help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iwahashi, M.
Right arrow Articles by Nakano, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iwahashi, M.
Right arrow Articles by Nakano, R.

Journal of Clinical Endocrinology & Metabolism, Vol 81, 2925-2929, Copyright © 1996 by Endocrine Society

ARTICLES

Decreased type IV collagen expression by human decidual tissues in spontaneous abortion

M Iwahashi, Y Muragaki, A Ooshima and R Nakano
Department of Obstetrics and Gynecology, Wakayama Medical College, Japan.

To provide some insight into the etiology of spontaneous abortion, the expression of type IV collagen was investigated in human decidual tissues obtained after spontaneous abortion (n = 17) and normal pregnancy (n = 22). Indirect immunofluorescent staining was performed for type I, III, and IV collagen as well as laminin, and Northern blot analysis was conducted to assess the expression of messenger ribonucleic acid for the alpha 1(IV) chain. Immunohistochemical analysis did not reveal any significant differences between normal pregnancy and spontaneous abortion with respect to interstitial collagens (type I and III collagen) and laminin in the decidual tissue. However, although pericellular immunostaining for type IV collagen was recognized around the decidual cells in normal pregnancy, very weak or no staining was observed in spontaneous abortion. Northern blot analysis revealed that the decidual expression of messenger ribonucleic acid for the alpha 1(IV) chain was significantly reduced in spontaneous abortion compared to that in normal pregnancy (P < 0.001). These results suggest that type IV collagen might play an important role in the maintenance of pregnancy and that decreased expression of this collagen could be associated with spontaneous abortion.


This article has been cited by other articles:


Home page
 Mol Hum ReprodHome page
V. Jokimaa, S. Oksjoki, H. Kujari, E. Vuorio, and L. Anttila
Altered expression of genes involved in the production and degradation of endometrial extracellular matrix in patients with unexplained infertility and recurrent miscarriages
Mol. Hum. Reprod., December 1, 2002; 8(12): 1111 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
N. Sugino, M. Nakata, S. Kashida, A. Karube, S. Takiguchi, and H. Kato
Decreased superoxide dismutase expression and increased concentrations of lipid peroxide and prostaglandin F2{alpha} in the decidua of failed pregnancy
Mol. Hum. Reprod., July 1, 2000; 6(7): 642 - 647.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1996 by The Endocrine Society