| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Pediatric Endocrinology |
Department of Pediatrics, Division of Endocrinology, Sophia Children’s Hospital (A.B., S.M.K.S.), and the Department of Epidemiology and Biostatistics (M.R.), Department of Internal Medicine, Division of Endocrinology (H.P.), and Department of Nuclear Medicine (E.K.), Erasmus University, Rotterdam, The Netherlands
Address all correspondence and requests for reprints to: Dr. A. M. Boot, Sophia Children’s Hospital, Division of Endocrinology, dr. Molewaterplein 60, 3015 GJ Rotterdam, the Netherlands.
The association of height, weight, pubertal stage, calcium intake, and physical activity with bone mineral density (BMD) was evaluated in 500 children and adolescents (205 boys and 295 girls), aged 4–20 yr. The BMD (grams per cm2) of lumbar spine and total body was measured with dual energy x-ray absorptiometry. Lumbar spine volumetric BMD was calculated to correct for bone size. BMD and volumetric BMD increased with age. During puberty, the age-dependent increment was higher. After adjustment for age, the Tanner stage was significantly associated with all three BMD variables in girls and with spinal BMD in boys. In boys, positive correlations were found between BMD and both calcium intake and physical activity after adjustment for age. Stepwise regression analysis with weight, height, Tanner stage, calcium intake, and physical activity as determinants with adjustment for age resulted in a model with Tanner stage in girls and weight in boys for all three BMD variables. The major independent determinant of BMD was the Tanner stage in girls and weight in boys.
This article has been cited by other articles:
 |
|
 |
|
  R. H. Willemsen, S. P. Willemsen, and A. C. S. Hokken-Koelega Longitudinal Changes in Insulin Sensitivity and Body Composition of Small-For-Gestational-Age Adolescents after Cessation of Growth Hormone Treatment J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3449 - 3454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Sardinha, F. Baptista, and U. Ekelund Objectively Measured Physical Activity and Bone Strength in 9-Year-Old Boys and Girls Pediatrics, September 1, 2008; 122(3): e728 - e736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Chevalley, J.-P. Bonjour, S. Ferrari, and R. Rizzoli Influence of Age at Menarche on Forearm Bone Microstructure in Healthy Young Women J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2594 - 2601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Kelly, M. L. Van Natta, R. A. Covar, J. Tonascia, R. P. Green, R. C. Strunk, and for the CAMP Research Group Effect of Long-term Corticosteroid Use on Bone Mineral Density in Children: A Prospective Longitudinal Assessment in the Childhood Asthma Management Program (CAMP) Study Pediatrics, July 1, 2008; 122(1): e53 - e61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Willemsen, S. W. K. de Kort, D. C. M. van der Kaay, and A. C. S. Hokken-Koelega Independent Effects of Prematurity on Metabolic and Cardiovascular Risk Factors in Short Small-for-Gestational-Age Children J. Clin. Endocrinol. Metab., February 1, 2008; 93(2): 452 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Sheth, N. Binkley, and B. P. Hermann Progressive bone deficit in epilepsy Neurology, January 15, 2008; 70(3): 170 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z P Halaba, J Bursa, U Kostowska Kaplon, W Pluskiewicz, S Marciniak, and U Drzewiecka Phalangeal quantitative ultrasound measurements in former pre-term children aged 9 11 years Br. J. Radiol., June 1, 2007; 80(954): 401 - 405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A Ward, R. L Ashby, S. A Roberts, J. E Adams, and M Zulf Mughal UK reference data for the Hologic QDR Discovery dual-energy x ray absorptiometry scanner in healthy children and young adults aged 6-17 years Arch. Dis. Child., January 1, 2007; 92(1): 53 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Petryk, T. L. Bergemann, K. M. Polga, K. J. Ulrich, S. K. Raatz, D. M. Brown, L. L. Robison, and K. S. Baker Prospective Study of Changes in Bone Mineral Density and Turnover in Children after Hematopoietic Cell Transplantation J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 899 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Chevalley, J.