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Reproductive Endocrinology |
Reproductive Endocrinology Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143-0556
Address all correspondence and requests for reprints to: Dr. Robert N. Taylor, Reproductive Endocrinology Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143-0556.
Retrograde menstruation is postulated as the initiating event in the
histogenesis of endometriosis; however, subsequent steps in the
pathogenesis of this common disorder remain poorly characterized. The
ip accumulation of activated leukocytes and the infiltration of
endometriosis lesions by macrophages and T cells are cytological
markers of the inflammatory nature of this syndrome. The apparent
recruitment of these leukocytes prompted us to search for chemokine
expression by endometriosis cells. We reported previously that pelvic
fluid RANTES (regulated upon activation, normal T cell expressed and
secreted) concentrations correlated with the stage of endometriosis. In
the current study, RANTES messenger ribonucleic acid (mRNA) was
identified in normal endometrium and endometriosis lesions, and
techniques were developed to localize RANTES protein within these
tissues. Using isolated endometrial and endometriosis cell cultures, we
demonstrated that RANTES mRNA and protein can be induced by the
proinflammatory cytokines tumor necrosis factor-
and interferon-
in endometrial stromal, but not in epithelial or adenocarcinoma cells.
Immunocytochemical studies confirmed the biochemical findings.
Metabolic labeling experiments verified that nascent RANTES secreted by
cytokine-stimulated endometriosis stromal cells was the mature, 8-kDa
protein predicted by the mRNA encoding this chemokine. The results
indicate that RANTES is a normal constituent of the eutopic
endometrium. We propose that secretion of RANTES by ectopic
endometriosis implants provides a mechanism for peritoneal leukocyte
recruitment.
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A. Akoum, A. Lemay, and R. Maheux Estradiol and Interleukin-1{beta} Exert a Synergistic Stimulatory Effect on the Expression of the Chemokine Regulated upon Activation, Normal T Cell Expressed, and Secreted in Endometriotic Cells J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5785 - 5792. [Abstract] [Full Text] [PDF]
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B. Sun, K. Nasu, J. Fukuda, S. Mine, M. Nishida, and I. Miyakawa Expression of macrophage inflammatory protein-3{alpha} in an endometrial epithelial cell line, HHUA, and cultured human endometrial stromal cells Mol. Hum. Reprod., October 1, 2002; 8(10): 930 - 933. [Abstract] [Full Text] [PDF]
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D. Zhao, E. A. Pritts, V. A. Chao, J.-F. Savouret, and R. N. Taylor Dioxin stimulates RANTES expression in an in-vitro model of endometriosis Mol. Hum. Reprod., September 1, 2002; 8(9): 849 - 854. [Abstract] [Full Text] [PDF]
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D. I. Lebovic, V. A. Chao, J.-F. Martini, and R. N. Taylor IL-1{beta} Induction of RANTES (Regulated upon Activation, Normal T Cell Expressed and Secreted) Chemokine Gene Expression in Endometriotic Stromal Cells Depends on a Nuclear Factor-{kappa}B Site in the Proximal Promoter J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4759 - 4764. [Abstract] [Full Text] [PDF]
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T. Sugano, H. Narahara, K. Nasu, K. Arima, K. Fujisawa, and I. Miyakawa Effects of platelet-activating factor on cytokine production by human uterine cervical fibroblasts Mol. Hum. Reprod., May 1, 2001; 7(5): 475 - 481. [Abstract] [Full Text] [PDF]
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D. Hornung, F. Bentzien, D. Wallwiener, L. Kiesel, and R.N. Taylor Chemokine bioactivity of RANTES in endometriotic and normal endometrial stromal cells and peritoneal fluid Mol. Hum. Reprod., February 1, 2001; 7(2): 163 - 168. [Abstract] [Full Text] [PDF]
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D. Hornung, K. Dohrn, K. Sotlar, R. R. Greb, D. Wallwiener, L. Kiesel, and R. N. Taylor Localization in Tissues and Secretion of Eotaxin by Cells from Normal Endometrium and Endometriosis J. Clin. Endocrinol. Metab., July 1, 2000; 85(7): 2604 - 2608. [Abstract] [Full Text]
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A. Boucher, W. Mourad, J. Mailloux, A. Lemay, and A. Akoum Ovarian hormones modulate monocyte chemotactic protein-1 expression in endometrial cells of women with endometriosis Mol. Hum. Reprod., July 1, 2000; 6(7): 618 - 626. [Abstract] [Full Text] [PDF]
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R. D. Blumenthal, M. Samoszuk, A. P. Taylor, G. Brown, R. Alisauskas, and D. M. Goldenberg Degranulating Eosinophils in Human Endometriosis Am. J. Pathol., May 1, 2000; 156(5): 1581 - 1588. [Abstract] [Full Text] [PDF]
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K. Arima, K. Nasu, H. Narahara, K. Fujisawa, N. Matsui, and I. Miyakawa Effects of lipopolysaccharide and cytokines on production of RANTES by cultured human endometrial stromal cells Mol. Hum. Reprod., March 1, 2000; 6(3): 246 - 251. [Abstract] [Full Text] [PDF]
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D. I. Lebovic, F. Bentzien, V. A. Chao, E. N. Garrett, Y.G. Meng, and R. N. Taylor Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1{beta} Mol. Hum. Reprod., March 1, 2000; 6(3): 269 - 275. [Abstract] [Full Text] [PDF]
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A. Akoum, C. Jolicoeur, and A. Boucher Estradiol Amplifies Interleukin-1-Induced Monocyte Chemotactic Protein-1 Expression by Ectopic Endometrial Cells of Women with Endometriosis J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 896 - 904. [Abstract] [Full Text]
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J. Zhang, L. J. Lathbury, and L. A. Salamonsen Expression of the Chemokine Eotaxin and Its Receptor, CCR3, in Human Endometrium Biol Reprod, February 1, 2000; 62(2): 404 - 411. [Abstract] [Full Text]
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A. Arici, L. M. Senturk, E. Seli, M. O. Bahtiyar, and G. Kim Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone Biol Reprod, July 1, 1999; 61(1): 85 - 90. [Abstract] [Full Text]
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A.J. Vincent, N. Malakooti, J. Zhang, P.A.W. Rogers, B. Affandi, and L.A. Salamonsen Endometrial breakdown in women using Norplant is associated with migratory cells expressing matrix metalloproteinase-9 (gelatinase B) Hum. Reprod., March 1, 1999; 14(3): 807 - 815. [Abstract] [Full Text] [PDF]
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O. Ayad, J. M. Stark, M. M. Fiedler, I. Y. Menendez, M. A. Ryan, and H. R. Wong The Heat Shock Response Inhibits RANTES Gene Expression in Cultured Human Lung Epithelium J. Immunol., September 1, 1998; 161(5): 2594 - 2599. [Abstract] [Full Text] [PDF]
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