| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 81, 2908-2911, Copyright © 1996 by Endocrine Society
ARTICLES |
H Laivuori, MJ Tikkanen and O Ylikorkala
Department of Obstetrics and Gynecology, University Central Hospital of Helsinki, Finland.
Insulin resistance syndrome predisposes to occlusive vascular disorders in nonpregnant subjects. Because preeclampsia, representing a pregnancy- specific occlusive vascular disorder, is known to be accompanied by metabolic changes similar to those in insulin resistance syndrome, we compared carbohydrate and lipid metabolism in 22 women who had a preeclamptic first pregnancy and in 22 control women who had normotensive first pregnancy, both, on the average, 17.0 +/- 0.7 yr earlier. The study groups were comparable in regard to body mass index at the follow-up study. Women with prior preeclampsia were normoglycemic (baseline, 3 h oral glucose tolerance), but showed a significant hyperinsulinemia, as seen from elevated immunoreactive insulin (IRI) levels at the baseline (mean +/- SE, 7.3 +/- 0.6 vs. 5.5 +/- 0.5 mU/L; P < 0.03), after 1 h (45.7 +/- 5.5 vs. 35.6 +/- 3.5 mU/L; P = 0.13), after 2 h (32.4 +/- 4.1 vs. 23.8 +/- 2.3 mU/L; P = 0.08), and after 3 h (10.1 +/- 1.4 vs. 6.4 +/- 0.6 mU/L; P = 0.02). The area under the IRI curve was larger in the women with prior preeclampsia (86.8 +/- 9.1 vs. 65.4 +/- 5.2 mU/h.L; P = 0.05). The serum levels of total cholesterol, high density lipoprotein (HDL) cholesterol (with its subfractions HDL2 and HDL3), low density lipoprotein cholesterol, triglyceride, or uric acid did not differ significantly between the study groups. In women with prior preeclamsia, the area under the IRI curve was negatively related to HDL2 cholesterol, but positively related to triglyceride and systolic blood pressure. We conclude that a history of preeclampsia is associated with mild hyperinsulinemia in nonpregnant women.
This article has been cited by other articles:
 |
|
 |
|
  J. A. Lykke, J. Langhoff-Roos, B. M. Sibai, E. F. Funai, E. W. Triche, and M. J. Paidas Hypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother Hypertension, June 1, 2009; 53(6): 944 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kajantie, J. G. Eriksson, C. Osmond, K. Thornburg, and D. J.P. Barker Pre-Eclampsia Is Associated With Increased Risk of Stroke in the Adult Offspring: The Helsinki Birth Cohort Study Stroke, April 1, 2009; 40(4): 1176 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Berends, C. J.M. de Groot, E. J. Sijbrands, M. P.S. Sie, S. H. Benneheij, R. Pal, R. Heydanus, B. A. Oostra, C. M. van Duijn, and E. A.P. Steegers Shared Constitutional Risks for Maternal Vascular-Related Pregnancy Complications and Future Cardiovascular Disease Hypertension, April 1, 2008; 51(4): 1034 - 1041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J Kaaja Metabolic syndrome and the menopause Menopause Int, March 1, 2008; 14(1): 21 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Girouard, Y. Giguere, J.-M. Moutquin, and J.-C. Forest Previous Hypertensive Disease of Pregnancy Is Associated With Alterations of Markers of Insulin Resistance Hypertension, May 1, 2007; 49(5): 1056 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Paradisi, A. Biaggi, R. Savone, F. Ianniello, C. Tomei, L. Caforio, and A. Caruso Cardiovascular Risk Factors in Healthy Women with Previous Gestational Hypertension J. Clin. Endocrinol. Metab., April 1, 2006; 91(4): 1233 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Roberts and H. Gammill Insulin Resistance in Preeclampsia Hypertension, March 1, 2006; 47(3): 341 - 342. [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Kaaja and I. A. Greer Manifestations of Chronic Disease During Pregnancy JAMA, December 7, 2005; 294(21): 2751 - 2757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kajantie, R. Kaaja, O. Ylikorkala, S. Andersson, and H. Laivouri Adiponectin Concentrations in Maternal Serum: Elevated in Preeclampsis But Unrelated to Insulin Sensitivity Reproductive Sciences, September 1, 2005; 12(6): 433 - 439. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Kaaja, T. Kinnunen, and R. Luoto Regional differences in the prevalence of pre-eclampsia in relation to the risk factors for coronary artery disease in women in Finland Eur. Heart J., January 1, 2005; 26(1): 44 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wolf, C. A. Hubel, C. Lam, M. Sampson, J. L. Ecker, R. B. Ness, A. Rajakumar, A. Daftary, A. S. M. Shakir, E. W. Seely, et al. Preeclampsia and Future Cardiovascular Disease: Potential Role of Altered Angiogenesis and Insulin Resistance J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6239 - 6243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pouta, A.-L. Hartikainen, U. Sovio, M. Gissler, J. Laitinen, M. I. McCarthy, A. Ruokonen, P. Elliott, and M.-R. Jarvelin Manifestations of Metabolic Syndrome After Hypertensive Pregnancy Hypertension, April 1, 2004; 43(4): 825 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sattar, J. Ramsay, L. Crawford, H. Cheyne, and I. A. Greer Classic and Novel Risk Factor Parameters in Women With a History of Preeclampsia Hypertension, July 1, 2003; 42(1): 39 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W. Seely and C. G. Solomon Insulin Resistance and Its Potential Role in Pregnancy-Induced Hypertension J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2393 - 2398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Roberts, G. Pearson, J. Cutler, and M. Lindheimer Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy Hypertension, March 1, 2003; 41(3): 437 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sattar and I. A Greer Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening? BMJ, July 20, 2002; 325(7356): 157 - 160. [Full Text] [PDF]
|
|
|
|
|
|
K. Y. Lain and J. M. Roberts Contemporary Concepts of the Pathogenesis and Management of Preeclampsia JAMA, June 26, 2002; 287(24): 3183 - 3186. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tiitinen Obstetric outcome in women with polycystic ovarian syndrome Hum. Reprod., July 1, 2001; 16(7): 1537 - 1537. [Full Text] [PDF]
|
|
|
|
|
|
M. Mikola, V. Hiilesmaa, M. Halttunen, L. Suhonen, and A. Tiitinen Obstetric outcome in women with polycystic ovarian syndrome Hum. Reprod., February 1, 2001; 16(2): 226 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Solomon and E. W. Seely Brief Review: Hypertension in Pregnancy : A Manifestation of the Insulin Resistance Syndrome? Hypertension, February 1, 2001; 37(2): 232 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W. Seely Hypertension in Pregnancy: A Potential Window into Long-Term Cardiovascular Risk in Women J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 1858 - 1861. [Full Text]
|
|
|
|
|
|
J. Holte, G. Gennarelli, L. Wide, H. Lithell, and C. Berne High Prevalence of Polycystic Ovaries and Associated Clinical, Endocrine, and Metabolic Features in Women with Previous Gestational Diabetes Mellitus J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1143 - 1150. [Abstract] [Full Text]
|
|
|
|
|
|
H. Laivuori, R. Kaaja, E.-M. Rutanen, L. Viinikka, and O. Ylikorkala Evidence of High Circulating Testosterone in Women with Prior Preeclampsia J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 344 - 347. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
