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Journal of Clinical Endocrinology & Metabolism, Vol 81, 3123-3126, Copyright © 1996 by Endocrine Society

ARTICLES

Vitamin A and retinoic acid stimulate within minutes cAMP release and growth hormone secretion in human pituitary cells

C Djakoure, J Guibourdenche, D Porquet, P Pagesy, F Peillon, JY Li and D Evain- Brion
Unite INSERM 223, Faculte de Medecine Pitie-Salpetriere, Paris.

In order to gain a better understanding on the possible role of vitamin A (VA) and retinoic acid (RA) on human growth hormone (GH) secretion, we used the physiological model of pituitary cells perifusion. In perifused cells from pituitary somatotropic adenomas, RA induced within minutes a peak of GH secretion. This effect was dose dependent, maximal effect being observed with 100 nM. The GH release was associated with a discharge of cAMP delayed by 4 to 8 minutes relative to the GH surge. Similar results were obtained after VA stimulation. Our observations provide the first evidence of an action of VA and RA on cAMP production. They suggest a role of RA and VA in the regulation of human GH secretion via the cAMP dependent pathway.


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