help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laivuori, H.
Right arrow Articles by Ylikorkala, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laivuori, H.
Right arrow Articles by Ylikorkala, O.

Journal of Clinical Endocrinology & Metabolism, Vol 81, 2908-2911, Copyright © 1996 by Endocrine Society

ARTICLES

Hyperinsulinemia 17 years after preeclamptic first pregnancy

H Laivuori, MJ Tikkanen and O Ylikorkala
Department of Obstetrics and Gynecology, University Central Hospital of Helsinki, Finland.

Insulin resistance syndrome predisposes to occlusive vascular disorders in nonpregnant subjects. Because preeclampsia, representing a pregnancy- specific occlusive vascular disorder, is known to be accompanied by metabolic changes similar to those in insulin resistance syndrome, we compared carbohydrate and lipid metabolism in 22 women who had a preeclamptic first pregnancy and in 22 control women who had normotensive first pregnancy, both, on the average, 17.0 +/- 0.7 yr earlier. The study groups were comparable in regard to body mass index at the follow-up study. Women with prior preeclampsia were normoglycemic (baseline, 3 h oral glucose tolerance), but showed a significant hyperinsulinemia, as seen from elevated immunoreactive insulin (IRI) levels at the baseline (mean +/- SE, 7.3 +/- 0.6 vs. 5.5 +/- 0.5 mU/L; P < 0.03), after 1 h (45.7 +/- 5.5 vs. 35.6 +/- 3.5 mU/L; P = 0.13), after 2 h (32.4 +/- 4.1 vs. 23.8 +/- 2.3 mU/L; P = 0.08), and after 3 h (10.1 +/- 1.4 vs. 6.4 +/- 0.6 mU/L; P = 0.02). The area under the IRI curve was larger in the women with prior preeclampsia (86.8 +/- 9.1 vs. 65.4 +/- 5.2 mU/h.L; P = 0.05). The serum levels of total cholesterol, high density lipoprotein (HDL) cholesterol (with its subfractions HDL2 and HDL3), low density lipoprotein cholesterol, triglyceride, or uric acid did not differ significantly between the study groups. In women with prior preeclamsia, the area under the IRI curve was negatively related to HDL2 cholesterol, but positively related to triglyceride and systolic blood pressure. We conclude that a history of preeclampsia is associated with mild hyperinsulinemia in nonpregnant women.


This article has been cited by other articles:


Home page
 HypertensionHome page
A. L. Berends, C. J.M. de Groot, E. J. Sijbrands, M. P.S. Sie, S. H. Benneheij, R. Pal, R. Heydanus, B. A. Oostra, C. M. van Duijn, and E. A.P. Steegers
Shared Constitutional Risks for Maternal Vascular-Related Pregnancy Complications and Future Cardiovascular Disease
Hypertension, April 1, 2008; 51(4): 1034 - 1041.
[Abstract] [Full Text] [PDF]

Home page
 Menopause IntHome page
R. J Kaaja
Metabolic syndrome and the menopause
Menopause Int, March 1, 2008; 14(1): 21 - 25.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. Girouard, Y. Giguere, J.-M. Moutquin, and J.-C. Forest
Previous Hypertensive Disease of Pregnancy Is Associated With Alterations of Markers of Insulin Resistance
Hypertension, May 1, 2007; 49(5): 1056 - 1062.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Paradisi, A. Biaggi, R. Savone, F. Ianniello, C. Tomei, L. Caforio, and A. Caruso
Cardiovascular Risk Factors in Healthy Women with Previous Gestational Hypertension
J. Clin. Endocrinol. Metab., April 1, 2006; 91(4): 1233 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. M. Roberts and H. Gammill
Insulin Resistance in Preeclampsia
Hypertension, March 1, 2006; 47(3): 341 - 342.
[Full Text] [PDF]

Home page
 JAMAHome page
R. J. Kaaja and I. A. Greer
Manifestations of Chronic Disease During Pregnancy
JAMA, December 7, 2005; 294(21): 2751 - 2757.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
E. Kajantie, R. Kaaja, O. Ylikorkala, S. Andersson, and H. Laivouri
Adiponectin Concentrations in Maternal Serum: Elevated in Preeclampsis But Unrelated to Insulin Sensitivity
Reproductive Sciences, September 1, 2005; 12(6): 433 - 439.
[Abstract] [PDF]

