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Journal of Clinical Endocrinology & Metabolism, Vol 81, 4310-4312, Copyright © 1996 by Endocrine Society

ARTICLES

Aldosterone-producing adenomas do not contain glucocorticoid-remediable aldosteronism chimeric gene duplications

J Carroll, R Dluhy, F Fallo, M Pistorello, G Bradwin, CE Gomez-Sanchez and R Mortensen
Endocrine Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

In glucocorticoid-remediable aldosteronism (GRA) a chimeric gene has been described with the activity of aldosterone synthase, but the promoter of 11 beta-hydroxylase leading to ectopic expression of aldosterone synthase activity in the zona fasciculata. Similar to GRA, in aldosterone-producing adenomas (APA), the primary regulation of aldosterone production is ACTH, and there is increased production of the 18-oxygenated cortisol compounds, 18-oxocortisol and 18- hydroxycortisol. Because of these hormonal similarities, we tested whether a chimeric GRA-like gene was present in APA from 11 patients. A GRA-like chimeric gene was not found in the DNA from these tumors and, therefore, is not the mechanism responsible for hyperaldosteronism in APA.


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