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Journal of Clinical Endocrinology & Metabolism, Vol 81, 3909-3913, Copyright © 1996 by Endocrine Society

ARTICLES

Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates

RE Ostlund Jr, JW Yang, S Klein and R Gingerich
Metabolism Division, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

We measured plasma leptin concentrations by RIA in 204 normal weight and obese subjects, aged 18-80 yr, using full-length recombinant human leptin as a standard. Fasting levels between 1.2-97.9 ng/mL were observed. The plasma leptin concentration was highly correlated with percent body fat (r = 0.710; P < 0.0001) and was 3 times as high in women as in men (17.1 vs. 5.8 ng/mL; P < 0.0001). Circulating leptin was inversely related to age and was reduced 53% in subjects over age 60 yr. A statistical model containing percent body fat, gender, and age accounted for 65% of the variance in plasma leptin levels. Leptin was not independently related to abdominal fat distribution, plasma lipids and lipoproteins, chronic energy intake, diet composition, plasma insulin, or maximum oxygen consumption. However, plasma leptin was reduced by 26% in 5 obese subjects who consumed a 1000-Cal diet for 10 days (P = 0.004). We conclude that circulating leptin rises continuously with increasing adiposity. Gender, age, and short term caloric restriction may be important secondary regulators of plasma leptin.


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Am J Physiol Endocrinol Metab, February 1, 1998; 274(2): E280 - E286.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
C. Meyer, D. Robson, N. Rackovsky, V. Nadkarni, and J. Gerich
Role of the kidney in human leptin metabolism
Am J Physiol Endocrinol Metab, November 1, 1997; 273(5): E903 - E907.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
J. M. H. Elbers, H. Asscheman, J. C. Seidell, M. Frolich, A. E. Meinders, and L. J. G. Gooren
Reversal of the Sex Difference in Serum Leptin Levels upon Cross-Sex Hormone Administration in Transsexuals
J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3267 - 3270.
[Abstract] [Full Text] [PDF]

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S. Nader, M. G. Riad-Gabriel, and M. F. Saad
The Effect of a Desogestrel-Containing Oral Contraceptive on Glucose Tolerance and Leptin Concentrations in Hyperandrogenic Women
J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3074 - 3077.
[Abstract] [Full Text] [PDF]

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M. Rosenbaum, R. L. Leibel, and J. Hirsch
Obesity
N. Engl. J. Med., August 7, 1997; 337(6): 396 - 407.
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 J. Clin. Endocrinol. Metab.Home page
T. R. Nagy, B. A. Gower, C. A. Trowbridge, C. Dezenberg, R. M. Shewchuk, and M. I. Goran
Effects of Gender, Ethnicity, Body Composition, and Fat Distribution on Serum Leptin Concentrations in Children
J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2148 - 2152.
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S. M. Haffner, H. Miettinen, P. Karhapaa, L. Mykkanen, and M. Laakso
Leptin Concentrations, Sex Hormones, and Cortisol in Nondiabetic Men
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1807 - 1809.
[Abstract] [Full Text] [PDF]


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