abstract] [Full Text]
|
|
|
|
|
|
A.J. Vincent, N. Malakooti, J. Zhang, P.A.W. Rogers, B. Affandi, and L.A. Salamonsen Endometrial breakdown in women using Norplant is associated with migratory cells expressing matrix metalloproteinase-9 (gelatinase B) Hum. Reprod., March 1, 1999; 14(3): 807 - 815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Ayad, J. M. Stark, M. M. Fiedler, I. Y. Menendez, M. A. Ryan, and H. R. Wong The Heat Shock Response Inhibits RANTES Gene Expression in Cultured Human Lung Epithelium J. Immunol., September 1, 1998; 161(5): 2594 - 2599. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
