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Journal of Clinical Endocrinology & Metabolism, Vol 81, 3341-3345, Copyright © 1996 by Endocrine Society


ARTICLES

Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction

BD Anawalt, RA Bebb, AM Matsumoto, NP Groome, PJ Illingworth, AS McNeilly and WJ Bremner
Department of Veterans Affairs Medical Center, Seattle, Washington, USA.

We used a recently developed ELISA format to test the hypothesis that inhibin B is the physiologically active form of inhibin in men. We measured and compared inhibin A, inhibin B, and pro-alpha-C-related immunoreactive peptides (pro-alpha-C-RI) in normal men before and after perturbations of their gonadotropin levels and baseline values in normal men and men with various disturbances of the hypothalamic- pituitary-testicular axis including men with idiopathic hypogonadotropic hypogonadism, infertile men with elevated FSH, men with Klinefelter's syndrome, and orchidectomized men. Mean serum inhibin concentrations were significantly higher in normal men than untreated men with idiopathic hypogonadotropic hypogonadism, infertile men with elevated FSH, untreated men with Klinefelter's syndrome, and orchidectomized men (187 +/- 28 vs 45 +/- 11, 37 +/- 6, 11 +/- 3, and < or = 10 pg/mL, respectively; P < 0.05). Inhibin B levels were below the limit of detection in all of the orchidectomized men. Pro-alpha-C-RI levels were detectable in all men studied including the orchidectomized men, and no significant differences in the pro-alpha-C-RI levels were noted between the normal men and men with various testicular diseases were noted except that orchidectomized men had significantly lower pro- alpha-C-RI levels than all other groups (P < 0.05). Inhibin A was undetectable in all men tested in this study. Six normal men who were administered exogenous levonorgestrel and testosterone had significantly lower serum gonadotropin, inhibin B, and pro-alpha-C-RI levels during the treatment period than the control and recovery periods (P < 0.05). Ten normal men who were administered human recombinant FSH had significantly higher peak serum FSH (21.85 +/- 3.23 IU/L vs. 3.01 +/- 0.51 IU/L), inhibin B (311 +/- 88 pg/mL vs. 151 +/- 23 pg/mL) and pro-alpha-C-RI (646 +/- 69 vs. 402 +/- 38 pg/mL) levels during the treatment period than the baseline values (P < 0.05). We conclude that inhibin B is a unique testicular product that is not detectable in the sera of orchidectomized men, is responsive to FSH stimulation, and has a reciprocal relationship with serum FSH levels in men with various forms of testicular disease. Therefore, inhibin B is likely to be the physiologically important form of inhibin in men.


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C. W. Martin, S. C. Riley, D. Everington, N. P. Groome, R. A. Riemersma, D. T. Baird, and R. A. Anderson
Dose-finding study of oral desogestrel with testosterone pellets for suppression of the pituitary-testicular axis in normal men
Hum. Reprod., July 1, 2000; 15(7): 1515 - 1524.
[Abstract] [Full Text] [PDF]


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Biol. Reprod.Home page
S. Ramaswamy, T. M. Plant, and G. R. Marshall
Pulsatile Stimulation with Recombinant Single Chain Human Luteinizing Hormone Elicits Precocious Sertoli Cell Proliferation in the Juvenile Male Rhesus Monkey (Macaca mulatta)
Biol Reprod, July 1, 2000; 63(1): 82 - 88.
[Abstract] [Full Text]


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EndocrinologyHome page
S. Ramaswamy, G. R. Marshall, A. S. McNeilly, and T. M. Plant
Dynamics of the Follicle-Stimulating Hormone (FSH)-Inhibin B Feedback Loop and Its Role in Regulating Spermatogenesis in the Adult Male Rhesus Monkey (Macaca mulatta) as Revealed by Unilateral Orchidectomy
Endocrinology, January 1, 2000; 141(1): 18 - 27.
[Abstract] [Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
K. Kubini, M. Zachmann, N. Albers, O. Hiort, M. Bettendorf, J. Wölfle, F. Bidlingmaier, and D. Klingmüller
Basal Inhibin B and the Testosterone Response to Human Chorionic Gonadotropin Correlate in Prepubertal Boys
J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 134 - 138.
[Abstract] [Full Text]


