help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Grinspoon, S.
Right arrow Articles by Klibanski, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grinspoon, S.
Right arrow Articles by Klibanski, A.

Journal of Clinical Endocrinology & Metabolism, Vol 81, 3861-3863, Copyright © 1996 by Endocrine Society

ARTICLES

Serum leptin levels in women with anorexia nervosa

S Grinspoon, T Gulick, H Askari, M Landt, K Lee, E Anderson, Z Ma, L Vignati, R Bowsher, D Herzog and A Klibanski
Massachusetts General Hospital, Boston 02114, USA.

Leptin is a protein encoded by the ob gene that is expressed in adipocytes and regulates eating behavior via central neuroendocrine mechanisms. Serum leptin levels have been shown to correlate with weight and percent body fat in normal and obese individuals; however, it is not known whether the regulation of leptin is normal below a critical threshold of body fat in chronic undernutrition. We investigated serum leptin levels in 22 women, aged 23 +/- 4 yr, with anorexia nervosa. Duration of disease, weight, BMI, percent body fat, and serum leptin levels were determined for each patient. Nutritional status was assessed further by caloric intake and measurement of insulin and insulin-like growth factor I (IGF-I) levels. Twenty-three healthy women, aged 23 +/- 4 yr, taking no medications, with normal menstrual function and body mass index (BMI) between 20-26 kg/m2 (mean, 23.7 +/- 1.7 kg/m2), served as a control population for comparison of leptin levels. Subjects with anorexia nervosa were low weight (BMI, 16.3 +/- 1.6 kg/m2; normal, 20-26 kg/m2) and exhibited a striking reduction in percent body fat (7 +/- 2%; normal, 20-30%). The mean serum leptin level was significantly decreased in subjects with anorexia nervosa compared with that in age- and sex-matched controls of normal body weight (5.6 +/- 3.7 vs. 19.1 +/- 8.1 ng/mL; P < 0.0001). Serum leptin levels were correlated highly with weight, as expressed either BMI (r = 0.66; P = 0.002) or percent ideal body weight (r = 0.68; P = 0.0005), body fat (r = 0.70; P = 0.0003), and IGF-I (r = 0.64; P = 0.001), but not with caloric intake or serum levels of estradiol or insulin in subjects with anorexia nervosa. The correlation between leptin and body fat was linear, with progressively lower, but detectable, leptin levels measured even in patients with less than 5% body fat, but was not significant when the effects of weight were taken into account. In contrast, the correlation between leptin and IGF-I remained significant when the effects of weight, body fat, and caloric intake were taken into account. In normal controls, leptin correlated with BMI (r = 0.55; P = 0.007) and IGF-I (r = 0.44; P < 0.05), but not with fat mass. These data demonstrate that serum leptin levels are reduced in association with low weight and percent body fat in subjects with anorexia nervosa compared to normal controls. Leptin levels correlate highly with weight, percent body fat, and IGF-I in subjects with anorexia nervosa, suggesting that the physiological regulation of leptin is maintained in relation to nutritional status even at an extreme of low weight and body fat.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
L. A. Kosmiski, P. Bacchetti, D. P. Kotler, S. B. Heymsfield, C. E. Lewis, M. G. Shlipak, R. Scherzer, and C. Grunfeld
Relationship of Fat Distribution with Adipokines in Human Immunodeficiency Virus Infection
J. Clin. Endocrinol. Metab., January 1, 2008; 93(1): 216 - 224.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
N. Germain, B. Galusca, C. W Le Roux, C. Bossu, M. A Ghatei, F. Lang, S. R Bloom, and B. Estour
Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY, glucagon-like peptide 1, ghrelin, and leptin
Am. J. Clinical Nutrition, April 1, 2007; 85(4): 967 - 971.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Kok, F. Roelfsema, M. Frolich, A. E. Meinders, and H. Pijl
Spontaneous Diurnal Thyrotropin Secretion Is Enhanced in Proportion to Circulating Leptin in Obese Premenopausal Women
J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6185 - 6191.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. Canavan, R. O. Salem, S. Schurgin, P. Koutkia, I. Lipinska, M. Laposata, and S. Grinspoon
Effects of Physiological Leptin Administration on Markers of Inflammation, Platelet Activation, and Platelet Aggregation during Caloric Deprivation
J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5779 - 5785.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Misra, K. K. Miller, K. Kuo, K. Griffin, V. Stewart, E. Hunter, D. B. Herzog, and A. Klibanski
Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents
Am J Physiol Endocrinol Metab, September 1, 2005; 289(3): E373 - E381.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Misra, K. K. Miller, K. Kuo, K. Griffin, V. Stewart, E. Hunter, D. B. Herzog, and A. Klibanski
Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents
Am J Physiol Endocrinol Metab, August 1, 2005; 289(2): E347 - E356.
[Abstract] [Full Text] [PDF]

