help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldman, M. B.
Right arrow Articles by Hedeker, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldman, M. B.
Right arrow Articles by Hedeker, D.

Journal of Clinical Endocrinology & Metabolism, Vol 81, 1465-1470, Copyright © 1996 by Endocrine Society

ARTICLES

The influence of polydipsia on water excretion in hyponatremic, polydipsic, schizophrenic patients

MB Goldman, GL Robertson, DJ Luchins and D Hedeker
University of Chicago Pritzker School of Medicine, Illinois 60637, USA.

To determine whether polydipsia is responsible for the altered water excretion in the subset of polydipsic schizophrenic patients who develop hyponatremia, the regulation of antidiuretic function was assessed in polydipsic schizophrenic patients with hyponatremia (n = 5), polydipsic schizophrenic patients without hyponatremia (n = 5), nonpolydipsic schizophrenic patients (n = 6), and normal controls (n = 8). The severity and duration of polyuria were similar in the two polydipsic groups. After oral water loading, maximal free water clearance was similar across all four groups. Free water clearance diminished, however, at lower plasma osmolalities in the hyponatremic polydipsics (P < 0.02) and at higher plasma osmolalities in the normonatremic polydipsics (P < 0.05) relative to that in the nonpolydipsic schizophrenics and normal subjects. The increase in plasma vasopressin after osmotic stimulation with hypertonic saline was slightly, but significantly (P < 0.02), blunted in both polydipsic groups. Hyponatremia occurs in some polydipsic schizophrenics because the relationship between free water clearance to plasma osmolality/sodium is shifted to the left. Polydipsia per se is not responsible for this still unexplained shift.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
M. B. Goldman, G. Wood, M. B. Goldman, M. Gavin, S. Paul, S. Zaheer, G. Fayyaz, and R. S. Pilla
Diminished Glucocorticoid Negative Feedback in Polydipsic Hyponatremic Schizophrenic Patients
J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 698 - 704.
[Abstract] [Full Text] [PDF]

Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
C. M. Canuso and M. B. Goldman
Clozapine Restores Water Balance in Schizophrenic Patients With Polydipsia-Hyponatremia Syndrome
J Neuropsychiatry Clin Neurosci, February 1, 1999; 11(1): 86 - 90.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1996 by The Endocrine Society