Home page
 Obstet GynecolHome page
J.-C. Forest, J. Girouard, J. Masse, J.-M. Moutquin, A. Kharfi, R. B. Ness, J. M. Roberts, and Y. Giguere
Early Occurrence of Metabolic Syndrome After Hypertension in Pregnancy
Obstet. Gynecol., June 1, 2005; 105(6): 1373 - 1380.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
R. Kaaja, T. Kinnunen, and R. Luoto
Regional differences in the prevalence of pre-eclampsia in relation to the risk factors for coronary artery disease in women in Finland
Eur. Heart J., January 1, 2005; 26(1): 44 - 50.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Wolf, C. A. Hubel, C. Lam, M. Sampson, J. L. Ecker, R. B. Ness, A. Rajakumar, A. Daftary, A. S. M. Shakir, E. W. Seely, et al.
Preeclampsia and Future Cardiovascular Disease: Potential Role of Altered Angiogenesis and Insulin Resistance
J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6239 - 6243.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Pouta, A.-L. Hartikainen, U. Sovio, M. Gissler, J. Laitinen, M. I. McCarthy, A. Ruokonen, P. Elliott, and M.-R. Jarvelin
Manifestations of Metabolic Syndrome After Hypertensive Pregnancy
Hypertension, April 1, 2004; 43(4): 825 - 831.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
N. Sattar, J. Ramsay, L. Crawford, H. Cheyne, and I. A. Greer
Classic and Novel Risk Factor Parameters in Women With a History of Preeclampsia
Hypertension, July 1, 2003; 42(1): 39 - 42.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. W. Seely and C. G. Solomon
Insulin Resistance and Its Potential Role in Pregnancy-Induced Hypertension
J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2393 - 2398.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. M. Roberts, G. Pearson, J. Cutler, and M. Lindheimer
Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy
Hypertension, March 1, 2003; 41(3): 437 - 445.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
N. Sattar and I. A Greer
Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening?
BMJ, July 20, 2002; 325(7356): 157 - 160.
[Full Text] [PDF]

Home page
 JAMAHome page
K. Y. Lain and J. M. Roberts
Contemporary Concepts of the Pathogenesis and Management of Preeclampsia
JAMA, June 26, 2002; 287(24): 3183 - 3186.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Tiitinen
Obstetric outcome in women with polycystic ovarian syndrome
Hum. Reprod., July 1, 2001; 16(7): 1537 - 1537.
[Full Text] [PDF]

Home page
 Obstet GynecolHome page
K. E. INNES, J. H. WIMSATT, and R. MCDUFFIE
Relative Glucose Tolerance and Subsequent Development of Hypertension in Pregnancy
Obstet. Gynecol., June 1, 2001; 97(6): 905 - 910.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
W. A. GROBMAN and R. R. KAZER
Serum Insulin, Insulin-Like Growth Factor-I, and Insulin-Like Growth Factor Binding Protein-1 in Women Who Develop Preeclampsia
Obstet. Gynecol., April 1, 2001; 97(4): 521 - 526.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Mikola, V. Hiilesmaa, M. Halttunen, L. Suhonen, and A. Tiitinen
Obstetric outcome in women with polycystic ovarian syndrome
Hum. Reprod., February 1, 2001; 16(2): 226 - 229.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. G. Solomon and E. W. Seely
Brief Review: Hypertension in Pregnancy : A Manifestation of the Insulin Resistance Syndrome?
Hypertension, February 1, 2001; 37(2): 232 - 239.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
R. HIETALA, P. POHJA-NYLANDER, E.-M. RUTANEN, and T. LAATIKAINEN
Serum Insulin-Like Growth Factor Binding Protein-1 at 16 Weeks and Subsequent Preeclampsia
Obstet. Gynecol., February 1, 2000; 95(2): 185 - 189.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
R. THADHANI, M. J. STAMPFER, D. J. HUNTER, J. E. MANSON, C. G. SOLOMON, and G. C. CURHAN
High Body Mass Index and Hypercholesterolemia: Risk of Hypertensive Disorders of Pregnancy
Obstet. Gynecol., October 1, 1999; 94(4): 543 - 550.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. W. Seely
Hypertension in Pregnancy: A Potential Window into Long-Term Cardiovascular Risk in Women
J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 1858 - 1861.
[Full Text]

Home page
 Obstet GynecolHome page
H. LAIVUORI, R. KAAJA, U. TURPEINEN, L. VIINIKKA, and O. YLIKORKALA
Plasma Homocysteine Levels Elevated and Inversely Related to Insulin Sensitivity in Preeclampsia
Obstet. Gynecol., April 1, 1999; 93(4): 489 - 493.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Holte, G. Gennarelli, L. Wide, H. Lithell, and C. Berne
High Prevalence of Polycystic Ovaries and Associated Clinical, Endocrine, and Metabolic Features in Women with Previous Gestational Diabetes Mellitus
J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1143 - 1150.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. Laivuori, R. Kaaja, E.-M. Rutanen, L. Viinikka, and O. Ylikorkala
Evidence of High Circulating Testosterone in Women with Prior Preeclampsia
J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 344 - 347.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1996 by The Endocrine Society