| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 81, 222-227, Copyright © 1996 by Endocrine Society
ARTICLES |
JM Dubuis, J Glorieux, F Richer, CL Deal, JH Dussault and G Van Vliet
Research Unit on the Biology of Reproduction and Development, Sainte- Justine Hospital, Montreal, Quebec, Canada.
We have previously reported that despite neonatal screening, children with severe congenital hypothyroidism treated at 5 weeks of age with 6 micrograms/kg.day levothyroxine have clinically significant intellectual impairment, whereas those with the moderate form of the disease are indistinguishable from controls. The developmental outcome of children with severe congenital hypothyroidism treated earlier with higher initial doses of levothyroxine remained to be determined. In the present study, 45 infants with permanent congenital hypothyroidism detected by neonatal screening are described. For the group, the median age at starting treatment was 14 days, and the median initial dose of levothyroxine was 11.6 micrograms/kg.day. Based on the area of their knee epiphyses at diagnosis, the patients were divided into 2 subgroups: severe (< 0.05 cm2; n = 10) and moderate (> or = 0.05 cm2; n = 35). The psychomotor development of 8 patients in each subgroup, matched for the socioeducational level of their families, was assessed at 18 months. Mean plasma free T4 levels were supraphysiological during the first few months of life, but mean plasma T3 levels remained within the normal range, and there were no signs or symptoms of hyperthyroidism. The mean plasma TSH concentration was less than 4.5 mIU/L 4 weeks after starting treatment. Bone maturation remained delayed at 12 months in the severe cases and was not unduly advanced in the moderate cases. The mean (+/- SD) developmental quotients at 18 months were similar in severe and moderate cases (107 +/- 10 and 110 +/- 5, respectively). We conclude that with earlier treatment and a higher initial dose of levothyroxine, the early developmental outcome of infants with severe congenital hypothyroidism is now indistinguishable from that of infants with the moderate form of the disease who were used as controls.
This article has been cited by other articles:
 |
|
 |
|
  M Korada, M S Pearce, M P Ward Platt, E Avis, S Turner, H Wastell, and T Cheetham Repeat testing for congenital hypothyroidism in preterm infants is unnecessary with an appropriate thyroid stimulating hormone threshold Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2008; 93(4): F286 - F288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Korada, M Kibirige, S Turner, J Day, H Johnstone, and T Cheetham The implementation of revised guidelines and the performance of a screening programme for congenital hypothyroidism J Med Screen, March 1, 2008; 15(1): 5 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. E. Kempers, L. van der Sluijs Veer, R. W. G. Nijhuis-van der Sanden, C. I. Lanting, L. Kooistra, B. M. Wiedijk, B. F. Last, J. J. M. de Vijlder, M. A. Grootenhuis, and T. Vulsma Neonatal Screening for Congenital Hypothyroidism in The Netherlands: Cognitive and Motor Outcome at 10 Years of Age J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 919 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nakamizo, S.-i. Toyabe, T. Asami, and K. Akazawa Mental Development of Infants With Congenital Hypothyroidism: A Longitudinal Study Clinical Pediatrics, January 1, 2007; 46(1): 53 - 58. [Abstract] [PDF]
|
|
|
|
 |
|
 C. I. Kaye and and the Committee on Genetics Newborn Screening Fact Sheets Pediatrics, September 1, 2006; 118(3): e934 - e963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Farwell, S. A. Dubord-Tomasetti, A. Z. Pietrzykowski, and J. L. Leonard Dynamic Nongenomic Actions of Thyroid Hormone in the Developing Rat Brain Endocrinology, May 1, 2006; 147(5): 2567 - 2574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. E. Kempers, L. van der Sluijs Veer, M. W. G. Nijhuis-van der Sanden, L. Kooistra, B. M. Wiedijk, I. Faber, B. F. Last, J. J. M. de Vijlder, M. A. Grootenhuis, and T. Vulsma Intellectual and Motor Development of Young Adults with Congenital Hypothyroidism Diagnosed by Neonatal Screening J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 418 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Eugene, A. Djemli, and G. Van Vliet Sexual Dimorphism of Thyroid Function in Newborns with Congenital Hypothyroidism J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2696 - 2700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S M Park and V K K Chatterjee Genetics of congenital hypothyroidism J. Med. Genet., May 1, 2005; 42(5): 379 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J H Lazarus Congenital hypothyroidism Arch. Dis. Child., February 1, 2005; 90(2): 112 - 113. [Full Text] [PDF]