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Arch. Dis. Child.Home page
K L Ng, S F Ahmed, and I A Hughes
Pituitary-gonadal axis in male undermasculinisation
Arch. Dis. Child., January 1, 2000; 82(1): 54 - 58.
[Abstract] [Full Text]


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EndocrinologyHome page
S. J. Winters and T. M. Plant
Partial Characterization of Circulating Inhibin-B and Pro-{alpha}C During Development in the Male Rhesus Monkey
Endocrinology, December 1, 1999; 140(12): 5497 - 5504.
[Abstract] [Full Text]


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EndocrinologyHome page
N. Atanassova, C. McKinnell, M. Walker, K. J. Turner, J. S. Fisher, M. Morley, M. R. Millar, N. P. Groome, and R. M. Sharpe
Permanent Effects of Neonatal Estrogen Exposure in Rats on Reproductive Hormone Levels, Sertoli Cell Number, and the Efficiency of Spermatogenesis in Adulthood
Endocrinology, November 1, 1999; 140(11): 5364 - 5373.
[Abstract] [Full Text]


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J. Clin. Endocrinol. Metab.Home page
S. von Eckardstein, M. Simoni, M. Bergmann, G. F. Weinbauer, P. Gassner, A. G. Schepers, and E. Nieschlag
Serum Inhibin B in Combination with Serum Follicle-Stimulating Hormone (FSH) Is a More Sensitive Marker Than Serum FSH Alone for Impaired Spermatogenesis in Men, But Cannot Predict the Presence of Sperm in Testicular Tissue Samples
J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2496 - 2501.
[Abstract] [Full Text]


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J. Clin. Endocrinol. Metab.Home page
E. Carlsen, C. Olsson, J. H. Petersen, A.-M. Andersson, and N. E Skakkebæk
Diurnal Rhythm in Serum Levels of Inhibin B in Normal Men: Relation to Testicular Steroids and Gonadotropins
J. Clin. Endocrinol. Metab., May 1, 1999; 84(5): 1664 - 1669.
[Abstract] [Full Text]


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Hum ReprodHome page
C. Foresta, A. Bettella, M. Rossato, G. La Sala, M. De Paoli, and M. Plebani
Inhibin B plasma concentrations in oligozoospermic subjects before and after therapy with follicle stimulating hormone
Hum. Reprod., April 1, 1999; 14(4): 906 - 912.
[Abstract] [Full Text] [PDF]


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JCOHome page
P. M. Petersen, N. E. Skakkebak, K. Vistisen, M. Rorth, and A. Giwercman
Semen Quality and Reproductive Hormones Before Orchiectomy in Men With Testicular Cancer
J. Clin. Oncol., March 1, 1999; 17(3): 941 - 941.
[Abstract] [Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
P. M. Petersen, A.-M. Andersson, M. Rørth, G. Daugaard, and N. E. Skakkebæk
Undetectable Inhibin B Serum Levels in Men after Testicular Irradiation
J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 213 - 215.
[Abstract] [Full Text]


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Hum ReprodHome page
K. Steger, R. Rey, F. Louis, S. Kliesch, H.M. Behre, E. Nieschlag, W. Hoepffner, D. Bailey, A. Marks, and M. Bergmann
Reversion of the differentiated phenotype and maturation block in Sertoli cells in pathological human testis
Hum. Reprod., January 1, 1999; 14(1): 136 - 143.
[Abstract] [Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
G. Forti and C. Krausz
Evaluation and Treatment of the Infertile Couple
J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4177 - 4188.
[Full Text]


