This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gunnes, M. Articles by Lehmann, E. H. Search for Related Content PubMed PubMed Citation Articles by Gunnes, M. Articles by Lehmann, E. H.

Lack of Relationship between Vitamin D Receptor Genotype and Forearm Bone Gain in Healthy Children, Adolescents, and Young Adults¹

Center for Clinical Osteoporosis Research (M.G., E.H.L.), Haugesund; and Hormone Laboratory, Aker University Hospital (J.P.B., J.H.), and The Osteoporosis Clinic (J.H.), Oslo, Norway

Address all correspondence and requests for reprints to: Jens P. Berg, M.D., Ph.D., Hormone Laboratory, Aker University Hospital, Trondheimsveien 235, N-0514 Oslo, Norway.

Recent studies have suggested that genetic effects on bone mineral density (BMD) are related to allelic variation in the vitamin D receptor (VDR) gene. We examined 1) allelic influences of the VDR gene on BMD of the forearm, spine, hip, and whole body; and 2) allelic influences of the VDR gene on forearm BMD gain. Two hundred and seventy-three healthy boys and girls, aged 8.2–16.5 yr, at baseline were eligible. Forearm BMD was assessed with single photon absorptiometry at baseline. BMD gain was calculated as the annual percent change in BMD measured by single photon absorptiometry from the baseline and after 3.8 ± 0.1 (±SD) yr. Calcium intake and physical activity were assessed by a detailed questionnaire at baseline and after 1 yr. VDR alleles were determined by BsaMI endonuclease restriction fragment analysis after PCR amplification. No significant differences in forearm BMD gain or in BMD assessed at the forearm, spine, hip, and whole body were observed among the three VDR genotypes. These findings did not change after adjusting for environmental factors such as calcium intake and physical activity or age, weight, height, and changes in weight and height during the observation period. In conclusion, our data do not support the idea that VDR genotypes are related to BMD gain or to BMD at the forearm, hip, spine, and whole body in healthy boys and girls, aged 8–21 yr. VDR genotyping is probably of little use for the detection of individuals who would benefit from increased calcium and physical activity to increase their peak bone densities.

This article has been cited by other articles:

				F. F. Bezerra, G. M. K. Cabello, L. M. C. Mendonca, and C. M. Donangelo Bone Mass and Breast Milk Calcium Concentration Are Associated with Vitamin D Receptor Gene Polymorphisms in Adolescent Mothers J. Nutr., February 1, 2008; 138(2): 277 - 281. [Abstract] [Full Text] [PDF]

				A. d'Alesio, M. Garabedian, J. P. Sabatier, G. Guaydier-Souquieres, C. Marcelli, A. Lemacon, O. Walrant-Debray, and F. Jehan Two single-nucleotide polymorphisms in the human vitamin D receptor promoter change protein-DNA complex formation and are associated with height and vitamin D status in adolescent girls Hum. Mol. Genet., November 15, 2005; 14(22): 3539 - 3548. [Abstract] [Full Text] [PDF]

				J. A. Eisman Pharmacogenetics of the Vitamin D Receptor and Osteoporosis Drug Metab. Dispos., April 1, 2001; 29(4): 505 - 512. [Abstract] [Full Text]

				D A Nelson, P J Vande Vord, and P H Wooley Polymorphism in the vitamin D receptor gene and bone mass in African-American and white mothers and children: a preliminary report Ann Rheum Dis, August 1, 2000; 59(8): 626 - 630. [Abstract] [Full Text]

				M. Lorentzon, R. Lorentzon, and P. Nordström Vitamin D Receptor Gene Polymorphism Is Associated with Birth Height, Growth to Adolescence, and Adult Stature in Healthy Caucasian Men: A Cross-Sectional and Longitudinal Study J. Clin. Endocrinol. Metab., April 1, 2000; 85(4): 1666 - 1671. [Abstract] [Full Text]

				J. A. Eisman Genetics of Osteoporosis Endocr. Rev., December 1, 1999; 20(6): 788 - 804. [Abstract] [Full Text]

				S. Ferrari, D. Manen, J.-P. Bonjour, D. Slosman, and R. Rizzoli Bone Mineral Mass and Calcium and Phosphate Metabolism in Young Men: Relationships with Vitamin D Receptor Allelic Polymorphisms J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 2043 - 2048. [Abstract] [Full Text]

				C. Tao, T. Yu, S. Garnett, J. Briody, J. Knight, H. Woodhead, C. T Cowell;, and Z. MUGHAL Vitamin D receptor alleles predict growth and bone density in girls • Commentary Arch. Dis. Child., December 1, 1998; 79(6): 488 - 494. [Abstract] [Full Text]

				F. Suarez, C. Rossignol, and M. Garabédian Interactive Effect of Estradiol and Vitamin D Receptor Gene Polymorphisms as a Possible Determinant of Growth in Male and Female Infants J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3563 - 3568. [Abstract] [Full Text]