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Journal of Clinical Endocrinology & Metabolism, Vol 81, 4484-4487, Copyright © 1996 by Endocrine Society

ARTICLES

Development of acromegaly during treatment of hyperprolactinemia with bromocriptine: an unusual acidophil stem cell adenoma

MD Page, LR Bridges, JH Barth, AM McNichol and PE Belchetz
Department of Endocrinology, General Infirmary, Leeds, United Kingdom.

We present clinical details of a patient with a 20-yr history of amennorhea, a pituitary tumor, elevated PRL levels, and initially undetectable GH. Bromocriptine failed to fully suppress PRL, and there was no tumor shrinkage. Within 7 months of starting bromocriptine treatment, the patient developed clinical and biochemical signs of acromegaly. At surgery, a stem cell adenoma was excised. The mechanisms by which bromocriptine may have resulted in the development of acromegaly in this patient are discussed.




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Copyright © 1996 by The Endocrine Society