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Journal of Clinical Endocrinology & Metabolism, Vol 81, 2738-2741, Copyright © 1996 by Endocrine Society
ARTICLES |
JE Pabon, JS Bird, X Li, ZH Huang, ZM Lei, JS Sanfilippo, MA Yussman and CV Rao
Department of Obstetrics and Gynecology, University of Louisville Medical Center, KY 40292, USA.
Normal human skin contains a major 4.5 kb and several minor mRNA transcripts and a 66 kDa protein of luteinizing hormone (LH)/chorionic gonadotropin (hCG) receptors which are capable of binding exogenous 125I-hCG. The distribution of receptor transcripts and receptor protein are the highest in epidermis followed by hair follicles, sebaceous and sweat glands. LH/hCG receptors are co-localized with androgen receptors in all the skin appendages. These data are the first demonstration of skin containing LH/hCG receptors and would suggest that LH and hCG may regulate skin functions.
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