-P. Bonjour, S. Ferrari, D. Hans, and R. Rizzoli Skeletal Site Selectivity in the Effects of Calcium Supplementation on Areal Bone Mineral Density Gain: A Randomized, Double-Blind, Placebo-Controlled Trial in Prepubertal Boys J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3342 - 3349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D J Chinn, J N Fordham, M S Kibirige, N J Crabtree, J Venables, J Bates, and O Pitcher Bone density at the os calcis: reference values, reproducibility, and effects of fracture history and physical activity Arch. Dis. Child., January 1, 2005; 90(1): 30 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Molgaard, B. L Thomsen, and K. F Michaelsen Effect of habitual dietary calcium intake on calcium supplementation in 12-14-y-old girls Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1422 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Arabi, H. Tamim, M. Nabulsi, J. Maalouf, H. Khalife, M. Choucair, R. Vieth, and G. El-Hajj Fuleihan Sex differences in the effect of body-composition variables on bone mass in healthy children and adolescents Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1428 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Markou, P. Mylonas, A. Theodoropoulou, A. Kontogiannis, M. Leglise, A. G. Vagenakis, and N. A. Georgopoulos The Influence of Intensive Physical Exercise on Bone Acquisition in Adolescent Elite Female and Male Artistic Gymnasts J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4383 - 4387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Horlick, J. Wang, R. N. Pierson Jr., and J. C. Thornton Prediction Models for Evaluation of Total-Body Bone Mass With Dual-Energy X-Ray Absorptiometry Among Children and Adolescents Pediatrics, September 1, 2004; 114(3): e337 - e345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. I. Baroncelli, S. Bertelloni, L. Galli, F. Sodini, and G. Saggese Are Adult Patients with Laron Syndrome Osteopenic? A Comparison between Dual-Energy X-Ray Absorptiometry and Volumetric Bone Densities J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2506 - 2507. [Full Text] [PDF]
|
|
|
|
|
|
J. O Fisher, D. C Mitchell, H. Smiciklas-Wright, M. L Mannino, and L. L Birch Meeting calcium recommendations during middle childhood reflects mother-daughter beverage choices and predicts bone mineral status Am. J. Clinical Nutrition, April 1, 2004; 79(4): 698 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Gourlay and S. A. Brown Clinical Considerations in Premenopausal Osteoporosis Arch Intern Med, March 22, 2004; 164(6): 603 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tauber, B. Jouret, A. Cartault, N. Lounis, M. Gayrard, C. Marcouyeux, C. Pienkowski, I. Oliver, P. Moulin, P. Otal, et al. Adolescents with Partial Growth Hormone (GH) Deficiency Develop Alterations of Body Composition after GH Discontinuation and Require Follow-Up J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5101 - 5106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Antoniazzi, G. Zamboni, F. Bertoldo, S. Lauriola, F. Mengarda, A. Pietrobelli, and L. Tato Bone Mass at Final Height in Precocious Puberty after Gonadotropin-Releasing Hormone Agonist with and without Calcium Supplementation J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1096 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Ducharme, G. Chabot, C. Polychronakos, F. Glorieux, and B. Mazer Safety Profile of Frequent Short Courses of Oral Glucocorticoids in Acute Pediatric Asthma: Impact on Bone Metabolism, Bone Density, and Adrenal Function Pediatrics, February 1, 2003; 111(2): 376 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I M van der Sluis, M A J de Ridder, A M Boot, E P Krenning, S M P F de Muinck Keizer-Schrama, and Z. Mughal Reference data for bone density and body composition measured with dual energy x ray absorptiometry in white children and young adults Arch. Dis. Child., October 1, 2002; 87(4): 341 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. I. Baroncelli, S. Bertelloni, F. Sodini, and G. Saggese Lumbar Bone Mineral Density at Final Height and Prevalence of Fractures in Treated Children with GH Deficiency J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3624 - 3631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Gravholt, A. L. Lauridsen, K. Brixen, L. Mosekilde, L. Heickendorff, and J. S. Christiansen Marked Disproportionality in Bone Size and Mineral, and Distinct Abnormalities in Bone Markers and Calcitropic Hormones in Adult Turner Syndrome: A Cross-Sectional Study J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2798 - 2808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. van der Sluis, A. M. Boot, E. P. Krenning, S. L. S. Drop, and S. M. P. F. de Muinck Keizer-Schrama Longitudinal Follow-Up of Bone Density and Body Composition in Children with Precocious or Early Puberty before, during and after Cessation of GnRH Agonist Therapy J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 506 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Carter, S. J. Whiting, D. T. Drinkwater, G. A. Zello, R. A. Faulkner, and D. A. Bailey Self-Reported Calcium Intake and Bone Mineral Content in Children and Adolescents J. Am. Coll. Nutr., October 1, 2001; 20(5): 502 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R H M Haslam, D J Borovnicar, D B Stroud, B J G Strauss, and J E Bines Correlates of prepubertal bone mineral density in cystic fibrosis Arch. Dis. Child., August 1, 2001; 85(2): 166 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Taha, D. Chin, A. I. Silverberg, L. Lashiker, N. Khateeb, and H. Anhalt Reduced Spinal Bone Mineral Density in Adolescents of an Ultra-Orthodox Jewish Community in Brooklyn Pediatrics, May 1, 2001; 107(5): 79e - 79. [Abstract] [Full Text]
