help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pfeilschifter, J.
Right arrow Articles by Ziegler, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pfeilschifter, J.
Right arrow Articles by Ziegler, R.

Journal of Clinical Endocrinology & Metabolism, Vol 81, 2534-2540, Copyright © 1996 by Endocrine Society

ARTICLES

Relationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50- to 80-year-old men and women

J Pfeilschifter, C Scheidt-Nave, G Leidig-Bruckner, HW Woitge, WF Blum, C Wuster, D Haack and R Ziegler
Department of Internal Medicine, University of Heidelberg, Germany.

There is a large body of evidence that points to a systemic link between the somatotropic axis and sex hormones, but epidemiologic data on the interactions between the two hormonal systems are still missing. We examined here the associations between the plasma levels of insulin- like growth factor (IGF) I, IGF-II, IGF-binding protein 3 (IGFBP-3), and sex hormones in a population-based sample of 486 men and women, aged 50-80 yr. The strongest association was an age-independent inverse correlation between all three circulating IGF components and sex hormone-binding globulin (SHBG), the major testosterone-binding protein in plasma. Consistent with this, bio-available (non-SHBG-bound) but not total testosterone levels were positively associated with the IGF system in men, and 3 alpha-androstanediol glucuronide was positively correlated with circulating IGFs in women. Moreover, part of the correlation between the circulating IGF system and bone mineral density at the femur and the calcaneus could be accounted for by SHBG. Our data suggest that sex hormones and the GH/IGF system are significantly interrelated in the elderly population. These hormonal interactions may play an important role in human aging and the pathogenesis of age- related diseases.