Home page
 Psychosom. Med.Home page
D. Yasuhara, T. Naruo, N. Nagai, T. Muranaga, T. Nakahara, M. Tanaka, S. Kojima, K.-i. Sagiyama, A. Masuda, and A. Inui
Glucose Tolerance Predicts Short-term Refeeding Outcome in Females With Anorexia Nervosa
Psychosom Med, July 1, 2005; 67(4): 669 - 676.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. Franchimont, S. Roland, T. Gustot, E. Quertinmont, Y. Toubouti, M.-C. Gervy, J. Deviere, and A. Van Gossum
Impact of Infliximab on Serum Leptin Levels in Patients with Crohn's Disease
J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3510 - 3516.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
V. Haas, S. Onur, T. Paul, D. O Nutzinger, A. Bosy-Westphal, M. Hauer, G. Brabant, H. Klein, and M. J Muller
Leptin and body weight regulation in patients with anorexia nervosa before and during weight recovery
Am. J. Clinical Nutrition, April 1, 2005; 81(4): 889 - 896.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Schurgin, B. Canavan, P. Koutkia, A. M. DePaoli, and S. Grinspoon
Endocrine and Metabolic Effects of Physiologic r-metHuLeptin Administration during Acute Caloric Deprivation in Normal-Weight Women
J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5402 - 5409.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Bluher and C. S. Mantzoros
The Role of Leptin in Regulating Neuroendocrine Function in Humans
J. Nutr., September 1, 2004; 134(9): 2469S - 2474S.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Misra, K. K. Miller, C. Almazan, K. Ramaswamy, A. Aggarwal, D. B. Herzog, G. Neubauer, J. Breu, and A. Klibanski
Hormonal and Body Composition Predictors of Soluble Leptin Receptor, Leptin, and Free Leptin Index in Adolescent Girls with Anorexia Nervosa and Controls and Relation to Insulin Sensitivity
J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3486 - 3495.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Tagami, N. Satoh, T. Usui, K. Yamada, A. Shimatsu, and H. Kuzuya
Adiponectin in Anorexia Nervosa and Bulimia Nervosa
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1833 - 1837.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
V. Popovic, M. Djurovic, A. Cetkovic, D. Vojvodic, S. Pekic, S. Spremovic, M. Petakov, S. Damjanovic, N. Milic, C. Dieguez, et al.
Inhibin B: A Potential Marker of Gonadal Activity in Patients with Anorexia Nervosa during Weight Recovery
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1838 - 1843.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Pannacciulli, R. Vettor, G. Milan, M. Granzotto, A. Catucci, G. Federspil, P. De Giacomo, R. Giorgino, and G. De Pergola
Anorexia Nervosa Is Characterized by Increased Adiponectin Plasma Levels and Reduced Nonoxidative Glucose Metabolism
J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1748 - 1752.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
V. Tolle, M. Kadem, M.-T. Bluet-Pajot, D. Frere, C. Foulon, C. Bossu, R. Dardennes, C. Mounier, P. Zizzari, F. Lang, et al.
Balance in Ghrelin and Leptin Plasma Levels in Anorexia Nervosa Patients and Constitutionally Thin Women
J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 109 - 116.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Ozata, C. Dieguez, and F. F. Casanueva
The Inhibition of Growth Hormone Secretion Presented in Obesity Is Not Mediated by the High Leptin Levels: A Study in Human Leptin Deficiency Patients
J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 312 - 316.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
E. S. Rome, S. Ammerman, D. S. Rosen, R. J. Keller, J. Lock, K. A. Mammel, J. O'Toole, J. M. Rees, M. J. Sanders, S. M. Sawyer, et al.
Children and Adolescents With Eating Disorders: The State of the Art
Pediatrics, January 1, 2003; 111(1): e98 - 108.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Palacio, M. Lopez, F. Perez-Bravo, F. Monkeberg, and L. Schlesinger
Leptin Levels Are Associated with Immune Response in Malnourished Infants
J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3040 - 3046.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. van Crevel, E. Karyadi, M. G. Netea, H. Verhoef, R. H. H. Nelwan, C. E. West, and J. W. M. van der Meer
Decreased Plasma Leptin Concentrations in Tuberculosis Patients Are Associated with Wasting and Inflammation
J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 758 - 763.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Coutant, F. Boux de Casson, S. Rouleau, O. Douay, E. Mathieu, M. Audran, and J. M. Limal
Body Composition, Fasting Leptin, and Sex Steroid Administration Determine GH Sensitivity in Peripubertal Short Children
J. Clin. Endocrinol. Metab., December 1, 2001; 86(12): 5805 - 5812.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
N. Boissel, B. Wechsler, and V. Leblond
Treatment of Refractory Erdheim-Chester Disease with Double Autologous Hematopoietic Stem-Cell Transplantation
Ann Intern Med, November 6, 2001; 135(9): 844 - 845.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Coutant, F. Boux de Casson, O. Douay, E. Mathieu, S. Rouleau, F. Beringue, P. Gillard, J. M. Limal, and P. Descamps
Relationships between Placental GH Concentration and Maternal Smoking, Newborn Gender, and Maternal Leptin: Possible Implications for Birth Weight
J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4854 - 4859.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Ghizzoni, G. Mastorakos, M. E. Street, G. Mazzardo, A. Vottero, M. Vanelli, and S. Bernasconi
Leptin, Cortisol, and GH Secretion Interactions in Short Normal Prepubertal Children
J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3729 - 3734.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Ghizzoni, G. Mastorakos, M. Ziveri, M. Furlini, A. Solazzi, A. Vottero, and S. Bernasconi
Interactions of Leptin and Thyrotropin 24-Hour Secretory Profiles in Short Normal Children
J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 2065 - 2072.
[Abstract] [Full Text]

