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Diabetes during Pregnancy Does Not Alter Whole Body Bone Mineral Content in Infants

Department of Neonatology (A.L., S.G., O.C., B.L.S.), INSERM U-403 (A.L., P.D.D.), Human’s Nutrition Research Center (A.L., P.D.D., B.L.S.), and Department of Radiology (P.B.), Hôpital Edouard Herriot, Lyon, France

Address all correspondence and requests for reprints to: Alexandre Lapillonne, M.D., Department of Neonatology, Hôpital Edouard Herriot, 69437 Lyon Cedex 03, France.

A previous study using single photon absorptiometry has reported low bone mineral density of the radius in infants of diabetic mothers. The aim of this study was to assess by dual x-ray absorptiometry the whole body bone mineral content (WbBMC) and the body composition of 40 infants of diabetic mothers at birth (mean gestational age ± SD, 37.5 ± 1.3 weeks; mean birth weight ± SD, 3815 ± 641 g).

WbBMC was not correlated with gestational age, but was well correlated with birth weight (r = 0.73; P = 0.0001) and also with fat mass (r = 0.87; P = 0.0001) and lean mass (r = 0.42; P = 0.008). The z-scores ± SD adjusted for weight for WbBMC and fat mass were significantly increased (1.3 ± 0.9 and 2.6 ± 1.3, respectively (P < 0.0001), but were not significantly influenced either by in utero growth or by the type of the diabetes mellitus of the mother.

Bone mineralization and fat mass studied by whole body dual x-ray absorptiometry are increased at birth in these infants compared with reference curves.

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