This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tauber, M. Articles by Rochiccioli, P. Search for Related Content PubMed PubMed Citation Articles by Tauber, M. Articles by Rochiccioli, P.

Growth Hormone (GH) Retesting and Auxological Data in 131 GH-Deficient Patients after Completion of Treatment

Service de Pédiatrie Endocrinologie, Centre, Hospitalier Universitoine, Purpan, F-31059 Toulouse Cedex, France

Address all correspondence and requests for reprints to: Maïthé Tauber, Service de Pédiatrie Endocrinologie, CHU Purpan, Place Baylac, F-31059 Toulouse Cedex, France.

GH state and auxological data after completion of GH therapy are reported in 131 patients (79 males, 52 females). They were treated from 1980–1994 for partial (n = 98) or complete (n = 33) GH deficiency (GHD), either idiopathic (n = 121) or organic (n = 10). A single stimulation test (clonidine + betaxolol) was used, and only 50 patients (38%) maintained a blunted response (GH peak below 10 µg/L). Although 9 of the 10 patients with organic GHD had an abnormal low GH peak, 67% of patients with idiopathic GHD normalized their GH secretion. This was particularly true of partial GHD patients (71% vs. 36% of complete GH-deficient patients). Based on a retest GH peak below 5 µg/L, only 23% of the patients were considered to be GH deficient and therefore candidates for GH treatment during adulthood. We found no significant difference between hormonal state at completion of treatment and initial GH deficiency, pubertal state, or sex, although we did find a significantly lower GH peak value before and after treatment in patients with elevated body mass index. Of the 14 obese children who were treated, 50% had an abnormally low serum insulin-like growth factor-I level, arguing for true GHD, and only two children remained obese at cessation of treatment. Auxological data showed that with a mean duration of treatment of 3.6 ± 2.0 yr, patients classified as having complete GHD before treatment had significantly greater catch-up growth as expressed in SDS for height than patients with partial GHD (0.6 ± 1.1 vs. 1.1 ± 0.7 SDS, P < 0.05), and that boys grew better than girls (1.4 ± 0.8 vs. 1.6 ± 0.6 SDS) for height, P < 0.01). That catch-up growth was not correlated with the result of GH peak after cessation of treatment.

This article has been cited by other articles:

				G. Corneli, C. Di Somma, F. Prodam, J. Bellone, S. Bellone, V. Gasco, R. Baldelli, S. Rovere, H. J. Schneider, L. Gargantini, et al. Cut-off limits of the GH response to GHRH plus arginine test and IGF-I levels for the diagnosis of GH deficiency in late adolescents and young adults Eur. J. Endocrinol., December 1, 2007; 157(6): 701 - 708. [Abstract] [Full Text] [PDF]

				G. Gelwane, C. Garel, D. Chevenne, P. Armoogum, D. Simon, P. Czernichow, and J. Leger Subnormal Serum Insulin-Like Growth Factor-I Levels in Young Adults with Childhood-Onset Nonacquired Growth Hormone (GH) Deficiency Who Recover Normal GH Secretion May Indicate Less Severe but Persistent Pituitary Failure J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3788 - 3795. [Abstract] [Full Text] [PDF]

				N. di Iorgi, A. Secco, F. Napoli, C. Tinelli, A. Calcagno, N. Fratangeli, L. Ambrosini, A. Rossi, R. Lorini, and M. Maghnie Deterioration of Growth Hormone (GH) Response and Anterior Pituitary Function in Young Adults with Childhood-Onset GH Deficiency and Ectopic Posterior Pituitary: A Two-Year Prospective Follow-Up Study J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3875 - 3884. [Abstract] [Full Text] [PDF]

				S. Zucchini, P. Pirazzoli, F. Baronio, M. Gennari, M. O. Bal, A. Balsamo, S. Gualandi, and A. Cicognani Effect on Adult Height of Pubertal Growth Hormone Retesting and Withdrawal of Therapy in Patients with Previously Diagnosed Growth Hormone Deficiency J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4271 - 4276. [Abstract] [Full Text] [PDF]

				M. Maghnie, L. Ambrosini, M. Cappa, G. Pozzobon, L. Ghizzoni, M. G. Ubertini, N. di Iorgi, C. Tinelli, S. Pilia, G. Chiumello, et al. Adult Height in Patients with Permanent Growth Hormone Deficiency with and without Multiple Pituitary Hormone Deficiencies J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 2900 - 2905. [Abstract] [Full Text] [PDF]

				M. E. Molitch, D. R. Clemmons, S. Malozowski, G. R. Merriam, S. M. Shalet, M. L. Vance, and for The Endocrine Society's Clinical Guidelines Su Evaluation and Treatment of Adult Growth Hormone Deficiency: An Endocrine Society Clinical Practice Guideline J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1621 - 1634. [Abstract] [Full Text] [PDF]

				M. Maghnie, G. Aimaretti, S. Bellone, G. Bona, J. Bellone, R. Baldelli, C. de Sanctis, L. Gargantini, R. Gastaldi, L. Ghizzoni, et al. Diagnosis of GH deficiency in the transition period: accuracy of insulin tolerance test and insulin-like growth factor-I measurement Eur. J. Endocrinol., April 1, 2005; 152(4): 589 - 596. [Abstract] [Full Text] [PDF]