|
|
|
|
|
|
J. J. B. Anderson Calcium Requirements during Adolescence to Maximize Bone Health J. Am. Coll. Nutr., April 1, 2001; 20(2): 186S - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Steelman and P. Zeitler Osteoporosis in Pediatrics Pediatr. Rev., February 1, 2001; 22(2): 56 - 65. [Full Text]
|
|
|
|
 |
|
 S P Conway, A M Morton, B Oldroyd, J G Truscott, H White, A H Smith, and I Haigh Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors Thorax, September 1, 2000; 55(9): 798 - 804. [Abstract] [Full Text]
|
|
|
|
|
|
N J Shaw, C M Boivin, and N J Crabtree Intravenous pamidronate in juvenile osteoporosis Arch. Dis. Child., August 1, 2000; 83(2): 143 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lloyd, V. M. Chinchilli, N. Johnson-Rollings, K. Kieselhorst, D. F. Eggli, and R. Marcus Adult Female Hip Bone Density Reflects Teenage Sports-Exercise Patterns But Not Teenage Calcium Intake Pediatrics, July 1, 2000; 106(1): 40 - 44. [Abstract] [Full Text]
|
|
|
|
|
|
M. Thearle, M. Horlick, J. P. Bilezikian, J. Levy, J. M. Gertner, L. S. Levine, M. Harbison, W. Berdon, and S. E. Oberfield Osteoporosis: An Unusual Presentation of Childhood Crohn's Disease J. Clin. Endocrinol. Metab., June 1, 2000; 85(6): 2122 - 2126. [Abstract] [Full Text]
|
|
|
|
|
|
K. A. Woods, C. Camacho-Hübner, R. N. Bergman, D. Barter, A. J. L. Clark, and M. O. Savage Effects of Insulin-Like Growth Factor I (IGF-I) Therapy on Body Composition and Insulin Resistance in IGF-I Gene Deletion J. Clin. Endocrinol. Metab., April 1, 2000; 85(4): 1407 - 1411. [Abstract] [Full Text]
|
|
|
|
|
|
Bone Mineral Acquisition in Healthy Asian, Hispanic, Black, and Caucasian Youth: A Longitudinal Study J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4702 - 4712. [Abstract] [Full Text]
|
|
|
|
|
|
H. S Barden, L M. Maynard, W. A Wisemandle, S. S Guo, C. M Zeller, W C. Chumlea, B. Towne, A. F Roche, and R. M Siervogel Reports of total-body bone mineral density Am. J. Clinical Nutrition, June 1, 1999; 69(6): 1289 - 1289. [Full Text]
|
|
|
|
|
|
F. Antoniazzi, F. Bertoldo, S. Lauriola, S. Sirpresi, E. Gasperi, G. Zamboni, and L. Tatò Prevention of Bone Demineralization by Calcium Supplementation in Precocious Puberty during Gonadotropin-Releasing Hormone Agonist Treatment J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 1992 - 1996. [Abstract] [Full Text]
|
|
|
|
|
|
G. I. Baroncelli, S. Bertelloni, C. Ceccarelli, and G. Saggese Measurement of Volumetric Bone Mineral Density Accurately Determines Degree of Lumbar Undermineralization in Children with Growth Hormone Deficiency--Author's Response J. Clin. Endocrinol. Metab., April 1, 1999; 84(4): 1490a - 1491. [Full Text]
|
|
|
|
|
|
G. I. Baroncelli, S. Bertelloni, C. Ceccarelli, and G. Saggese Measurement of Volumetric Bone Mineral Density Accurately Determines Degree of Lumbar Undermineralization in Children with Growth Hormone Deficiency J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3150 - 3154. [Abstract] [Full Text]
|
|
|
|
|
|
J C Y Cheng, S S S F Leung, W T K Lee, J T F Lau, N Maffulli, A Y K Cheung, and K M Chan Determinants of axial and peripheral bone mass in Chinese adolescents Arch. Dis. Child., June 1, 1998; 78(6): 524 - 530. [Abstract] [Full Text]
|
|
|
|
|
|
A. Maggioni Nutrition and Physical Activity with Particular Emphasis on Bone Health J. Am. Coll. Nutr., April 1, 1998; 17(2): 103 - 104. [Full Text] [PDF]
|
|
|
|
|
|
J. Z. Ilich, M. Skugor, T. Hangartner, A. Baosh, and V. Matkovic Relation of Nutrition, Body Composition and Physical Activity to Skeletal Development: A Cross-Sectional Study in Preadolescent Females J. Am. Coll. Nutr., April 1, 1998; 17(2): 136 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Boot, S. M. P. F. d. M. Keizer-Schrama, H. A. P. Pols, E. P. Krenning, and S. L. S. Drop Bone Mineral Density and Body Composition before and during Treatment with Gonadotropin-Releasing Hormone Agonist in Children with Central Precocious and Early Puberty J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 370 - 373. [Abstract] [Full Text]
|
|
|
|
 |
|
 A M Boot, J Bouquet, E P Krenning, and S M P F de Muinck Keizer-Schrama Bone mineral density and nutritional status in children with chronic inflammatory bowel disease Gut, February 1, 1998; 42(2): 188 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Boot, M. A. M. J. Engels, G. J. M. Boerma, E. P. Krenning, and S. M. P. F. de Muinck Keizer-Schrama Changes in Bone Mineral Density, Body Composition, and Lipid Metabolism during Growth Hormone (GH) Treatment in Children with GH Deficiency J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2423 - 2428. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