|
|
|
|
|
|
B Oerbeck, K Sundet, B F Kase, and S Heyerdahl Congenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour Arch. Dis. Child., February 1, 2005; 90(2): 132 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Rovet Children With Congenital Hypothyroidism and Their Siblings: Do They Really Differ? Pediatrics, January 1, 2005; 115(1): e52 - e57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S C Conrad, H Chiu, and B L Silverman Soy formula complicates management of congenital hypothyroidism Arch. Dis. Child., January 1, 2004; 89(1): 37 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Oerbeck, K. Sundet, B. F. Kase, and S. Heyerdahl Congenital Hypothyroidism: Influence of Disease Severity and L-Thyroxine Treatment on Intellectual, Motor, and School-Associated Outcomes in Young Adults Pediatrics, October 1, 2003; 112(4): 923 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Van Vliet, B. Larroque, L. Bubuteishvili, K. Supernant, and J. Leger Sex-Specific Impact of Congenital Hypothyroidism due to Thyroid Dysgenesis on Skeletal Maturation in Term Newborns J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 2009 - 2013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Perry, C. Heinrichs, P. Bourdoux, K. Khoury, F. Szots, J. H. Dussault, G. Vassart, and G. Van Vliet Discordance of Monozygotic Twins for Thyroid Dysgenesis: Implications for Screening and for Molecular Pathophysiology J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4072 - 4077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. van Wassenaer, J. M. Briet, A. van Baar, B. J. Smit, P. Tamminga, J. J. M. de Vijlder, and J. H. Kok Free Thyroxine Levels During the First Weeks of Life and Neurodevelopmental Outcome Until the Age of 5 Years in Very Preterm Infants Pediatrics, September 1, 2002; 110(3): 534 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Hrytsiuk, R. Gilbert, S. Logan, S. Pindoria, and C. G. D. Brook Starting Dose of Levothyroxine for the Treatment of Congenital Hypothyroidism: A Systematic Review Arch Pediatr Adolesc Med, May 1, 2002; 156(5): 485 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hanukoglu, K. Perlman, I. Shamis, L. Brnjac, J. Rovet, and D. Daneman Relationship of Etiology to Treatment in Congenital Hypothyroidism J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 186 - 191. [Abstract] [Full Text]
|
|
|
|
|
|
J. F. Rovet and R. Ehrlich Psychoeducational Outcome in Children With Early-Treated Congenital Hypothyroidism Pediatrics, March 1, 2000; 105(3): 515 - 522. [Abstract] [Full Text]
|
|
|
|
|
|
The Anecdotal History of Screening for Congenital Hypothyroidism J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4332 - 4334. [Full Text]
|
|
|
|
|
|
H. Devos, C. Rodd, N. Gagné, R. Laframboise, and G. Van Vliet A Search for the Possible Molecular Mechanisms of Thyroid Dysgenesis: Sex Ratios and Associated Malformations J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2502 - 2506. [Abstract] [Full Text]
|
|
|
|
|
|
N. Gagné, J. Parma, C. Deal, G. Vassart, and G. Van Vliet Apparent Congenital Athyreosis Contrasting with Normal Plasma Thyroglobulin Levels and Associated with Inactivating Mutations in the Thyrotropin Receptor Gene: Are Athyreosis and Ectopic Thyroid Distinct Entities? J. Clin. Endocrinol. Metab., May 1, 1998; 83(5): 1771 - 1775. [Abstract] [Full Text]
|
|
|
|
|
|
J Raza, P C Hindmarsh, and C G D Brook Factors involved in the rate of fall of thyroid stimulating hormone in treated hypothyroidism Arch. Dis. Child., December 1, 1997; 77(6): 526 - 527. [Abstract] [Full Text]
|
|
|
|
|
|
N. Momotani, J. Yoshimura Noh, N. Ishikawa, and K. Ito Effects of Propylthiouracil and Methimazole on Fetal Thyroid Status in Mothers with Graves' Hyperthyroidism J. Clin. Endocrinol. Metab., November 1, 1997; 82(11): 3633 - 3636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Vogiatzi and J. L. Kirkland Frequency and Necessity of Thyroid Function Tests in Neonates and Infants With Congenital Hypothyroidism Pediatrics, September 1, 1997; 100(3): e6 - e6. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
