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Journal of Clinical Endocrinology & Metabolism, Vol 81, 2335-2337, Copyright © 1996 by Endocrine Society

ARTICLES

Ouabain is a potent inhibitor of aldosterone secretion and angiotensin action in the human adrenal

I Antonipillai, K Schick and R Horton
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.

Digitalis glycosides and a putative ouabain-like substance act by inhibiting Na,K-adenosine triphosphatases and could regulate aldosterone secretion. We studied the effects of ouabain on basal and angiotensin II (AII)-induced aldosterone in rat and human adrenal glomerulosa cells. In the rat, ouabain at doses as high as 10(-4) mol/L had no effect on basal aldosterone secretion, but caused a dose-related inhibition of AII and ACTH secretion. In human glomerulosa cells, ouabain was 1000 times more potent on both basal and AII stimulation, with action at 10(-8) mol/L. The effect of ACTH was also blunted by 10(- 8)-10(-7) mol/L ouabain. However, the effect of potassium (8.7 mmol/L) on aldosterone was not altered by these doses of ouabain. These results suggest that nanomolar levels of ouabain can reduce aldosterone secretion from human zona glomerulosa cells.


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