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J. Clin. Endocrinol. Metab.Home page
A.-M. Andersson, J. Müller, and N. E. Skakkebæk
Different Roles of Prepubertal and Postpubertal Germ Cells and Sertoli Cells in the Regulation of Serum Inhibin B Levels
J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4451 - 4458.
[Abstract] [Full Text]


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J. Clin. Endocrinol. Metab.Home page
F. H. Pierik, J. T. M. Vreeburg, T. Stijnen, F. H. de Jong, and R. F. A. Weber
Serum Inhibin B as a Marker of Spermatogenesis
J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3110 - 3114.
[Abstract] [Full Text]


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J. Clin. Endocrinol. Metab.Home page
W. Byrd, M. J. Bennett, B. R. Carr, Y. Dong, F. Wians, and W. Rainey
Regulation of Biologically Active Dimeric Inhibin A and B From Infancy to Adulthood in the Male
J. Clin. Endocrinol. Metab., August 1, 1998; 83(8): 2849 - 2854.
[Abstract] [Full Text]


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EndocrinologyHome page
S. Ramaswamy, C. R. Pohl, A. S. McNeilly, S. J. Winters, and T. M. Plant
The Time Course of Follicle-Stimulating Hormone Suppression by Recombinant Human Inhibin A in the Adult Male Rhesus Monkey (Macaca mulatta)
Endocrinology, August 1, 1998; 139(8): 3409 - 3415.
[Abstract] [Full Text] [PDF]


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Arch Intern MedHome page
C. M. Smyth and W. J. Bremner
Klinefelter Syndrome
Arch Intern Med, June 22, 1998; 158(12): 1309 - 1314.
[Abstract] [Full Text] [PDF]


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NEJMHome page
M. Phillip, J. E. Arbelle, Y. Segev, and R. Parvari
Male Hypogonadism Due to a Mutation in the Gene for the {beta}-Subunit of Follicle-Stimulating Hormone
N. Engl. J. Med., June 11, 1998; 338(24): 1729 - 1732.
[Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
F. J. Hayes, J. E. Hall, P. A. Boepple, and W. F. Crowley Jr.
Differential Control of Gonadotropin Secretion in the Human: Endocrine Role of Inhibin
J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 1835 - 1841.
[Full Text]


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EndocrinologyHome page
S. L. Fitzpatrick, D. M. Sindoni, P. J. Shughrue, M. V. Lane, I. J. Merchenthaler, and D. E. Frail
Expression of Growth Differentiation Factor-9 Messenger Ribonucleic Acid in Ovarian and Nonovarian Rodent and Human Tissues
Endocrinology, May 1, 1998; 139(5): 2571 - 2578.
[Abstract] [Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
Y. Zhengwei, N. G. Wreford, P. Royce, D. M. de Kretser, and R. I. McLachlan
Stereological Evaluation of Human Spermatogenesis after Suppression by Testosterone Treatment: Heterogeneous Pattern of Spermatogenic Impairment
J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1284 - 1291.
[Abstract] [Full Text]


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J. Clin. Endocrinol. Metab.Home page
C. Wang, N. G. Berman, J. D. Veldhuis, T. Der, V. McDonald, B. Steiner, and R. S. Swerdloff
Graded Testosterone Infusions Distinguish Gonadotropin Negative-Feedback Responsiveness in Asian and White Men--A Clinical Research Center Study
J. Clin. Endocrinol. Metab., March 1, 1998; 83(3): 870 - 876.
[Abstract] [Full Text]


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J. Clin. Endocrinol. Metab.Home page
S. L. Mellor, M. G. Richards, J. S. Pedersen, D. M. Robertson, and G. P. Risbridger
Loss of the Expression and Localization of Inhibin {alpha}-Subunit in High Grade Prostate Cancer
J. Clin. Endocrinol. Metab., March 1, 1998; 83(3): 969 - 975.
[Abstract] [Full Text]