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
S. Khosla, S. Amin, and E. Orwoll
Osteoporosis in Men
Endocr. Rev., June 1, 2008; 29(4): 441 - 464.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. Hsu and C. A. Feghali-Bostwick
Insulin-Like Growth Factor-II Is Increased in Systemic Sclerosis-Associated Pulmonary Fibrosis and Contributes to the Fibrotic Process via Jun N-Terminal Kinase- and Phosphatidylinositol-3 Kinase-Dependent Pathways
Am. J. Pathol., June 1, 2008; 172(6): 1580 - 1590.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
A. A van der Klaauw, N. R Biermasz, P. M J Zelissen, A. M Pereira, E. G W M Lentjes, J. W A Smit, S. W van Thiel, J. A Romijn, and F. Roelfsema
Administration route-dependent effects of estrogens on IGF-I levels during fixed GH replacement in women with hypopituitarism
Eur. J. Endocrinol., December 1, 2007; 157(6): 709 - 716.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
S. Forsmo, J. Aaen, B. Schei, and A. Langhammer
What Is the Influence of Weight Change on Forearm Bone Mineral Density in Peri- and Postmenopausal Women? The Health Study of Nord-Trondelag, Norway
Am. J. Epidemiol., November 1, 2006; 164(9): 890 - 897.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. M. Kaufman and A. Vermeulen
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Endocr. Rev., October 1, 2005; 26(6): 833 - 876.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. L. Davison, R. Bell, S. Donath, J. G. Montalto, and S. R. Davis
Androgen Levels in Adult Females: Changes with Age, Menopause, and Oophorectomy
J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 3847 - 3853.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
R. Eastell
Role of oestrogen in the regulation of bone turnover at the menarche
J. Endocrinol., May 1, 2005; 185(2): 223 - 234.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. W. Goderie-Plomp, M. van der Klift, W. de Ronde, A. Hofman, F. H. de Jong, and H. A. P. Pols
Endogenous Sex Hormones, Sex Hormone-Binding Globulin, and the Risk of Incident Vertebral Fractures in Elderly Men and Women: The Rotterdam Study
J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3261 - 3269.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Decensi, B. Bonanni, L. Baglietto, A. Guerrieri-Gonzaga, F. Ramazzotto, H. Johansson, C. Robertson, I. Marinucci, F. Mariette, M. T. Sandri, et al.
A Two-by-Two Factorial Trial Comparing Oral with Transdermal Estrogen Therapy and Fenretinide with Placebo on Breast Cancer Biomarkers
Clin. Cancer Res., July 1, 2004; 10(13): 4389 - 4397.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Rivadeneira, J. J. Houwing-Duistermaat, N. Vaessen, J. M. Vergeer-Drop, A. Hofman, H. A. P. Pols, C. M. van Duijn, and A. G. Uitterlinden
Association between an Insulin-Like Growth Factor I Gene Promoter Polymorphism and Bone Mineral Density in the Elderly: The Rotterdam Study
J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3878 - 3884.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
L. Cordain, S. Lindeberg, M. Hurtado, K. Hill, S. B. Eaton, and J. Brand-Miller
Acne Vulgaris: A Disease of Western Civilization
Arch Dermatol, December 1, 2002; 138(12): 1584 - 1590.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
C. Christmas, K. G. O'Connor, S. M. Harman, J. D. Tobin, T. Munzer, M. F. Bellantoni, C. St. Clair, K. M. Pabst, J. D. Sorkin, and M. R. Blackman
Growth Hormone and Sex Steroid Effects on Bone Metabolism and Bone Mineral Density in Healthy Aged Women and Men
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2002; 57(1): M12 - 18.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Vermeulen
Androgen Replacement Therapy in the Aging Male--A Critical Evaluation
J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2380 - 2390.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Scheidt-Nave, H. Bismar, G. Leidig-Bruckner, H. Woitge, M. J. Seibel, R. Ziegler, and J. Pfeilschifter
Serum Interleukin 6 Is a Major Predictor of Bone Loss in Women Specific to the First Decade Past Menopause
J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 2032 - 2042.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. M. Erfurth, B. Bülow, Z. Mikoczy, and L. Hagmar
Incidence of a Second Tumor in Hypopituitary Patients Operated for Pituitary Tumors
J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 659 - 662.
[Abstract] [Full Text]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
G. Ravaglia, P. Forti, F. Maioli, B. Nesi, L. Pratelli, D. Cucinotta, L. Bastagli, and G. Cavalli
Body Composition, Sex Steroids, IGF-1, and Bone Mineral Status in Aging Men
J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2000; 55(9): 516M - 521.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. A. Laughlin, E. Barrett-Connor, D. Kritz-Silverstein, and D. von Mühlen
Hysterectomy, Oophorectomy, and Endogenous Sex Hormone Levels in Older Women: The Rancho Bernardo Study
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 645 - 651.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. R. Center, T. V. Nguyen, P. N. Sambrook, and J. A. Eisman
Hormonal and Biochemical Parameters in the Determination of Osteoporosis in Elderly Men
J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3626 - 3635.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Vestergaard, A. P. Hermann, H. Ørskov, and L. Mosekilde
Effect of Sex Hormone Replacement on the Insulin-Like Growth Factor System and Bone Mineral: A Cross-Sectional and Longitudinal Study in 595 Perimenopausal Women Participating in the Danish Osteoporosis Prevention Study
J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2286 - 2290.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. A. Langlois, C. J. Rosen, M. Visser, M. T. Hannan, T. Harris, P. W. F. Wilson, and D. P. Kiel
Association Between Insulin-Like Growth Factor I and Bone Mineral Density in Older Women and Men: The Framingham Heart Study
J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4257 - 4262.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Seck, B. Scheppach, S. Scharla, I. Diel, W. F. Blum, H. Bismar, G. Schmid, B. Krempien, R. Ziegler, and J. Pfeilschifter
Concentration of Insulin-Like Growth Factor (IGF)-I and -II in Iliac Crest Bone Matrix from Pre- and Postmenopausal Women: Relationship to Age, Menopause, Bone Turnover, Bone Volume, and Circulating IGFs
J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2331 - 2337.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. S. Kurland, C. J. Rosen, F. Cosman, D. McMahon, F. Chan, E. Shane, R. Lindsay, D. Dempster, and J. P. Bilezikian
Insulin-Like Growth Factor-I in Men with Idiopathic Osteoporosis
J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 2799 - 2805.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Young, B. Couzinet, K. Nahoul, S. Brailly, P. Chanson, E. E. Baulieu, and G. Schaison
Panhypopituitarism as a Model to Study the Metabolism of Dehydroepiandrosterone (DHEA) in Humans
J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2578 - 2585.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1996 by The Endocrine Society