Home page
 JNCI J Natl Cancer InstHome page
R. Kaaks, S. Soderberg, T. Olsson, G. Hallmans, and P. Stattin
RESPONSE: Re: Plasma Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk: a Prospective Study
J Natl Cancer Inst, April 18, 2001; 93(8): 650 - 651.
[Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
L Bowles and P Kopelman
Leptin: of mice and men?
J. Clin. Pathol., January 1, 2001; 54(1): 1 - 3.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. C. Jimerson, C. Mantzoros, B. E. Wolfe, and E. D. Metzger
Decreased Serum Leptin in Bulimia Nervosa
J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4511 - 4514.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Monteleone, F. Bortolotti, M. Fabrazzo, A. La Rocca, A. Fuschino, and M. Maj
Plasma Leptin Response to Acute Fasting and Refeeding in Untreated Women with Bulimia Nervosa
J. Clin. Endocrinol. Metab., July 1, 2000; 85(7): 2499 - 2503.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
M. Rozhavskaya-Arena, D. W. Lee, M. C. Leinung, and P. Grasso
Design of a Synthetic Leptin Agonist: Effects on Energy Balance, Glucose Homeostasis, and Thermoregulation
Endocrinology, July 1, 2000; 141(7): 2501 - 2507.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A. Polito, A. Fabbri, A. Ferro-Luzzi, M. Cuzzolaro, L. Censi, D. Ciarapica, E. Fabbrini, and D. Giannini
Basal metabolic rate in anorexia nervosa: relation to body composition and leptin concentrations
Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1495 - 1502.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Uckaya, M. Ozata, A. Sonmez, C. Kinalp, T. Eyileten, N. Bingol, B. Koc, F. Kocabalkan, and I. C. Ozdemir
Is Leptin Associated with Hypertensive Retinopathy?
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 683 - 687.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. S. Damjanovic, M. S. Petakov, D. Micic, J. Marinkovic, C. Dieguez, F. F. Casanueva, and V. Popovic
Serum Leptin Levels in Patients with Acromegaly before and after Correction of Hypersomatotropism by Trans-Sphenoidal Surgery
J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 147 - 154.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Ozata, I. C. Ozdemir, and J. Licinio
Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated Defects
J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3686 - 3695.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Jin, B. G. Burguera, M. E. Couce, B. W. Scheithauer, J. Lamsan, N. L. Eberhardt, E. Kulig, and R. V. Lloyd
Leptin and Leptin Receptor Expression in Normal and Neoplastic Human Pituitary: Evidence of a Regulatory Role for Leptin on Pituitary Cell Proliferation
J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2903 - 2911.
[Abstract] [Full Text]