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J. Clin. Endocrinol. Metab.Home page
A.-M. Andersson, J. Toppari, A.-M. Haavisto, J. H. Petersen, T. Simell, O. Simell, and N. E. Skakkebæk
Longitudinal Reproductive Hormone Profiles in Infants: Peak of Inhibin B Levels in Infant Boys Exceeds Levels in Adult Men
J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 675 - 681.
[Abstract] [Full Text]


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J. Clin. Endocrinol. Metab.Home page
A.-M. Andersson, A. Juul, J. H. Petersen, J. Muller, N. P. Groome, and N. E. Skakkebak
Serum Inhibin B in Healthy Pubertal and Adolescent Boys: Relation to Age, Stage of Puberty, and Follicle-Stimulating Hormone, Luteinizing Hormone, Testosterone, and Estradiol Levels
J. Clin. Endocrinol. Metab., December 1, 1997; 82(12): 3976 - 3981.
[Abstract] [Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
T. K. Jensen, A.-M. Andersson, N. H. I. Hjollund, T. Scheike, H. Kolstad, A. Giwercman, T. B. Henriksen, E. Ernst, J. P. Bonde, J. Olsen, et al.
Inhibin B as a Serum Marker of Spermatogenesis: Correlation to Differences in Sperm Concentration and Follicle-Stimulating Hormone Levels. A Study of 349 Danish Men
J. Clin. Endocrinol. Metab., December 1, 1997; 82(12): 4059 - 4063.
[Abstract] [Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
E. M. Wallace, N. P. Groome, S. C. Riley, A. C. Parker, and F. C. W. Wu
Effects of Chemotherapy-Induced Testicular Damage on Inhibin, Gonadotropin, and Testosterone Secretion: A Prospective Longitudinal Study
J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3111 - 3115.
[Abstract] [Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
T. M. Plant, V. Padmanabhan, S. Ramaswamy, D. S. McConnell, S. J. Winters, N. Groome, A. R. Midgley Jr., and A. S. McNeilly
Circulating Concentrations of Dimeric Inhibin A and B in the Male Rhesus Monkey (Macaca mulatta)
J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2617 - 2621.
[Abstract] [Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
C. K. Welt, K. A. Martin, A. E. Taylor, G. M. Lambert-Messerlian, W. F. Crowley Jr., J. A. Smith, D. A. Schoenfeld, and J. E. Hall
Frequency Modulation of Follicle-Stimulating Hormone (FSH) during the Luteal-Follicular Transition: Evidence for FSH Control of Inhibin B in Normal Women
J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2645 - 2652.
[Abstract] [Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
D. R. Mann, M. A. Akinbami, K. Wallen, K. G. Gould, N. P. Groome, I. Swanston, A. S. McNeilly, and H. M. Fraser
Inhibin-B in the Male Rhesus Monkey: Impact of Neonatal Gonadotropin-Releasing Hormone Antagonist Treatment and Sexual Development
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1928 - 1933.
[Abstract] [Full Text] [PDF]


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J. Clin. Endocrinol. Metab.Home page
P. Pigny, R. Desailloud, C. Cortet-Rudelli, A. Duhamel, D. Deroubaix-Allard, A. Racadot, and D. Dewailly
Serum {alpha}-Inhibin Levels in Polycystic Ovary Syndrome: Relationship to the Serum Androstenedione Level
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1939 - 1943.
[Abstract] [Full Text] [PDF]


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EndocrinologyHome page
H. G. Burger and D. M. Robertson
Editorial: Inhibin in the Male--Progress at Last
Endocrinology, April 1, 1997; 138(4): 1361 - 1362.
[Full Text] [PDF]


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EndocrinologyHome page
S. S. Majumdar, S. J. Winters, and T. M. Plant
A Study of the Relative Roles of Follicle-Stimulating Hormone and Luteinizing Hormone in the Regulation of Testicular Inhibin Secretion in the Rhesus Monkey (Macaca mulatta)
Endocrinology, April 1, 1997; 138(4): 1363 - 1373.
[Abstract] [Full Text] [PDF]




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