| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Clinical Studies |
Department of Medicine (To. S., S.I.), Jichi Medical School, Tochigi; Second Department of Medicine (K.A.), Tohoku University School of Medicine, Sendai; Department of Medicine (K.K.), Nagaoka Red Cross Hospital, Nagaoka; Department of Medicine (K.Y.), National Sakura Hospital, Sakura; Department of Medicine (K.S.), Tokyo Rosai Hospital, Tokyo; Department of Medicine (Ta. S.), Keio University School of Medicine, Tokyo; Second Department of Medicine (S.Y.), Chiba University School of Medicine, Chiba, Japan
Address all correspondence and requests for reprints to: Toshikazu Saito, M.D., Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji Minamikawachi, Tochigi 329-04 Japan.
The present study was undertaken to determine whether the nonpeptide V2 arginine vasopressin (AVP) antagonist 5-dimethylamino-1[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride (OPC-31260) produces water diuresis and improves hyponatremia in patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Eleven patients (9 males and 2 females, 64 ± 3.5 yr) with SIADH were included in the present protocol, which was comprised of 3 successive days. Day 1 was a control day, and on days 2 and 3 OPC-31260 was administered intravenously. Five blood and urine collections were made at 1–2 h intervals during the 6 h observation period each day. A single administration of 0.25 and 0.5 mg/kg OPC-31260 increased the 4 h cumulative urine volume and decreased urinary osmolality to below 225 mOsm/kg H2O. Such a diuretic effect was independent of an increase in urinary solute excretions. This aquaresis by 0.5 mg/kg OPC-31260 caused a significant increase in serum sodium level by approximately 3 mEq/L. The antagonistic effect of OPC-31260 lasted for 4 h when it was given intravenously. These results indicate that OPC-31260 is an effective therapeutic agent for hyponatremia in patients with SIADH.
This article has been cited by other articles:
 |
|
 |
|
  S. J. Whitmire Nutrition-Focused Evaluation and Management of Dysnatremias Nutr Clin Pract, April 1, 2008; 23(2): 108 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kazory and E. A. Ross Contemporary Trends in the Pharmacological and Extracorporeal Management of Heart Failure: A Nephrologic Perspective Circulation, February 19, 2008; 117(7): 975 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kazama, T. Arata, M. Michimata, R. Hatano, M. Suzuki, N. Miyama, S. Sanada, A. Sato, S. Satomi, Y. Ejima, et al. Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats Nephrol. Dial. Transplant., January 1, 2007; 22(1): 68 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Schrier, P. Gross, M. Gheorghiade, T. Berl, J. G. Verbalis, F. S. Czerwiec, C. Orlandi, and the SALT Investigators Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia N. Engl. J. Med., November 16, 2006; 355(20): 2099 - 2112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Soupart, P. Gross, J.-J. Legros, S. Alfoldi, D. Annane, H. M. Heshmati, and G. Decaux Successful Long-Term Treatment of Hyponatremia in Syndrome of Inappropriate Antidiuretic Hormone Secretion with Satavaptan (SR121463B), an Orally Active Nonpeptide Vasopressin V2-Receptor Antagonist Clin. J. Am. Soc. Nephrol., November 1, 2006; 1(6): 1154 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Chute, E. Taylor, J. Williams, F. Kaye, D. Venzon, and B. E. Johnson A Metabolic Study of Patients with Lung Cancer and Hyponatremia of Malignancy Clin. Cancer Res., February 1, 2006; 12(3): 888 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Miyazaki, Y. Yamamura, T. Onogawa, S. Nakamura, S. Kinoshita, S. Nakayama, H. Fujiki, and T. Mori Therapeutic Effects of Tolvaptan, a Potent, Selective Nonpeptide Vasopressin V2 Receptor Antagonist, in Rats with Acute and Chronic Severe Hyponatremia Endocrinology, July 1, 2005; 146(7): 3037 - 3043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Wong and J. G. Verbalis Vasopressin V2 receptor antagonists Cardiovasc Res, August 15, 2001; 51(3): 391 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Palm, D. Reimann, and P. Gross The role of V2 vasopressin antagonists in hyponatremia Cardiovasc Res, August 15, 2001; 51(3): 403 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Birnbaumer The V2 vasopressin receptor mutations and fluid homeostasis Cardiovasc Res, August 15, 2001; 51(3): 409 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. GROSS, D. REIMANN, J. HENSCHKOWSKI, and M. DAMIAN Treatment of Severe Hyponatremia: Conventional and Novel Aspects J. Am. Soc. Nephrol., February 1, 2001; 12(90001): 10S - 14. [Abstract] [Full Text]
|
|
|
|
|
|
H. J. Adrogue and N. E. Madias Hyponatremia N. Engl. J. Med., May 25, 2000; 342(21): 1581 - 1589. [Full Text] [PDF]
|
|
|
|
|
|
C. Palm and P. Gross V2-vasopressin receptor antagonistsmechanism of effect and clinical implications in hyponatraemia Nephrol. Dial. Transplant., November 1, 1999; 14(11): 2559 - 2562. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Saito, S.-e Ishikawa, F. Ando, N. Okada, T. Nakamura, I. Kusaka, M. Higashiyama, S. Nagasaka, and T. Saito Exaggerated Urinary Excretion of Aquaporin-2 in the Pathological State of Impaired Water Excretion Dependent upon Arginine Vasopressin J. Clin. Endocrinol. Metab., November 1, 1998; 83(11): 4034 - 4040. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