Home page
 ANN INTERN MEDHome page
C. S. Mantzoros
The Role of Leptin in Human Obesity and Disease: A Review of Current Evidence
Ann Intern Med, April 20, 1999; 130(8): 671 - 680.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. E. Becker, S. K. Grinspoon, A. Klibanski, and D. B. Herzog
Eating Disorders
N. Engl. J. Med., April 8, 1999; 340(14): 1092 - 1098.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. TAKABATAKE, H. NAKAMURA, S. ABE, T. HINO, H. SAITO, H. YUKI, S. KATO, and H. TOMOIKE
Circulating Leptin in Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): 1215 - 1219.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. P. Warren, F. Voussoughian, E. B. Geer, E. P. Hyle, C. L. Adberg, and R. H. Ramos
Functional Hypothalamic Amenorrhea: Hypoleptinemia and Disordered Eating
J. Clin. Endocrinol. Metab., March 1, 1999; 84(3): 873 - 877.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
S. P. Kalra, M. G. Dube, S. Pu, B. Xu, T. L. Horvath, and P. S. Kalra
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Endocr. Rev., February 1, 1999; 20(1): 68 - 100.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Van den Berghe, P. Wouters, L. Carlsson, R. C. Baxter, R. Bouillon, and C. Y. Bowers
Leptin Levels in Protracted Critical Illness: Effects of Growth Hormone-Secretagogues and Thyrotropin-Releasing Hormone
J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3062 - 3070.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. R. Palmert, S. Radovick, and P. A. Boepple
Leptin Levels in Children with Central Precocious Puberty
J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2260 - 2265.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. K. Miller, M. S. Parulekar, E. Schoenfeld, E. Anderson, J. Hubbard, A. Klibanski, and S. K. Grinspoon
Decreased Leptin Levels in Normal Weight Women with Hypothalamic Amenorrhea: The Effects of Body Composition and Nutritional Intake
J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2309 - 2312.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Leal-Cerro, P. P. Garcia-Luna, R. Astorga, J. Parejo, R. Peino, C. Dieguez, and F. F. Casanueva
Serum Leptin Levels in Male Marathon Athletes before and after the Marathon Run
J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2376 - 2379.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. A. Llopis, M. L. Granada, G. Cuatrecasas, X. Formiguera, L. Sánchez-Planell, A. SanmartÍ, A. Alastrué, M. Rull, A. Corominas, and M. Foz
Growth Hormone-Binding Protein Directly Depends on Serum Leptin Levels in Adults with Different Nutritional Status
J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 2006 - 2011.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
X. Casabiell, V. Piñeiro, R. Peino, M. Lage, J. Camiña, R. Gallego, L. G. Vallejo, C. Dieguez, and F. F. Casanueva
Gender Differences in Both Spontaneous and Stimulated Leptin Secretion by Human Omental Adipose Tissue in Vitro: Dexamethasone and Estradiol Stimulate Leptin Release in Women, But Not in Men
J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 2149 - 2155.
[Abstract] [Full Text]