				J. Leger, S. Danner, D. Simon, C. Garel, and P. Czernichow Do All Patients with Childhood-Onset Growth Hormone Deficiency (GHD) and Ectopic Neurohypophysis Have Persistent GHD in Adulthood? J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 650 - 656. [Abstract] [Full Text] [PDF]

				M. Lange, U. Feldt-Rasmussen, O. L. Svendsen, K. W. Kastrup, A. Juul, and J. Muller High Risk of Adrenal Insufficiency in Adults Previously Treated for Idiopathic Childhood Onset Growth Hormone Deficiency J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5784 - 5789. [Abstract] [Full Text] [PDF]

				M. Tauber, B. Jouret, A. Cartault, N. Lounis, M. Gayrard, C. Marcouyeux, C. Pienkowski, I. Oliver, P. Moulin, P. Otal, et al. Adolescents with Partial Growth Hormone (GH) Deficiency Develop Alterations of Body Composition after GH Discontinuation and Require Follow-Up J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5101 - 5106. [Abstract] [Full Text] [PDF]

				M. Tauber, B. Berro, V. Delagnes, N. Lounis, B. Jouret, C. Pienkowski, I. Oliver, and P. Rochiccioli Can Some Growth Hormone (GH)-Deficient Children Benefit from Combined Therapy with Gonadotropin-Releasing Hormone Analogs and GH? Results of a Retrospective Study J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1179 - 1183. [Abstract] [Full Text] [PDF]

				P. Saenger Growth hormone in growth hormone deficiency BMJ, July 13, 2002; 325(7355): 58 - 59. [Full Text] [PDF]

				M. E. Molitch Diagnosis of GH Deficiency in Adults--How Good Do the Criteria Need to Be? J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 473 - 476. [Full Text] [PDF]

				R. Coutant, S. Rouleau, F. Despert, N. Magontier, D. Loisel, and J.-M. Limal Growth and Adult Height in GH-Treated Children with Nonacquired GH Deficiency and Idiopathic Short Stature: The Influence of Pituitary Magnetic Resonance Imaging Findings J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4649 - 4654. [Abstract] [Full Text] [PDF]

				W. M. Drake, S. J. Howell, J. P. Monson, and S. M. Shalet Optimizing GH Therapy in Adults and Children Endocr. Rev., August 1, 2001; 22(4): 425 - 450. [Abstract] [Full Text] [PDF]

				J. W. Finkelstein, D. E. Rusovici, E. Green, S. Foreman, H. E. Kulin, M. R. D'Arcangelo, and R. Kemezys Children with Organic Growth Hormone Deficiency Have Elevated Cortisol Responses to Stimuli J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2854 - 2856. [Abstract] [Full Text] [PDF]

				A. S. MartÍnez, H. M. Domené, M. G. Ropelato, H. G. Jasper, P. A. Pennisi, M. E. Escobar, and J. J. Heinrich Estrogen Priming Effect on Growth Hormone (GH) Provocative Test: A Useful Tool for the Diagnosis of GH Deficiency J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4168 - 4172. [Abstract] [Full Text]

				G. Aimaretti, C. Baffoni, S. Bellone, L. Di Vito, G. Corneli, E. Arvat, L. Benso, F. Camanni, and E. Ghigo Retesting Young Adults with Childhood-Onset Growth Hormone (GH) Deficiency with GH-Releasing-Hormone-Plus-Arginine Test J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3693 - 3699. [Abstract] [Full Text]

				D. B. Allen Issues in the Transition From Childhood to Adult Growth Hormone Therapy Pediatrics, October 1, 1999; 104(4): 1004 - 1010. [Abstract] [Full Text]

				M. Maghnie, C. Strigazzi, C. Tinelli, M. Autelli, M. Cisternino, S. Loche, and F. Severi Growth Hormone (GH) Deficiency (GHD) of Childhood Onset: Reassessment of GH Status and Evaluation of the Predictive Criteria for Permanent GHD in Young Adults J. Clin. Endocrinol. Metab., April 1, 1999; 84(4): 1324 - 1328. [Abstract] [Full Text]

				G. P. August Symposium on Controversies in the Diagnosis of Growth Hormone Deficiency Pediatrics, August 1, 1998; 102(2): 517 - 517. [Full Text]

				S. M. Shalet, A. Toogood, A. Rahim, and B. M. D. Brennan The Diagnosis of Growth Hormone Deficiency in Children and Adults Endocr. Rev., April 1, 1998; 19(2): 203 - 223. [Abstract] [Full Text]

				R. Coutant, J.-C. Carel, M. Letrait, C. Bouvattier, P. Chatelain, J. Coste, and J.-L. Chaussain Short Stature Associated with Intrauterine Growth Retardation: Final Height of Untreated and Growth Hormone-Treated Children J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1070 - 1074. [Abstract] [Full Text]

				H. de Boer and E. A. van der Veen Why Retest Young Adults with Childhood-Onset Growth Hormone Deficiency? J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2032 - 2036. [Full Text] [PDF]

				R. G. Rosenfeld and M. D. Is Growth Hormone Deficiency a Viable Diagnosis? J. Clin. Endocrinol. Metab., February 1, 1997; 82(2): 349 - 351. [Full Text] [PDF]