help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Santini, L.
Right arrow Articles by Colantuoni, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Santini, L.
Right arrow Articles by Colantuoni, V.

Journal of Clinical Endocrinology & Metabolism, Vol 81, 1784-1786, Copyright © 1996 by Endocrine Society

ARTICLES

A primary, lateral-cervical medullary thyroid carcinoma: a case report

L Santini, C Scurini, C Caraco, G Conzo, P Orabona, G De Rosa, O Fattoruso and V Colantuoni
Istituto di Semeiotica Chirurgica, Facolta di Medicina, Seconda Universita degli Studi di Napoli, Italy.

Medullary thyroid carcinoma (MTC) arises from the parafollicular cells of the thyroid and occurs in a sporadic or in an inherited form. We present a case of an aberrant MTC in a patient with a functioning thyroid gland. At surgical dissection, the thyroid was present in its anatomical site with a nodule in the upper one third of the right lobe. A mass was also found in a lateral-cervical position distinct from the thyroid gland. Histological examination showed the mass to be the primary MTC, whereas the thyroid nodule was a follicular adenoma. Analysis of DNA extracted from the MTC, from the adenoma, and from peripheral blood revealed a mutation within exon 16 of the RET proto- oncogene only in the DNA from the tumor. The reported case represents a sporadic MTC in an aberrant localization, probably originating from a developmental abnormality of the primordial C cells. This event might have occurred during the migration and/or differentiation of the C cells and might be related to, or caused by, the mutated RET proto- oncogene.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
L. Santini, C. Scurini, C. Caracò, G. Gonzo, P. Orabona, G. deRosa, O. Fattoruso, and V. Colantuoni
Thyroid Medullary Carcinoma Occurring Laterally in the Neck--Author's Response
J. Clin. Endocrinol. Metab., March 1, 1997; 82(3): 984 - 984.
[Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. R. Harach and E. D. Williams
Thyroid Medullary Carcinoma Occurring Laterally in the Neck
J. Clin. Endocrinol. Metab., March 1, 1997; 82(3): 983a - 984.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1996 by The Endocrine Society