Home page
 J. Am. Coll. Nutr.Home page
C. S. Mantzoros, A. S. Prasad, F. W.J. Beck, S. Grabowski, J. Kaplan, C. Adair, and G. J. Brewer
Zinc May Regulate Serum Leptin Concentrations in Humans
J. Am. Coll. Nutr., June 1, 1998; 17(3): 270 - 275.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
B. T. Walsh and M. J. Devlin
Eating Disorders: Progress and Problems
Science, May 29, 1998; 280(5368): 1387 - 1390.
[Abstract] [Full Text]

Home page
 J. Lipid Res.Home page
S. Ranganathan, M. Maffei, and P. A. Kern
Adipose tissue ob mRNA expression in humans: discordance with plasma leptin and relationship with adipose TNF{alpha} expression
J. Lipid Res., April 1, 1998; 39(4): 724 - 730.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. R. Palmert, S. Radovick, and P. A. Boepple
The Impact of Reversible Gonadal Sex Steroid Suppression on Serum Leptin Concentrations in Children with Central Precocious Puberty
J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1091 - 1096.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. D. Eckert, C. Pomeroy, N. Raymond, P. F. Kohler, P. Thuras, and C. Y. Bowers
Leptin in Anorexia Nervosa
J. Clin. Endocrinol. Metab., March 1, 1998; 83(3): 791 - 795.
[Abstract] [Full Text]

Home page
 Clin. Chem.Home page
M. Landt, R. L. Gingerich, P. J. Havel, W. M. Mueller, B. Schoner, J. E. Hale, and M. L. Heiman
Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans
Clin. Chem., March 1, 1998; 44(3): 565 - 570.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
V. C. Pardini, I. M. N. Victória, S. M. V. Rocha, D. G. Andrade, A. M. Rocha, F. B. Pieroni, G. Milagres, S. Purisch, and G. Velho
Leptin Levels, {beta}-Cell Function, and Insulin Sensitivity in Families with Congenital and Acquired Generalized Lipoatropic Diabetes
J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 503 - 508.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. A. Laughlin, C. E. Dominguez, and S. S. C. Yen
Nutritional and Endocrine-Metabolic Aberrations in Women with Functional Hypothalamic Amenorrhea
J. Clin. Endocrinol. Metab., January 1, 1998; 83(1): 25 - 32.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Dagogo-Jack, G. Selke, A. K. Melson, and J. W. Newcomer
Robust Leptin Secretory Responses to Dexamethasone in Obese Subjects
J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3230 - 3233.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
V. Matkovic, J. Z. Ilich, M. Skugor, N. E. Badenhop, P. Goel, A. Clairmont, D. Klisovic, R. W. Nahhas, and J. D. Landoll
Leptin Is Inversely Related to Age at Menarche in Human Females
J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3239 - 3245.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. V. Garcia-Mayor, M. A. Andrade, M. Rios, M. Lage, C. Dieguez, and F. F. Casanueva
Serum Leptin Levels in Normal Children: Relationship to Age, Gender, Body Mass Index, Pituitary-Gonadal Hormones, and Pubertal Stage
J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 2849 - 2855.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Mantzoros, J. S. Flier, M. D. Lesem, T. D. Brewerton, and D. C. Jimerson
Cerebrospinal Fluid Leptin in Anorexia Nervosa: Correlation with Nutritional Status and Potential Role in Resistance to Weight Gain
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1845 - 1851.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1996 by The Endocrine Society